Evaluation of the anti-diarrheal activity of the hydromethanolic root extract of Rhus tripartita (Ucria) (Anacardiacae)

Barka, Zaineb Ben; Aouadhi, Chedia; Tlili, Mounira; Alimi, Hichem; Miled, Hanène Ben; Rhouma, Khémaïs Ben; Sakly, Mohsen; Ksouri, Riadh; Schneider, Yves Jacques; Maaroufi, Abderrazak; Tebourbi, Olfa

doi:10.1016/j.biopha.2016.07.055

Cited by 16 publications

(10 citation statements)

References 39 publications

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“…Currently, food scientists and nutrition specialists suggest that these phytochemicals found in the plant offer many health benefits when consumed as part of the usual diet. Concerning the chemical studies of this plant, several compounds such as flavonoids, biflavonoids, isobiflavonoids, catechin, epicatechin-3-O-gallate, proanthocyanidin oligomers and polymers, polysaccharides, condensed tannins have been isolated from this plant and found to be responsible of several biological activities such as anti-inflammatory, antiulcerogenic, antimalarial, antimicrobial, antitumor [27,28,29,30].…”

Section: Introductionmentioning

confidence: 99%

Biochemical profile and in vitro biological activities of extracts from seven folk medicinal plants growing wild in southern Tunisia

et al. 2019

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Recently, much attention has been paid to the extracts obtained from plant species in order to analyse their biological activities. Due to the climate diversity in Tunisia, the traditional pharmacopoeia consists of a wide arsenal of medicinal plant species since long used in folk medicine, in foods as spices, and in aromatherapy. Although many of these species are nearly facing extinction, only a small proportion of them have been scientifically studied. Therefore, this study explores the biochemical properties of seven spontaneous plants, which were harvested in the arid Tunisian desert: Marrubium vulgare (L.), Rhus tripartita (Ucria) D.C., Thymelaea hirsute (L.) Endl., Plantago ovata (Forsk.), Herniaria fontanesii (J. Gay.), Ziziphus lotus (L.) and Hyoscyamus albus (L.). Extracts from these plants were found to contain different types of secondary metabolites (polyphenols, flavonoids, condensed tannins, crude saponins, carotenoids and alkaloids) that are involved in important biological activities. The biological activity of the extracts obtained from each Tunisian plant was assessed: first of all, leukaemia and colon cancer cell lines (K-562 and CaCo-2 respectively) were treated with different concentrations of extracts, and then the anti-proliferative activity was observed. The results showed, in particular, how the plant extract from Rhus tripartita significantly inhibits cell proliferation, especially on the K-562 tumour cell line. Subsequently, the anti-inflammatory activity was also assessed, and the results showed that Herniaria fontanesii and Marrubium vulgare possess the highest activity in the group of analysed plants. Finally, the greatest acetylcholinesterase inhibitory effect was exhibited by the extract obtained from Rhus tripartita.In conclusion, all the Tunisian plants we analysed were shown to contain a remarkable amount of different bio-active compounds, thus confirming their involvement in several biological activities. Rhus tripartita and Ziziphus lotus were shown to be particularly effective in anti-proliferative activity, while Herniaria fontanesii were shown to have the best anti-inflammatory activity.

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Section: Introductionmentioning

confidence: 99%

Biochemical profile and in vitro biological activities of extracts from seven folk medicinal plants growing wild in southern Tunisia

et al. 2019

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“…1g/kg completely inhibited the intestinal transit [54]. Protein tannates produced by tannin by denaturation of protein make intestinal mucosa more resistant and reduce secretion [55].…”

