Evaluation of the anticonvulsant effect of Centella asiatica (gotu kola) in pentylenetetrazol-induced seizures with respect to cholinergic neurotransmission

Anticonvulsant and antioxidative activity of hydroalcoholic extract of tuber of Orchis mascula in pentylenetetrazole and maximal electroshock induced seizures in rats

“…Decrease in AChE activity in hippocampus and mid brain, 30 min after a flurothyl-induced convulsion, PTZ induced seizures and 2 min after convulsion induced electrically have also been reported (Appleyard et al, 1986;Visweswari et al, 2010). In agreement with earlier studies, our results also showed decrease in AChE and BChE activity following PTZ and MESinduced seizure.…”

Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases

“…Impairment in learning and memory consequent to epileptic seizures is reported to be caused in part due to changes in a variety of central neurotransmissions including cholinergic transmission [166] (Figure 6D). In addition, recent studies in transgenic AD mouse models with high levels of Aβ peptide suggested that seizures occur much earlier than had been expected relative to the progression of Aβ peptide accumulation and amyloid pathology [167][168][169].…”

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“…The active principles of the leaves of plant were extracted into Chloroform, since this solvent was predominantly used by several investigators for extracting anticonvulsant principle(s) from various plants 11,12 . Powdered plant material was soaked in methanol for 2 days at room temperature and the solvent was filtered.…”