Evaluation of the antimalarial activity of aqueous leaf extracts of &lt;i&gt;Casuarina equistifolia&lt;/i&gt; and &lt;i&gt;Mangifera indica&lt;/i&gt; against &lt;i&gt;Plasmodium berghei&lt;/i&gt; in mice

Malann, YD; Bm, Matur; Mailafia, S

doi:10.4314/jpb.v10i1.2

Cited by 3 publications

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“…The preliminary photochemical screening and the acute toxicity study on C. equistifolia and M. indica extracts indicated the relative safety level of the plants extracts as well as the presence of the following metabolites; tannins, flavonoids, cardiac glycosides, steroids and carbohydrates. (Malann and Ajayi, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…We employed these plants to evaluate their antimalarial properties as justification of their usefulness in traditional medicine. The preliminary reports on the aqueous extracts indicated activity against P. berghei in laboratory mice in all the three test models; suppressive, curative (established) or repository (Malann and Ajayi, 2008).…”

Section: Mangifera Indica (Anacardacecae) Andmentioning

confidence: 99%

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Effects of Mangifera indica and Casuarina equistifolia extracts on survival and haematocrit of Plasmodium berghei infected mice

Malann¹,

Ajayi²

2012

J. Pharm Bio.

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The mean survival time (mst) and haematocrit was determined following treatment of Plasmodium berghei infected mice with Casuarina equistifolia and Mangifera indica (leaf) extracts during established infection and repository test procedures. The survival time was significant (P<0.05) and dose dependent compared to the control group. The packed cell volume (PCV) taken on day zero and seven following established infection indicated that both extracts failed significantly (P<0.0.5) in preventing reduction of PCV in infected mice although some what lesser percentages where observed in 400 and 200mg/kg C. equistifolia. In the repository test, significant drop in PCV (P<0.05) was observed in all the groups except the chloroquine phosphate group.

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Section: Discussionmentioning

confidence: 99%

Section: Mangifera Indica (Anacardacecae) Andmentioning

confidence: 99%

Effects of Mangifera indica and Casuarina equistifolia extracts on survival and haematocrit of Plasmodium berghei infected mice

Malann¹,

Ajayi²

2012

J. Pharm Bio.

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“…Aside its local use for the treatment of typhoid fever, Mangifera indica is also used for the treatment of malaria (bark and fruits) (22), as food (fruit), as remedy for exhaustion and heat stroke (unripe fruit juice), blood disorders, gastrointestinal disorders, scurvy, night blindness caused by Vitamin A deficiency (ripe fruit), diabetes (leaves), and diarrhoea (seed). Mango plant has been shown to possess antimalarial (23) as well as antibacterial activities, including activities against Staphylococcus aureus, Streptococcus pneumoniae, Proteus mirabilis and Salmonella typhi (24), and antidiabetic activities (25). Hence, this study will add to the body of evidence of the anti-salmonellal activities of M. indica using aqueous and ethanolic extracts of its stem bark.…”

Section: Introductionmentioning

confidence: 96%

Evaluation of Anti-Salmonellal Activities of the Aqueous andEthanolic Extracts of Selected Nigerian Medicinal Plants used Locally for Typhoid Fever Treatment

