Evaluation of the Antibiotic Resistance Pattern at the Medical Services Administration Hospital in Khartoum, Sudan, 2021

Abdellatif, Ashraf O.; Ali, Inas N.; Mohamed, Maha; Ibrahim, Maisoon A.; Mohamed, Wlaa A.

doi:10.55544/jrasb.1.4.6

Cited by 3 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 46 Further, another study reported that the antibiotic misuse found in their study was consistent with the city profile of antibiotic resistance. 13 In Sudan, O. Abdellatif et al 47 has reported that some bacteria including Klebsiella pneumonia, Staphylococcus aureus , and E. coli were highly resistant to cefixime by more than 90% of the total cases of the study. Also, a study conducted in Khartoum state has documented an increased resistance of the isolated bacteria to penicillin, cephalosporins, macrolide, and fluoroquinolones.…”

Section: Discussionmentioning

confidence: 94%

The Extent of Antibiotic Dispensing in Self-Medication Encounters in Sudan: A Simulated Patient Study Focusing on Cefixime Sale

Hamadouk,

Alshareif,

Ibrahim

et al. 2023

IPRP

View full text Add to dashboard Cite

Background Antibiotics play an important role in decreasing morbidity and mortality worldwide. However, inappropriate use of them by patients or healthcare professionals contributes to their resistance rendering them less efficacious. Community pharmacists (CPs) have a significant part in reducing antibiotic resistance. Therefore, this study aimed to investigate the dispensing of antibiotics without prescription in community pharmacies with an emphasis on cefixime dispensing. Methods A cross-sectional, simulated patient (SP) study was conducted in the Khartoum locality. A total of 238 community pharmacies were randomly chosen using simple random sampling. One scenario of uncomplicated urinary tract infection was designed, and six female pharmacy students who were trained to act as SPs presented the scenario. Descriptive statistics were applied to report the study outcomes. Results In the 238 pharmacy visits, at least one antibiotic was dispensed without a prescription in 69.3% of the simulated visits. Among the dispensed antibiotics, ciprofloxacin was the most dispensed antibiotic followed by cefixime representing 51.5% and 41.8%, respectively, of total dispensed antibiotics. Cefixime was dispensed as a first choice by CPs in 29% of the visits, and in the rest of the visits, only 37.3% of CPs refused to dispense cefixime after SP demand. Conclusion The findings revealed a high rate of antibiotics dispensing without prescription by CPs in Khartoum state, and cefixime was obtained with ease before and after the patient’s demand. Urgent corrective actions such as imposing strict regulations, monitoring pharmacists’ practice, and endorsing educational programs for pharmacists are needed to prevent inappropriate antibiotic dispensing practices.

show abstract

Section: Discussionmentioning

confidence: 94%

The Extent of Antibiotic Dispensing in Self-Medication Encounters in Sudan: A Simulated Patient Study Focusing on Cefixime Sale

Hamadouk,

Alshareif,

Ibrahim

et al. 2023

IPRP

View full text Add to dashboard Cite

show abstract

“…In Sudan, there was a significant resistance rate to most antibiotics frequently used in hospitals. 9 However, extensive use of both broad-and narrow-spectrum antibiotics in ICU may develop resistant strains of bacteria and other pathogens. 10 Antibiotic resistance within the ICU is very high because nosocomial infections require multiple antimicrobial therapies.…”

Section: Introductionmentioning

confidence: 99%

Impact of Irrational Use of Antibiotics Among Patients in the Intensive Care Unit on Clinical Outcomes in Sudan

Abdelkarim,

Abubakar,

Taha

et al. 2023

IDR

View full text Add to dashboard Cite

Background: Intensive Care Unit (ICU) is a specialized ward where critically ill patients are admitted to provide intensive health care Inappropriate antimicrobial therapy (AMT) and high mortality rates were documented in the ICU. The influence of irrational use of empiric antibiotics on clinical outcomes in ICU patients is not well studied in Sudan. Aim: This study aims to determine the rational use of antibiotics and its impact on clinical outcomes among ICU patients. Methods: Using data collection form, a retrospective longitudinal study was conducted among ICU patients at Omdurman Military Hospital, Khartoum State. Patients admitted from January 2019 to December 2019 were included in the study. Patients who stayed in ICU < 48 hr were excluded. Appropriateness of AMT is assessed using culture sensitivity test (CST) and the American Society of Infectious Diseases (IDSA) guideline. Results: Among 102 patients, 54.9% male, one-third of patients developed nosocomial infections, 80.4% received empiric therapy with broad-spectrum antibiotics. The CST is done in 19%, and 43% patients are prescribed inappropriate AMT. Inappropriate AMT is associated with recurrent infections 38.4% (p=0.028) and high mortality 33.8% (p=0.014). Overall mortality rate 63.7% ICU patients. Elevated mortality in nosocomial 57.8%, decreased with inappropriate AMT in 21.6% patients. Significantly higher mortality rates 90.7% among uncontrolled infections (p<0.001), 80.6% nosocomial infections (p=0.001), and 76.7% renal compromised (p=0.002). Conclusion: Empirical AMT reduces the frequency of nosocomial infections, which has an impact on mortality. Inappropriate AMT is significantly associated with uncontrolled infections and lower mortality. Implementing a restrictive infectious control system and effective stewardship programs in hospital ICU wards is recommended.

show abstract

Antimicrobial resistance, biofilm formation, and molecular detection of efflux pump and biofilm genes among Klebsiella pneumoniae clinical isolates from Northern Jordan

Swedan,

Aldakhily

2024

Heliyon

View full text Add to dashboard Cite

Evaluation of the Antibiotic Resistance Pattern at the Medical Services Administration Hospital in Khartoum, Sudan, 2021

Cited by 3 publications

References 17 publications

The Extent of Antibiotic Dispensing in Self-Medication Encounters in Sudan: A Simulated Patient Study Focusing on Cefixime Sale

The Extent of Antibiotic Dispensing in Self-Medication Encounters in Sudan: A Simulated Patient Study Focusing on Cefixime Sale

Impact of Irrational Use of Antibiotics Among Patients in the Intensive Care Unit on Clinical Outcomes in Sudan

Antimicrobial resistance, biofilm formation, and molecular detection of efflux pump and biofilm genes among Klebsiella pneumoniae clinical isolates from Northern Jordan

Contact Info

Product

Resources

About