Evaluation of the antihepatotoxic activity of the biflavonoids of Garcinia kola seed

Iwu, Maurice M.; Igboko, Ogo A.; Onwuchekwa, Uloma A.; Okunji, Christopher O.

doi:10.1016/0378-8741(87)90123-1

Cited by 98 publications

(71 citation statements)

References 6 publications

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“…Guttiferae) have shown antiviral and anti-inflammatory properties. 57 A herbal formulation of bitter-kola (G. kola) and the leaves of Kinkeliba (Combretum micranthum) enjoys a folk reputation as an effective treatment for the management of liver diseases of unknown etiology. Extracts of Combretum have been shown to prevent chemical-induced damage to the liver and to exhibit in vitro antiviral activity.…”

Section: Blended Herbal Formulations and Extractsmentioning

confidence: 99%

Complementary and alternative medicine in chronic liver disease

et al. 2001

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Section: Blended Herbal Formulations and Extractsmentioning

confidence: 99%

Complementary and alternative medicine in chronic liver disease

et al. 2001

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“…Studies have also reported the use of this plant for the treatment of jaundice, high fever, purgative and as chewing stick. The plant also found usefulness in the treatment of stomach ache and gastritis [5,6]. The phytochemical compounds isolated from G. kola include oleoresin, tannins, saponins, alkaloids, cardiac glycosides.…”

Section: Introductionmentioning

confidence: 99%

“…Garcinia kola is also used in folklore remedies for the treatment of various infections caused by pathogens [7]. Kolaviron (KV) (Figure 1), the predominant constituent in G. kola, contains biflavanones (GB1, GB2 and kolaflavanone) and has been reported to prevent hepatotoxicity mediated by several toxins [6,8,9]. Likewise, kolaviron exhibited hypoglycemic effects in normal and alloxan-and streptozotocin-induced diabetic animals [10,11].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effects of Kolaviron, a Biflavonoid Complex of <i>Garcinia kola</i>, on Rats Hippocampus against Methamphetamine-Induced Neurotoxicity

Ijomone¹,

Nwoha²,

Olaibi³

et al. 2012

Macedonian Journal of Medical Sciences

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Aim: To investigate the protective effects of kolaviron on brain weight and behavioural performance and the histology of the hippocampus of adult Wistar rats following methamphetamine challenge. Materials and Methods:Twenty four adult Wistar rats weighing between 150-200 g, randomly assigned into four groups of six each (Groups A, B, C, D) were used for this research. Group A served as control, while groups B and C were given single dose methamphetamine (10 mg/kg) intraperitoneally after group C was pre-treated with kolaviron (200 mg/kg) for 7 days and group D received cornoil (vehicle for kolaviron) only.Results: High level of methamphetamine-induced stereotypic movement was observed, and the onset was delayed by kolaviron administration. Animals administered methamphetamine only, showed significantly poor behavioural performance on the water maze after treatment when compared to the other groups (P<0.05). Histological analysis revealed neuronal destruction of the pyramidal layer of the hippocampus following methamphetamine administration. Kolaviron to some extent prevented destruction of pyramidal cells of the hippocampus in pre-treated rats. Conclusion:The present findings show the neuro-destructive effects of methamphetamine on hippocampal neurons and its ability to negatively affect behaviour and that kolaviron could prevent such behavioural deficit and also afford some protection to the hippocampus.

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“…The biflavanones are the most dominant in most Garcinia species (Waterman and Hussain, 1983). Kolaviron (KV), the predominant constituent in Garcinia kola is a biflavonoid complex that has been reported to prevent hepatotoxicity mediated by several toxins (Iwu et al, 1987;Adaramoye and Adeyemi, 2006a). Likewise, KV is known to exhibit hypoglycemic effects in normal, alloxan and streptozotocin-diabetic animals (Iwu et al, 1990;Adaramoye and Adeyemi, 2006b).…”

Section: Introductionmentioning

confidence: 99%

Endothelium-independent vasodilation induced by kolaviron, a biflavonoid complex from Garcinia kola seeds, in rat superior mesenteric arteries

Adaramoye¹,

Medeiros²

2009

J Smooth Muscle Res

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Previous studies have established the hepatoprotective, gastroprotective, hypolipidemic and hypoglycemic effects of kolaviron (KV), a biflavonoid complex from Garcinia kola seeds. In this study, we investigated the mechanisms involved in the vasorelaxant effects of KV in isolated superior mesenteric arteries from normotensive rats. KV (1, 10, 30, 100, 300, 500 and 1,000 µg/ml) concentration-dependently inhibited the contractions induced by phenylephrine (PHE) (10 µM) and KCl (80 mM) in both endothelium-intact (Emax = 58.3 ± 1.7% and 51.4 ± 1.3%, respectively) and -denuded rings (Emax = 59.3 ± 5.5% and 64.3 ± 2.4%, respectively). Furthermore, KV reduced CaCl2-induced contraction in Ca 2+ -free medium containing KCl 60 mM, thus acting as a Ca 2+ -antagonist. In addition, KV inhibited the transient contraction by PHE in Ca 2+ -free medium containing EGTA, suggesting a possible action on the release of intracellular Ca 2+ via the inositol-1,4,5-triphosphate (IP3) pathway.KV is not a specific α-adrenoceptor blocker, since it also caused a concentration-dependent inhibition of contractile responses to KCl, suggesting that KV also blocks the L-type Ca 2+ -channel. As a Ca 2+ antagonist, KV (100 µg/ml) potentiates the relaxant effects of nifedipine in denuded rings (Emax = 97.6 ± 1.2%; control = 75.1 ± 3.0%, P<0.05). Also, the vasorelaxation induced by KV was significantly inhibited after pre-treatment of the denuded rings with 4-aminopyridine (4-AP) 1 mM, a selective blocker of voltage-dependent K + (Kv) channels and,

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Evaluation of the antihepatotoxic activity of the biflavonoids of Garcinia kola seed

Cited by 98 publications

References 6 publications

Complementary and alternative medicine in chronic liver disease

Complementary and alternative medicine in chronic liver disease

Neuroprotective Effects of Kolaviron, a Biflavonoid Complex of <i>Garcinia kola</i>, on Rats Hippocampus against Methamphetamine-Induced Neurotoxicity

Endothelium-independent vasodilation induced by kolaviron, a biflavonoid complex from Garcinia kola seeds, in rat superior mesenteric arteries

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