Evaluation of the anti-arthritic activity of Cinnamomum cassia bark extract in experimental models

Sharma, Hemlata; Chauhan, Prerna; Singh, Sanjay

doi:10.1016/j.imr.2018.08.002

Cited by 29 publications

(23 citation statements)

References 46 publications

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“…Later, cinnamomulactone (0.1, 1, 10 and 100 μM), a new phytocompound from the EETC, was reported to be inhibitory to the expression of MMP-1, MMP-3 and IL-1β in rheumatoid arthritis synovial fibroblasts [49]. Moreover, in 2018, Sharma et al reported that WEBC (50, 100 and 200 mg/kg) can significantly reduce IL-1, MDA, TNF-α levels and joint swelling in a concentration-dependent manner in rats with CFA-induced and formaldehyde- induced arthritis [72].…”

Section: Pharmacologymentioning

confidence: 99%

Cinnamomum cassia Presl: A Review of Its Traditional Uses, Phytochemistry, Pharmacology and Toxicology

et al. 2019

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Cinnamomum cassia Presl is a tropical aromatic evergreen tree of the Lauraceae family, commonly used in traditional Chinese medicine. It is also a traditional spice, widely used around the world. This paper summarizes the achievements of modern research on C. cassia, including the traditional uses, phytochemistry, pharmacology and toxicology. In addition, this review also discusses some significant issues and the potential direction of future C. cassia research. More than 160 chemicals have been separated and identified from C. cassia. The main constituents of C. cassia are terpenoids, phenylpropanoids, glycosides, etc. Modern studies have confirmed that C. cassia has a wide range of pharmacological effects, including antitumour, anti-inflammatory and analgesic, anti-diabetic and anti-obesity, antibacterial and antiviral, cardiovascular protective, cytoprotective, neuroprotective, immunoregulatory effects, anti-tyrosinase activity and other effects. However, the modern studies of C. cassia are still not complete and more in-depth investigations need to be conducted in alimentotherapy, health product, toxicity and side effects, and more bioactive components and potential pharmacological effects need to be explored in the future.

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Section: Pharmacologymentioning

confidence: 99%

Cinnamomum cassia Presl: A Review of Its Traditional Uses, Phytochemistry, Pharmacology and Toxicology

et al. 2019

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“…Extract [83], chromone extract [84], chromones: divaricatol, ledebouriellol and hamaudol [85], polysaccharide [86] (i) Anti-inflammatory [83,84,86], (ii) Analgesic [85,87], (iii) Immunomodulatory [87] Gui zhi, Rou gui Cinnamomum cassia Presl Extracts [88][89][90], cinnamic acid [90], cinnamomulactone [91] (i) Anti-inflammatory [90], (ii) Anti-arthritic, reduces joint swelling [88], (iii) Inhibitory activity against matrix metalloproteinases [91], (iv) Improved clinical symptoms and inflammatory markers [89] Ma huang Ephedra sinica Stapf, other Ephedra spp. Polysaccharides [92,93] (i) Anti-inflammatory, immunosuppressive [92,93] Bai zhu Atractylodes macrocephala Koidz Extract [94], atractylone [95], atractylenolide I [94], atractylenolide III [96], Sesquiterpenoids [97]; three new compounds [98] (i) Anti-inflammatory [94][95][96][97][98] Chuan xiong, xiong qiong…”

Section: Syndromes In 2018 Guidelinementioning

confidence: 99%

Chinese Herbal Medicines for Rheumatoid Arthritis: Text‐Mining the Classical Literature for Potentially Effective Natural Products