Section: Discussionmentioning

confidence: 94%

Phytochemical and biological screening of Lantana camara linn. leaves extract

Pandeya

Sharma

Basyal

2022

J. Nepal Chem. Soc.

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The current study evaluated the phytochemical and biological screening of Lantana camara (Verbenaceae). It is a highly invasive ornamental garden plant species, native to tropical and sub-tropical America. Leaves of L. camara were extracted successively by petroleum ether and methanol by continuous hot percolation. The phytochemical screening was carried out by color reaction with different reagents. The Well diffusion method on Mueller Hinton agar was used for evaluating antimicrobial activity. The LD50 value was determined by acute toxicity studies. The analgesic activity was carried out by tail immersion method, antimotility activity was carried out by charcoal movement test and the antidiabetic activity was carried out by oral glucose tolerance test. The extractive value of methanolic and petroleum ether was found to be 10.11% and 3.11% respectively. The preliminary phytochemical screening showed a positive reaction test for glycoside, tannin, saponin, steroid, flavonoid, carbohydrates, diterpene, and triterpene. The extract showed significant antimicrobial activity against S. aureus (p<0.05) and didn't show any activity against E. coli. The LD50 value was found above 2000mg/kg. The analgesic, antimotility and antidiabetic activity of plant extract showed significant results in a dose-dependent manner (p<0.05). The study revealed that the plant possessed antibacterial, analgesic, antimotility and antidiabetic activity. Further studies are needed to standardize the extract and evaluation of the safety profile in long-term toxicity studies is recommended

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“…Plant extracts are multicomponent systems, and some have bioactive effects such as hepatoprotective and antioxidant properties in vivo against EtOH-induced toxicity [9,10]. For R. tripatita, we have previously shown that the root bark extract protects over EtOH-induced ulcer in rats, [11] while others demonstrated its antifungal and antibacterial properties [4,6].…”

Section: A C C E P T E Dmentioning

confidence: 99%

“…Rhus tripartita is a local presaharan Tunisian plant located both in the semi-arid and, especially, the arid zone and its fruits can be consumed after mixing with water. R. tripartita is considered as a medicinal plant that has been used for a long time in Tunisian traditional medicine as an anti-diarrheal agent [4][5][6]. The phytochemicals (phenolic compounds, total flavonoids, condensed tannins) are responsible for the anticarcinogenic, antithrombotic and…”

Section: Introductionmentioning

confidence: 99%

A combination of NMR and liquid chromatography to characterize the protective effects of Rhus tripartita extracts on ethanol-induced toxicity and inflammation on intestinal cells

Barka

Grintzalis

Polet

et al. 2018

Journal of Pharmaceutical and Biomedical Analysis

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Consumption of ethanol may have severe effects on human organs and tissues and lead to acute and chronic inflammation of internal organs. The present study aims at investigating the potential protective effects of three different extracts prepared from the leaves, root, and stem of the sumac, Rhus tripartita, against ethanol-induced toxicity and inflammation using intestinal cells as a cell culture system, in vitro model of the intestinal mucosa. The results showed an induction of cytotoxicity by ethanol, which was partially reversed by co-administration of the plant extracts. As part of investigating the cellular response and the mechanism of toxicity, the role of reduced thiols and glutathione-S-transferases were assessed. In addition, intestinal cells were artificially imposed to an inflammation state and the anti-inflammatory effect of the extracts was estimated by determination of interleukin-8. Finally, a detailed characterization of the contents of the three plant extracts by high resolution Nuclear Magnetic Resonance (NMR) spectroscopy and mass spectrometry revealed significant differences in their chemical compositions.

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Evaluation of the anti-diarrheal activity of the hydromethanolic root extract of Rhus tripartita (Ucria) (Anacardiacae)

Cited by 16 publications

References 39 publications

Biochemical profile and in vitro biological activities of extracts from seven folk medicinal plants growing wild in southern Tunisia

Biochemical profile and in vitro biological activities of extracts from seven folk medicinal plants growing wild in southern Tunisia

Phytochemical and biological screening of Lantana camara linn. leaves extract

A combination of NMR and liquid chromatography to characterize the protective effects of Rhus tripartita extracts on ethanol-induced toxicity and inflammation on intestinal cells

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