Evaluation of the antidiabetic properties of S-1708 mulberry variety

Abstract

Background:Diabetes is a metabolic disease prevalent worldwide in all age group of people. The source of diabetes is due to an oxidation process that can produce free radicals. An increase in oxidative free radicals in the body is reported to be one of the several causes of diabetes. The best remedy to combat oxidative stress is the use of antioxidants, which inhibit and scavenge free radicals.Aim:This study has been undertaken to evaluate the antioxidant activity and antidiabetic effect of mulberry leaf extract in diabetic mice.Materials and Methods:Antioxidant activity of mulberry leaves was determined by 2,2-diphenyl-1-picryl-hydrazyl (DPPH) and ferric reducing/antioxidant power (FRAP) assay. Antidiabetic assay of mulberry leaf extract was analyzed by oral administration of leaf extract up to 3 weeks in diabetic mice induced by streptozotocin.Results:In vitro antioxidant activity in both DPPH and FRAP assays showed significantly (P < 0.05) higher inhibition of free radicals than that with ascorbic acid. Diabetic mice fed with mulberry leaf extract showed increment (+25.88%) in body weight and a significant reduction in blood glucose concentration (−71.58%). Further, glucose-6-phosphate dehydrogenase enzyme activity was significantly (P < 0.05) increased, whereas activities of other enzymes particularly catalase, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase were decreased in diabetic mice after oral administration of mulberry leaf extracts. Histology of liver revealed regeneration of hepatocytes, central vein, and nucleus.Conclusion:This study demonstrated that S-1708 mulberry variety has a potential therapeutic value in diabetes and related complications.SUMMARY Diabetes mellitus is a grave metabolic deviations and responsible for many complications affecting various organs in the human body. In spite of the known antidiabetic medicine available in the market, diabetes and the associated impediments sustained to be a major medical crisis. Medicinal plants have been proven to be useful in diabetes due to their rich therapeutic value. In the current study, S-1708 mulberry variety not only authenticated the earlier results obtained from other medicinal plants but also turn out to be known as a potential source for treating diabetes by demonstrating tremendous ant- diabetic properties. Abbreviations used: S-1708, DPPH, FRAP.

Protective Effects of Anthocyanin Extract from Purple Sweet Potato (Ipomoea batatas L.) on Blood MDA Levels, Liver and Renal Activity, and Blood Pressure of Hyperglycemic Rats

“…Consistent with our results, previous studies have reported that anthocyanin decreases SGOT and SGPT in diabetic mice ( Alli et al, 2017 ; Ranjan et al, 2017 ). For example, anthocyanin in the form of cyanidin 3-caffeoyl- p -hydroxybenzoylsophoroside-5-glucoside inhibited hepatic glucose secretion in hyperglycemic mice.…”

Effects of unaltered and bioconverted mulberry leaf extracts on cellular glucose uptake and antidiabetic action in animals

“…Recent studies have reported several pharmacological effects of mulberry leaves, including blood pressure stabilization [3], cholesterol reduction [4], thrombolysis [5], antioxidation [6], and antiobesity [7–9]. In particular, a number of human [10, 11] or animals [12–16] studies have reported to confirm the antidiabetic activity of mulberry extract by regulating blood glucose level.…”

Planting conditions can enhance the bioactivity of mulberry by affecting its composition

“…Bai et al found that mulberry extract had a protective effect on the increase of ROS and vascular endothelial damage caused by high sugar and high fat (Bai et al, 2021). Ranjan et al found that mulberry extract could achieve its antioxidant effect by reducing the activities of catalase, serum glutamic oxaloacetic transaminase, and serum glutamic pyruvic transaminase in mice used as diabetes models (Ranjan et al, 2017). This research found that the mulberry branch and mulberry leaf had highly similar bioactivities, and the antioxidant and antiapoptotic effects of the mulberry branch were even greater than the mulberry leaf (Figures 2B and 3B).…”