Xia

May

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Rheumatoid arthritis (RA) is an autoimmune disease characterized by multijoint swelling, pain, and destruction of the synovial joints. Treatments are available but new therapies are still required. One source of new therapies is natural products, including herbs used in traditional medicines. In China and neighbouring countries, natural products have been used throughout recorded history and are still in use for RA and its symptoms. This study used text-mining of a database of classical Chinese medical books to identify candidates for future clinical and experimental investigations of therapeutics for RA. Methods. The database Encyclopaedia of Traditional Chinese Medicine (Zhong Hua Yi Dian) includes the full texts of over 1,150 classical books. Eight traditional terms were searched. All citations were assessed for relevance to RA. Results and Conclusions. After removal of duplications, 3,174 citations were considered. After applying the exclusion and inclusion criteria, 548 citations of traditional formulas were included. These derived from 138 books written from 206 CE to 1948. These formulas included 5,018 ingredients (mean, 9 ingredients/formula) comprising 243 different natural products. When these text-mining results were compared to the 18 formulas recommended in a modern Chinese Medicine clinical practice guideline, 44% of the herbal formulas were the same. This suggests considerable continuity in the clinical application of these herbs between classical and modern Chinese medicine practice. Of the 15 herbs most frequently used as ingredients of the classical formulas, all have received research attention, and all have been reported to have anti-inflammatory effects. Two of these 15 herbs have already been developed into new anti-RA therapeutics—sinomenine from Sinomenium acutum (Thunb.) Rehd. & Wils and total glucosides of peony from Paeonia lactiflora Pall. Nevertheless, there remains considerable scope for further research. This text-mining approach was effective in identifying multiple natural product candidates for future research.

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“… 28 Energy consumption stimulation by TNF-α occurs via the action of TNF-α on protein and lipid metabolisms with the resultant reduction in energy intake by provoking anorexia, thus leading to cachexia. 29 , 30 Prazosin revealed a promising inhibitory impact on the expression of inflammatory cytokine TNF-α.…”

Section: Discussionmentioning

confidence: 99%

Appraisal of the Antiarthritic Potential of Prazosin via Inhibition of Proinflammatory Cytokine TNF-α: A Key Player in Rheumatoid Arthritis

et al. 2021

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Prazosin, a selective α1 adrenergic receptor antagonist, with documented anti-inflammatory potential, was evaluated for its antiarthritic efficacy by targeting specifically TNF-α. The antiarthritic attribute of prazosin validated through in vitro screening comprised thermally provoked denaturation of bovine serum albumin (BSA) and egg albumin along with membrane stabilization evaluation at a concentration of 100–6400 μg/mL, while in vivo screening comprised formaldehyde-instigated arthritis at the doses of 5, 10, and 20 mg/kg and complete Freund’s adjuvant (CFA)-induced arthritis at 20 mg/kg dose. Paw swelling, body weight, arthritic score, hematological parameters, and histological and radiographic examination of ankle joints were assessed for a period of 28 days after CFA immunization. Moreover, the proinflammatory cytokine TNF-α level was also assessed through quantitative real-time polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). Prazosin revealed significant antiarthritic effect evident through protein denaturation inhibition in the egg albumin and the BSA model, stabilization of red blood cell membrane in the membrane stabilizing assay, and reduction in paw volume in formaldehyde-induced arthritis. Likewise, prazosin exhibited propitious antiarthritic effects in the CFA-provoked arthritis model manifested by paw volume and arthritic score alleviation, substantial weight loss prevention, and preservation of the normal hematological and biochemical profile. Histological and X-ray investigation unveiled no substantive structural alterations in treated rat’s ankle joints. The TNF-α expression level was also reduced. Thus, the current study is suggestive that prazosin exhibits a strong antiarthritic potential possibly through inhibition of TNF-α.

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Evaluation of the anti-arthritic activity of Cinnamomum cassia bark extract in experimental models

Cited by 29 publications

References 46 publications

Cinnamomum cassia Presl: A Review of Its Traditional Uses, Phytochemistry, Pharmacology and Toxicology

Cinnamomum cassia Presl: A Review of Its Traditional Uses, Phytochemistry, Pharmacology and Toxicology

Chinese Herbal Medicines for Rheumatoid Arthritis: Text‐Mining the Classical Literature for Potentially Effective Natural Products

Appraisal of the Antiarthritic Potential of Prazosin via Inhibition of Proinflammatory Cytokine TNF-α: A Key Player in Rheumatoid Arthritis

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