Evaluation of the antifungal and biochemical activities of mefentrifluconazole against Botrytis cinerea

Analysis of the fungicidal efficacy, environmental fate, and safety of the application of a mefentrifluconazole and pyraclostrobin mixture to control mango anthracnose

“…4,5 The ability of mefentrifluconazole to disrupt microbial growth is tied to its ability to suppress ergosterol biosynthesis. 4 Importantly, mefentrifluconazole is thought to exhibit satisfactory environmental compatibility, as it does not cause any genotoxicity, teratogenicity, neurotoxicity, reproductive toxicity, carcinogenicity, or endocrine interference in mammals, nor can it readily enter the groundwater via leaching owing to its strong adsorption capabilities, volatility, and poor water solubility. 2 Given these advantages, mefentrifluconazole has emerged as the new triazole fungicide benchmark owing to its low risk of potential harm to humans or other animals.…”

“…1] is a novel isopropanol‐triazole fungicide that was developed in 2018 by BASF and that is now widely employed to control a range of fungal crop diseases owing to its high levels of broad‐spectrum efficacy. Mefentrifluconazole use has been registered in over 60 countries and applied for at least 40 crops, with four registered products and eight such crops in China (potatoes, tomatoes, oranges, bananas, apples, grapes, cucumbers, and mangoes) 4,5 . The ability of mefentrifluconazole to disrupt microbial growth is tied to its ability to suppress ergosterol biosynthesis 4 .…”

“…Mefentrifluconazole use has been registered in over 60 countries and applied for at least 40 crops, with four registered products and eight such crops in China (potatoes, tomatoes, oranges, bananas, apples, grapes, cucumbers, and mangoes) 4,5 . The ability of mefentrifluconazole to disrupt microbial growth is tied to its ability to suppress ergosterol biosynthesis 4 . Importantly, mefentrifluconazole is thought to exhibit satisfactory environmental compatibility, as it does not cause any genotoxicity, teratogenicity, neurotoxicity, reproductive toxicity, carcinogenicity, or endocrine interference in mammals, nor can it readily enter the groundwater via leaching owing to its strong adsorption capabilities, volatility, and poor water solubility 2 .…”

Synthesis and Biological Evaluation of 1,2,4-Triazole Thioethers as Both Potential Virulence Factor Inhibitors against Plant Bacterial Diseases and Agricultural Antiviral Agents against Tobacco Mosaic Virus Infections

“…Elaborate observations found that the triazole skeleton serving as the key pharmacophore has been steadily explored and developed in the discovery of new pesticides. For instance, the representative systemic triazole fungicides, including triadimefon, difenoconazole, triadimenol, propiconazole, tetraconazole, diniconazole, mefentrifluconazole, and myclobutanil, have become a kind of most commonly used agrochemicals against fungal infections of crops. In a variety of triazole scaffolds, 1,2,4-triazole was widely concerned in view of the multipurpose biological effects after hybridization of this versatile core. − Especially, the attractive antimicrobial and antiviral profiles were normally empowered to its derivatives (Figure ).…”

Beneficial Microorganisms to Control the Gray Mold of Grapevine: From Screening to Mechanisms

“…To overcome the difficulties previously stated, it is urgent to search for alternative, effective, and eco-friendly strategy of disease control [ 19 , 20 , 21 ]. Thus, in recent years, the use of microbes as a biocontrol agent is gaining interest in agriculture [ 22 ].…”