Usman,

Okoro,

Oreagba

et al. 2018

JBMS

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Background: Many Nigerian medicinal plants are used locally for the treatment of typhoid fever by traditional medicine practitioners and herb sellers. However, the laboratory evaluation of the efficacy and anti-salmonellal activities of such plants are sparse. Objective: The objective of this study was to evaluate the anti-salmonellal activities of six Nigerian medicinal plants that are used locally for the treatment of typhoid fever. Method: The ethanolic and aqueous extracts of six medicinal plants, viz. Ficus exasperata, Lannea egregia, Lophira alata, Mangifera indica, Momordica charantia and Morinda lucida were screened for in-vitro activities against Salmonella typhi. Kirby-bauer disc diffusion method was used to determine the inhibitory property of the extracts at concentrations of 12.5, 25, 50 and 100 mg/ml. The plants were also screened for phytochemical components using standard methods. Results: All the plant extracts, except the aqueous extracts of Lophira alata, Morinda lucida and ethanolic extract of Momordica charantia, exhibited significant anti-salmonellal activities at concentration of 100 mg/ml with the aqueous extract of Mangifera indica showing the highest anti-salmonellal activity producing zone of inhibition of 16.67±0.67 mm followed by ethanolic extracts of Morinda lucida (12.67±1.20 mm), Lannea egregia (11.33±0.33 mm), Ficus exasperata (11.00±0.00 mm), Lophira alata (10.33±0.33 mm) and Momordica charantia (aqueous extract) (8.33±4.26 mm). However, all the extracts were less active than amoxicillin (18.67±0.67 mm) and ciprofloxacin (38.67±0.33 mm). Conclusion: Mangifera indica, Morinda lucida, Momordica charantia, Lannea egregia, Lophira alata and Ficus exasperata possess anti-salmonellal activities. This justifies their traditional use for the treatment of typhoid fever and their active constituents may serve as leads in the production of new anti-typhoid drugs.

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“…This assertion was corroborated byBidla et al (2004), they confirm the action of M. indica extracts on Plasmodium falciparum. In like manner,Malann et al (2013) gave insight into the effectiveness of the leaf extract on P. berghei, while inhibition of HSV-1 and HSV-2 herpes simplex virus replication was communicated byZhu et al (1993) andZheng and Lu (1990). The stage reliant action of M. indica aqueous extract on animal nematode Trichinella spiralis was accentuated by Garcia et al (2003) while, Gehad et al (2013) reported the 100% multiplication inhibition of Strongyloides stercoralis larvae with aqueous extract of unripe M. indica fruit.…”

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confidence: 98%

Fractions from Mangifera indica as an Alternative in Meloidogyne incognita Management

Fabiyi¹

2022

PJN

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Pesticide residues and metabolites are often found in fruits, vegetables, soil and underground water as contaminants. This necessitated the search for bio-nematicides, accordingly the nematicidal prospect of chromatographic fractions from Mangifera indica as a substitute to synthetic nematicides in the control of Meloidogyne incognita pests of tomato was evaluated. Crude extracts of M. indica bark was fractionated on silica-gel (120-150 mesh) using glass column. The resulting fractions were investigated in screenhouse and field trials. The fractions were equated with carbofuran a synthetic nematicide. Each experimental pot containing 40 kg of pasteurized soil was inoculated with 1000 eggs of M. incognita in the screenhouse, while 2500 eggs was introduced to the base of each tomato plant on the field. Significant (p<0.05) increase was noted in the vegetative growth of treated tomato plants. Fruit weight per plant and number of fruits per plant increased notably as opposed to the untreated tomato plants. Nematode population in root and soil of treated tomato plants also reduced significantly. Terpenes, esters, aldehydes, phenols and ketones were identified as the major constituents of the fractions with partial characterization. The reduction in nematode population in the screenhouse and field signifies that fractions from M. indica could be employed in place of the environmentally undependable synthetic nematicides, while encouraging a sustainable and safe environment in tomato cultivation.

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Evaluation of the antimalarial activity of aqueous leaf extracts of <i>Casuarina equistifolia</i> and <i>Mangifera indica</i> against <i>Plasmodium berghei</i> in mice

Cited by 3 publications

References 0 publications

Effects of <em>Mangifera indica</em> and Casuarina equistifolia extracts on survival and haematocrit of <em>Plasmodium berghei</em> infected mice

Effects of <em>Mangifera indica</em> and Casuarina equistifolia extracts on survival and haematocrit of <em>Plasmodium berghei</em> infected mice

Evaluation of Anti-Salmonellal Activities of the Aqueous andEthanolic Extracts of Selected Nigerian Medicinal Plants used Locally for Typhoid Fever Treatment

Fractions from Mangifera indica as an Alternative in Meloidogyne incognita Management

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