Evaluation of the anti-inflammatory and anti-proliferation tumoral cells activities of Antrodia camphorata, Cordyceps sinensis, and Cinnamomum osmophloeum bark extracts

Rao, Yerra Koteswara; Fang, Shih-Hua; Tzeng, Yew‐Min

doi:10.1016/j.jep.2007.07.028

Cited by 123 publications

(81 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some synthesised and commercial compounds with positive anti-inflammatory potential have been reported (Table 7). Taofiq et al (2015) Tzeng, 2007;Rao, Fang, Wu, & Tzeng, 2010;Han, Oh, & Park, 2011). This mushroom contains a lot of bioactive compounds and "Cordycepin" an adenosine analogue is the most important one.…”

Section: Commercial and Synthesised Compoundsmentioning

confidence: 99%

Anti-inflammatory potential of mushroom extracts and isolated metabolites

Taofiq

Martins

Barreiro

et al. 2016

Trends in Food Science & Technology

105

View full text Add to dashboard Cite

Background: In the recent years natural resources are being in focus due to their great potential to be exploited in the discovery/development of novel bioactive compounds and, among them, mushrooms can be highlighted as alternative sources of anti-inflammatory agents. Scope and approach:The present review reports the anti-inflammatory activity of mushroom extracts and of their bioactive metabolites involved in this bioactive action.Additionally the most common assays used to evaluate mushrooms anti-inflammatory activity were also reviewed, including in vitro studies in cell lines, as well as in animal models in vivo. Key findings and conclusions:The anti-inflammatory compounds identified in mushrooms include polysaccharides, terpenes, phenolic acids, steroids, fatty acids and other metabolites.Among them, polysaccharides, terpenoids and phenolic compounds seem to be the most important contributors to the anti-inflammatory activity of mushrooms as demonstrated by numerous studies. However, clinical trials need to be conducted in order to confirm the effectiveness of some of these mushroom compounds namely, inhibitors of NF-κB pathway and of cyclooxygenase related with the expression of many inflammatory mediators.

show abstract

Section: Commercial and Synthesised Compoundsmentioning

confidence: 99%

Anti-inflammatory potential of mushroom extracts and isolated metabolites

Taofiq

Martins

Barreiro

et al. 2016

Trends in Food Science & Technology

105

View full text Add to dashboard Cite

show abstract

“…However, when inflammation is uncontrolled, it leads to chronic inflammatory and autoimmune diseases (Rao et al, 2007). Extensive investigations within the last two decades revealed that most chronic illnesses including cancer, neurological, autoimmune, diabetes, and cardiovascular diseases are mediated through inflammation.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect ofCareya arboreaon inflammatory biomarkers in carrageenan-induced inflammation

Begum

Sharma

Pillai

et al. 2014

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Careya arborea Roxb. (Lecythidaceae) has multiple applications in traditional medicine; it exhibits analgesic, antibacterial, anti-inflammatory, antiulcer, and protective effects. However, the effect of C. arborea on biochemical and immmunological inflammatory mediators has not been explored. Objective: The present study investigates the anti-inflammatory potential of the methanol extract of C. arborea stem bark and further assesses its possible mechanism on the modulation of inflammatory biomarkers. Materials and methods: Anti-inflammatory activity of C. arborea methanol extract (CAME) was evaluated (100 and 200 mg/kg, p.o) using indomethacin (10 mg/kg, p.o) as the standard drug in Wistar albino rats. Inflammation was induced by injecting 0.1 ml carrageenan (1% w/v) into the left hind paw. The anti-inflammatory mechanism was studied by measuring malondialdehyde (MDA), C-reactive protein (CRP), nitric oxide (NO), myeloperoxidase (MPO), TNF-a, and IL-1b levels in both control and treated groups. A protocol has also been established to quantify quercetin and betulinic acid content in CAME using HPTLC fingerprint. Results: Careya arborea significantly (p50.001) decreased carrageenan-induced paw edema, showed a reduction of 48.87 and 65.53% at doses of 100 and 200 mg/kg, respectively. Moreover, CAME significantly decreased the MDA, CRP, NO, and MPO levels, elevated by carrageenan induced inflammation. CAME also markedly down-regulated serum TNF-a and IL-1b levels. These findings were further supported by the histological study. The content of quercetin and betulinic acid in CAME was found to be 0.177 and 3.14%, respectively. Conclusion: Several mechanisms, including the inhibition of pro-inflammatory cytokines, enzymes and mediators release, appear to account for the anti-inflammatory potential of C. arborea.

show abstract

“…Meanwhile, the highest dose of A. camphorata (>100 µg/mL) was used to treat normal human endothelial cells for 24 hours, there was no cytotoxic effects were found. Furthermore, the chloroform extracts of fruiting bodies of A. camphorata significantly inhibited the growth of human breast cancer (MCF-7) cells with an IC 50 value of 65 µM (Rao et al, 2007). This indicated the differential cytotoxic effects of A. camphorata crude extract on different kinds of breast cancer cells, with no harmful effects on normal cells at higher concentrations (Hseu et al, 2002).…”

Section: A Camphorata Regulates Apoptosis and Cell Survivalmentioning

confidence: 89%