Evaluation of the antifungal effect of plant extracts on oral
            <i>Candida</i>
            spp. – a critical methodological analysis of the last decade

Maziere, M.; Andrade, J. C.; Rompante, P.; Rodrigues, C. F.

doi:10.1080/1040841x.2024.2326995

Critical Reviews in Microbiology

2024

DOI: 10.1080/1040841x.2024.2326995

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Evaluation of the antifungal effect of plant extracts on oral Candida spp. – a critical methodological analysis of the last decade

M. Maziere,

J. C. Andrade,

P. Rompante

et al.

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Are Mouthwashes Really Effective against Candida spp.?

Maziere,

Rompante,

Andrade

et al. 2024

JoF

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Oral candidiasis is an opportunistic infection caused by fungi of the genus Candida. Nystatin, fluconazole, and miconazole are the most widely used antifungal drugs in dentistry, but in recent years, they have been shown to be less effective due to the increase in the resistance to antifungal drugs. The growing challenge of antifungal resistance emphasizes the importance of exploring not only alternative strategies in the fight against Candida spp. infections but also supportive treatment for pharmacological treatment for oral candidiasis. This review aims to evaluate and compare the in vitro reports on antifungal efficacy against Candida spp. exhibited by mouthwashes distributed on the European market. The research question was elaborated through the PEO framework recommended by PRISMA 2020. A bibliographic search strategy was developed for the scientific online databases Pubmed and ScienceDirect. According to the eligibility criteria, 21 papers were included in this study over a 27-year period. Mouthwashes containing chlorhexidine digluconate, cetylpyridinium chloride, hexetidine, and fluorine compounds among others, and natural antimicrobials, such as menthol, thymol, eucalyptol, and Glycyrrhiza glabra extracts, have demonstrated antifungal effectiveness. Nonetheless, the methodological variance introduces ambiguity concerning the comparative efficacy of distinct molecules or mouthwash formulations and complicates the evaluation and the comparison of results between studies. Some mouthwashes commercially available in Europe have the potential to be used in anti-Candida therapy and prevention since they have shown antifungal effect.

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Are Mouthwashes Really Effective against Candida spp.?

Maziere,

Rompante,

Andrade

et al. 2024

JoF

View full text Add to dashboard Cite

show abstract

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Evaluation of the antifungal effect of plant extracts on oral Candida spp. – a critical methodological analysis of the last decade

Cited by 1 publication

References 31 publications

Are Mouthwashes Really Effective against Candida spp.?

Are Mouthwashes Really Effective against Candida spp.?

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