Evaluation of the anti-Trypanosoma cruzi activity in vitro and in vivo of silibinin and silibinin in association to benznidazole

Torchelsen, Fernanda Karoline Vieira da Silva; Silva, Thaila Martins; Milagre, Matheus Marques; Silva, Rafael Rodrigues; Reis, Levi Eduardo Soares; Branquinho, Renata Tupinambá; Silva, Glenda Nicioli; Lana, Marta de

doi:10.1007/s00436-020-06944-5

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“…Benznidazole (BNZ) was used as positive control and tested at a single concentration of 260 μg/mL (i.e. 100 μM BNZ) to enable the complete inhibition of trypomastigote viability, based on previous results with T. cruzi Y strain ( Torchelsen et al, 2021 ). Positive controls (260 μg BNZ/mL, 0.1% DMSO in well) and negative controls (0.1% DMSO) were run in triplicates at similar conditions.…”

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confidence: 99%