Evaluation of the anti-inflammatory properties of telmesteine on inflammation-associated skin diseases

Xu, Xuetao; Huang, Dan-Ying; Liu, Wenfeng; Sheng, Zhaojun; Liang, Kanyi; Li, Dongli; Zhao, Deng-Gao; Ma, Yanyan; Zhang, Kun; Hayat, Tasawar; Alharbi, Njud S.; Li, Weikuai

doi:10.1039/c7ra01111c

Cited by 9 publications

(5 citation statements)

References 39 publications

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“… 2010 ; Xu et al. 2017 ). To avoid the interference of vehicle and solvent used in this study, we applied the same vehicle and solvent to control group and comparison ears, respectively.…”

Section: Discussionmentioning

confidence: 99%

Extract of Pinus densiflora needles suppresses acute inflammation by regulating inflammatory mediators in RAW264.7 macrophages and mice

Jeong

Choi

Kwon

et al. 2022

Pharmaceutical Biology

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Context Pinus densiflora Siebold & Zucc. (Pinaceae) needle extracts ameliorate oxidative stress, but research into their anti-inflammatory effects is limited. Objective To investigate antioxidant and anti-inflammatory effects of a Pinus densiflora needles (PINE) ethanol extract in vitro and in vivo . Materials and methods We measured levels of reactive oxygen species (ROS), superoxide dismutase (SOD) and inflammatory mediators in lipopolysaccharide (LPS)-stimulated RAW264.7 cells at various PINE concentrations (25, 50 and 100 μg/mL; but 6.25, 12.5 and 25 μg/mL for interleukin-1β and prostaglandin E 2 (PGE 2 )). Thirty ICR mice were randomized to six groups: vehicle, control, PINE pre-treatment (0.1, 0.3 and 1 mg/left ear for 10 min followed by arachidonic acid treatment for 30 min) and dexamethasone. The posttreatment ear thickness and myeloperoxidase (MPO) activity were measured. Results PINE 100 μg/mL significantly decreased ROS (IC 50 , 70.93 μg/mL, p < 0.01), SOD (IC 50 , 30.99 μg/mL, p < 0.05), malondialdehyde ( p < 0.01), nitric oxide (NO) (IC 50 , 27.44 μg/mL, p < 0.01) and tumour necrosis factor-alpha ( p < 0.05) levels. Interleukin-1β ( p < 0.05) and PGE 2 ( p < 0.01) release decreased significantly with 25 μg/mL PINE. PINE 1 mg/ear inhibited LPS-stimulated expression of cyclooxygenase-2 and inducible NO synthase in RAW264.7 macrophages and significantly inhibited ear oedema (36.73–15.04% compared to the control, p < 0.01) and MPO activity (167.94–105.59%, p < 0.05). Discussion and conclusions PINE exerts antioxidant and anti-inflammatory effects by inhibiting the production of inflammatory mediators. Identified flavonoids such as taxifolin and quercetin glucoside can be attributed to effect of PINE.

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“… 2010 ; Xu et al. 2017 ). To avoid the interference of vehicle and solvent used in this study, we applied the same vehicle and solvent to control group and comparison ears, respectively.…”

Section: Discussionmentioning

confidence: 99%

Extract of Pinus densiflora needles suppresses acute inflammation by regulating inflammatory mediators in RAW264.7 macrophages and mice

Jeong

Choi

Kwon

et al. 2022

Pharmaceutical Biology

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“…67 Tumor Necrosis Factor-a (TNF-a) is a major pro-inammatory cytokine involved in early inammatory events. 68 Based on a 3D-human microvascular model, we saw that TNF-a triggered a series of inammatory responses, which included the upregulation of ROS, endothelial NO and IL-6 ( Fig. 7B, D and F).…”

Section: Measurement Of Fpm Induced Endothelial Dysfunction Based On mentioning

confidence: 93%

Functional human 3D microvascular networks on a chip to study the procoagulant effects of ambient fine particulate matter

Wang

et al. 2017

RSC Adv.

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“…Also, topical application of croton oil triggers local inflammation, inducing edema and erythema, also increasing vascular permeability, leukocytes infiltration, synthesis of eicosanoids, and liberation of histamine and serotonin [ 19 ]. In addition, croton oil induces skin inflammation, activating an enzymatic cascade, including phospholipase A 2 (PLA 2 ), which further induces the releasing of arachidonic acid (AA), prostaglandins, and platelet activation factor [ 30 , 31 ]. Corticosteroids, such as dexamethasone, present significant anti-inflammatory effects in this croton oil model, as well as COX and 5-LOX inhibitors and leukotriene B4 (LTB4) antagonists [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Baccharis dracunculifolia DC (Asteraceae) Root Extract and Its Triterpene Baccharis Oxide Display Topical Anti‐Inflammatory Effects on Different Mice Ear Edema Models

Ferreira

Queiroz

Facchini

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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B. dracunculifolia is popularly used to treat skin diseases. This work aimed to evaluate the topical anti-inflammatory properties of B. dracunculifolia root extract (BdR) and its major compound baccharis oxide (BOx) on mice ear edema models. BdR was analyzed by GC-MS, and BOx was isolated by chromatographic fractionation. Topical anti-inflammatory activities were determined by using the croton oil, capsaicin, histamine, and phenol-induced mouse ear edema models. N-acetyl-β-D- glucosaminidase (NAG) and myeloperoxidase (MPO) activities, as well as NO dosage and histopathological analyses, were also evaluated. Phytochemical analysis of BdR showed BOx as one of the major constituents. BdR and BOx (both at 0.1, 0.5, and 1.0 mg/ear) significantly reduced croton oil, histamine, and phenol-induced ear edema, while only BOx was effective in reducing capsaicin-induced edema. MPO and NAG activities, as well as NO production, were significantly inhibited by BdR and BOx. Histopathological analysis confirmed the topical anti-inflammatory properties of BdR and BOx. Our findings showed that BdR and BOx demonstrated significant topical anti-inflammatory effects in mouse ear edema induced by different agents, suggesting their possible application on skin inflammatory diseases.

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Evaluation of the anti-inflammatory properties of telmesteine on inflammation-associated skin diseases

Abstract: Telmesteine, a useful agent for respiratory tract disorders, has been reported to be a critical active ingredient in topical compositions for dermatitis.

Cited by 9 publications

References 39 publications

Extract of Pinus densiflora needles suppresses acute inflammation by regulating inflammatory mediators in RAW264.7 macrophages and mice

Extract of Pinus densiflora needles suppresses acute inflammation by regulating inflammatory mediators in RAW264.7 macrophages and mice

Functional human 3D microvascular networks on a chip to study the procoagulant effects of ambient fine particulate matter

Baccharis dracunculifolia DC (Asteraceae) Root Extract and Its Triterpene Baccharis Oxide Display Topical Anti‐Inflammatory Effects on Different Mice Ear Edema Models

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