Evaluation of the anterior cruciate ligament, medial collateral ligament, achilles tendon and patellar tendon as cell sources for tissue-engineered ligament

Cooper, James A.; Bailey, LeeAnn O.; Carter, Janell N.; Castiglioni, Cynthia; Kofron, Michelle D.; Ko, Frank; Laurencin, Cato T.

doi:10.1016/j.biomaterials.2005.12.013

Cited by 95 publications

(90 citation statements)

References 29 publications

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“…Recently, four cellular sources from different tendon/ ligament tissue were investigated for a tissue-engineered ligament replacement [11]. The investigators suggested cells from the anterior cruciate ligament as the most suitable cells for the development of tissue-engineered ligament and tendon.…”

Section: Cell-derived Therapiesmentioning

confidence: 99%

Tendon and ligament engineering in the adult organism: mesenchymal stem cells and gene-therapeutic approaches

Hoffmann

Groß

2007

International Orthopaedics (SICO

126

122

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Tendons and ligaments are elastic collagenous tissues with similar composition and hierarchical structure, contributing to motion. Their strength is related to the number and size of the collagen fibrils. Collagen fibrils increase in size during development and in response to increased physical demands or training. Tendon disorders are commonly seen in clinical practice and give rise to significant morbidity. Treatment is difficult and patients often suffer from the symptoms for quite a long time. Despite remodelling, the biochemical and mechanical properties of healed tendon tissue never match those of intact tendon. The prerequisite for focussed treatment strategies in the future will be an improved understanding of the molecular events both in the embryo and contributing to regeneration in the adult organism. Novel approaches include the local delivery of growth factors, stem-and tendon-cell-derived therapy, the application of mechanical load and gene-therapeutic approaches based on vehicles encoding selected factors, or combinations of these. Important factors are proteins of the extracellular matrix like the metalloproteinases, growth factors like the bone morphogenetic proteins but also intracellular signalling mediator proteins, such as the Smads and transcription factors from the helix-loop-helix and other families. In this review, we focus specifically on such molecular approaches based on mesenchymal stem cells.Résumé Les tendons et les ligaments sont constitués de fibres élastiques de collagène dont la composition est similaire de même que leur structure contribuant au mouvement. Leur résistance est parallèle au nombre et à la taille des fibres collagènes. Si les fibres collagènes grossissent durant la croissance, il en est de même en réponse à une augmentation de l'entraînement physique. A titre clinique on rencontre relativement fréquemment les problèmes tendineux responsables d'une certaine morbidité. Le traitement en est difficile, les patients sont affectés sur un temps relativement long de troubles secondaires à ces lésions. En dépit du remodelage, les propriétés biomécani-ques et biochimiques d'un tendon, d'un tissu tendineux guéri ne peuvent être comparés à ceux d'un tendon sain. Les prérequis d'une stratégie thérapeutique devrait, dans le futur, permettre de mieux comprendre ce qui se passe au moment du développement embryologique et de la régén-ération au niveau de l'organisme adulte. Une nouvelle approche thérapeutique doit prendre en compte l'administration de facteurs de croissance et l'utilisation de cellules souche dans le cadre d'une thérapie génique. Les facteurs importants sont les protéines de la matrice extracellulaire comme les métalloprotéinases de même que les facteurs de croissance de type BMP mais il faut prendre en compte également les facteurs de transcriptions chromosomiques. Pour cette étude, nous nous sommes spécialement centrés sur de telles molécules et sur les cellules souches mesenchymenteuses. Structure and composition of tendons and ligaments

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Section: Cell-derived Therapiesmentioning

confidence: 99%

Tendon and ligament engineering in the adult organism: mesenchymal stem cells and gene-therapeutic approaches

Hoffmann

Groß

2007

International Orthopaedics (SICO

126

122

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“…This addition increases the complexity, as factors such as cell seeding density, adhesion, viability, and extracellular matrix production must be considered. 100,[122][123][124] Bioreactors have been used to create a controlled environment for cell and tissue cultivation.…”

Section: Tissue-engineered Constructsmentioning

confidence: 99%

Twenty‐five years of tendon and ligament research

Dourte

Kuntz

Soslowsky

2008

Journal Orthopaedic Research

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Twenty-five years ago, the Journal of Orthopaedic Research published its first volume, which included five articles covering topics in tendon and ligament research. Since then, the body of tendon and ligament research has continued to increase exponentially. This review summarizes major advancements in tendon and ligament research since the initial publication of this journal. The purpose of this article is not to provide an in-depth review of all of tendon and ligament research, but instead to provide a concise literature review of some of the major and recurring areas of research. The general topics covered over the last 25 years include tissue properties, tendinopathy, healing, and engineered scaffolds. ß

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“…Cooper et al [16] compared four cell sources used for anterior cruciate ligament (ACL) reconstruction. Cells were harvested from the ACL, medial collateral ligament (MCL), Achilles tendon, or patellar tendon.…”

Section: Chondrocytes and Fibroblastsmentioning

confidence: 99%

“…Both the isomeric forms of PLA have been tested for ligament reconstruction. Cells seeded on the PLLAbraided scaffold adhere, proliferate and exhibit ECM component production after three weeks of culture [16].…”

Section: Synthetic Polymersmentioning

confidence: 99%

Application of cell and biomaterial-based tissue engineering methods in the treatment of cartilage, menisci and ligament injuries

Trzeciak

Richter

Suchorska

et al. 2016

International Orthopaedics (SICOT)

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Over 20 years ago it was realized that the traditional methods of the treatment of injuries to joint components: cartilage, menisci and ligaments, did not give satisfactory results and so there is a need of employing novel, more effective therapeutic techniques. Recent advances in molecular biology, biotechnology and polymer science have led to both the experimental and clinical application of various cell types, adapting their culture conditions in order to ensure a directed differentiation of the cells into a desired cell type, and employing non-toxic and non-immunogenic biomaterial in the treatment of knee joint injuries. In the present review the current state of knowledge regarding novel cell sources, in vitro conditions of cell culture and major important biomaterials, both natural and synthetic, used in cartilage, meniscus and ligament repair by tissue engineering techniques are described, and the assets and drawbacks of their clinical application are critically evaluated.

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Evaluation of the anterior cruciate ligament, medial collateral ligament, achilles tendon and patellar tendon as cell sources for tissue-engineered ligament

Cited by 95 publications

References 29 publications

Tendon and ligament engineering in the adult organism: mesenchymal stem cells and gene-therapeutic approaches

Tendon and ligament engineering in the adult organism: mesenchymal stem cells and gene-therapeutic approaches

Twenty‐five years of tendon and ligament research

Application of cell and biomaterial-based tissue engineering methods in the treatment of cartilage, menisci and ligament injuries

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