Evaluation of the antiadhesion potential of UV cross-linked gelatin films in a rat abdominal model

Matsuda, Shunji; Se, Naomi; Iwata, Hiroo; Ikada, Yoshito

doi:10.1016/s0142-9612(01)00418-5

Cited by 60 publications

(45 citation statements)

References 12 publications

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“…Crosslinking is accomplished using chemicals such as formaldehyde 24) and glutaraldehyde 25) or physical methods such as UV irradiation 26) and heating [18][19][20] . However, it has been reported that with chemical crosslinking, cytotoxicity of residual reactants from the chemical treatment causes issues 24,25,27) .…”

Section: Discussionmentioning

confidence: 99%

Release properties of atelocollagen-gelatin complexes as carriers for local administration of fluvastatin

et al. 2017

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The aim of this study was to investigate properties of atelocollagen/gelatin complexes (AC/Gel) and their characteristics of sustained statin release, to assess the utility of AC/Gel. AC/Gel were prepared by changing the mixing ratio of AC (0 to 40% of AC). Analysis of spectra of fluvastatin (Flu), gelatin (Gel), and Flu with Gel complex using a Fourier transform-infrared spectrometer indicates that Flu was bound to Gel through a bond involving the carboxyl and amino groups. Evaluation of characteristics of sustained release of Flu from the AC/Gel using an ultraviolet-visible spectrophotometer showed that the release rate of Flu decreased with increasing the AC content. The histological evaluation using of Sprague-Dawley rats suggest that, unlike the pure Gel sponge, the AC/Gel was not absorbed in an early stage. Therefore, the present study showed that sustained Flu release can be controlled by using an AC/Gel, suggesting the utility of this composite material.

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Section: Discussionmentioning

confidence: 99%

Release properties of atelocollagen-gelatin complexes as carriers for local administration of fluvastatin

et al. 2017

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“…This is well within the range of depressed plasminogen activator activity level [ 12 ] . Matsuda et al also found that 2-day application of the antiadhesive material, poly(vinyl alcohol) fi lm, reduced the incidence rate of adhesions from 90 to 18% in rats [ 13 ] .…”

Section: Materials To Prevent Adhesionsmentioning

confidence: 95%

“…UV cross-linked gelatin fi lms were investigated for use as an antiadhesive material [ 13 ] . As shown in Fig.…”

Section: Gelatin-based Materialsmentioning

confidence: 99%

Barriers to Prevent Tissue Adhesion

Suzuki

Ikada

2011

Biomaterials for Surgical Operation

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Adhesion often occurs after surgery, especially in abdominal, gynecological, and thoracic surgeries. It can cause serious postsurgical complications such as infertility, chronic pelvic pain, and diffi culties of extensive adhesiolysis in future surgery. Antiadhesive barriers have been developed to provide physical separation between the injured site and the adjacent tissues. Since physical separation is only required during the critical time of wound healing of the damaged area, bioabsorbable polymers have been found to be appropriate. A range of adhesion barriers are commercially available in the forms of solutions, gels, and sheets. Their characteristics and limitations are discussed in this chapter. Recent investigations are also described on newly developed devices that show promising performance such as ease of handling and more effective reduction of adhesion.

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“…Attributable to the excellent biocompatibility and biodegradability [2,3] , gelatin has been widely used in biomedical materials for controlled drug release. In this application, can be found gelatin in different forms: films [4][5][6] , disks [7] , hydrogels [8,9] , sponges [10] and frequently microspheres [7,9,[11][12][13][14] . Microspheres are usually prepared by water-in-oil emulsion.…”

Section: Introductionmentioning

confidence: 99%

Potential doxorubicin delivery system based on magnetic gelatin microspheres crosslinked with sugars

2018

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ObstractThe preparation and characterization of magnetic microspheres based on gelatin for use in drug delivery systems are reported. Sugars were employed as crosslinking agents and type A gelatin and type B gelatin were compared to prepare microspheres by water-in-oil emulsion. The influence of gelatin and sucrose concentration, temperature and stirring speed on microbeads' characteristics was studied. The gelatin concentration and stirring speed were the parameters directly associated with the particle sizes. We found no relevant difference between the use of type A and type B gelatin. In addition, the gelatin crosslinking study revealed that sucrose is not a crosslinking agent but fructose can crosslink the protein chains when the reaction medium has pH 9. The size of the microspheres varied from 5 to 60 μm as measured by optical microscopic images. Doxorubicin adsorption and release were successfully performed using the microspheres crosslinked with fructose under the action of an external magnetic field. It was observed that the microspheres absorbed 69% of the doxorubicin that was in solution. After 24 h, about 45% of the DOX was displaced from microspheres to saline medium in the free form in the solution.

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Evaluation of the antiadhesion potential of UV cross-linked gelatin films in a rat abdominal model

Cited by 60 publications

References 12 publications

Release properties of atelocollagen-gelatin complexes as carriers for local administration of fluvastatin

Release properties of atelocollagen-gelatin complexes as carriers for local administration of fluvastatin

Barriers to Prevent Tissue Adhesion

Potential doxorubicin delivery system based on magnetic gelatin microspheres crosslinked with sugars

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