Evaluation of the anterior chamber angle in pseudoexfoliation syndrome

Iwanejko, Małgorzata; Turno-Kręcicka, Anna; Tomczyk-Socha, Martyna; Kaczorowski, Kamil; Grzybowski, Andrzej; Misiuk-Hojło, Marta

doi:10.17219/acem/64023

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…Konstas et al [28] found that baseline IOP was higher in XFG patients than in POAG patients. Similar findings were reported by Tezel and Tezel [29], Lindblom and Thorburn [31], and Futa et al [32]. In addition, Teus et al [33] showed that among untreated patients, a higher level of IOP was associated with a greater loss of visual field (the MD, mean deviation coefficient, was examined).…”

Section: Pseudoexfoliation Syndrome As a Cause Of Glaucomasupporting

confidence: 79%

“…A positive relationship was observed between intraocular pressure and the degree of pigmentation of the drainage angle in XFS and possibly with the degree of trabecular dysfunction [29].…”

Section: Pseudoexfoliation Syndrome As a Cause Of Glaucomamentioning

confidence: 84%

“…The more frequent progression observed in XFG is due to higher mean IOP values, larger IOP spikes during the day than in POAG, older patient age, and greater visual field damage at diagnosis [28][29][30][31][32][33].…”

Section: Pseudoexfoliation Syndrome As a Cause Of Glaucomamentioning

confidence: 99%

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Pseudoexfoliation Syndrome—Clinical Characteristics of Most Common Cause of Secondary Glaucoma

Tomczyk-Socha,

Tomczak,

Winkler-Lach

et al. 2023

JCM

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Pseudoexfoliation syndrome (XFS) is a condition in which excess material builds up not only in the structures of the anterior chamber but also throughout the body. The frequency of the syndrome varies significantly (0.3–18%) depending on the region and the method of examination. Environmental risk factors for XFS include a large number of sunny days, proximity to the equator, dietary factors such as higher consumption of coffee and tea, long-term alcohol consumption, exposure to UV, and outdoor work. The pathognomonic sign of XFS is the presence of white material on the lens capsule and other anterior chamber components. In addition, a characteristic Sampaolesi line can be observed during gonioscopy. Systemic alterations indicative of XFS have been observed in the extracellular matrix of the eyelid skin, the heart, lungs, liver, kidneys, gallbladder, meninges, and endothelium of the blood vessels. XFS is the most common cause of secondary open-angle glaucoma, which is called pseudoexfoliative glaucoma and is more severe than primary open-angle glaucoma. It is plausible that a combination of environmental factors and genetic alterations promotes the onset of pseudoexfoliation syndrome, which requires additional research.

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Section: Pseudoexfoliation Syndrome As a Cause Of Glaucomasupporting

confidence: 79%

“…A positive relationship was observed between intraocular pressure and the degree of pigmentation of the drainage angle in XFS and possibly with the degree of trabecular dysfunction [29].…”

Section: Pseudoexfoliation Syndrome As a Cause Of Glaucomamentioning

confidence: 84%

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Pseudoexfoliation Syndrome—Clinical Characteristics of Most Common Cause of Secondary Glaucoma

Tomczyk-Socha,

Tomczak,

Winkler-Lach

et al. 2023

JCM

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“…• Remains the gold standard, rather than anterior eye imaging 33,34 • Important for identifying angle closure, which may be underdiagnosed or misdiagnosed as open-angle glaucoma 35,36 • Important for identifying and prognosticating secondary causes of open-angle glaucoma (pseudoexfoliation, 37,38 angle recession, 39,40 pigmentary [41][42][43] • Important for determining suitability for laser trabeculoplasty or the need for angle closure interventions (iridotomy, lens extraction) 44 Visual field…”

Section: Gonioscopymentioning

confidence: 99%

Management of open‐angle glaucoma by primary eye‐care practitioners: toward a personalised medicine approach

Phu

Agar

Wang

et al. 2021

Clinical and Experimental Optometry

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Glaucoma is the leading cause of irreversible blindness worldwide. As a chronic disease, glaucoma presents a significant burden to the individual, health-care provider and the health-care system. Currently, strategies for treating glaucoma are focused on lowering intraocular pressure, which is aimed at slowing or arresting disease progression over time. This is the only current accepted therapeutic strategy for glaucoma, and can be achieved using topical drugs, laser trabeculoplasty, filtration surgery or cyclodestructive techniques. The lowering of intraocular pressure has been wellsupported by numerous large-scale seminal clinical trials in primary open-angle glaucoma, in both its early and advanced stages. Although such guidance remains current, in the last 10-years, there has been a significant evolution in preferred first-line therapies in the treatment of open-angle glaucoma with a resultant shift in practice patterns, particularly early in the course of the disease. These changes reflect both from the perspective of the doctor -in titrating the most effective and least risky treatment modality -and the perspective of the patient, in consenting to a treatment that preserves vision and results in minimal negative impact on quality of life. In this review, the most recent evidence regarding treatment modalities for early primary open-angle glaucoma is presented and an updated framework for management guidance is proposed.

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Glaucoma

Yanoff¹,

Sassani²

2020

Ocular Pathology

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Evaluation of the anterior chamber angle in pseudoexfoliation syndrome

Abstract: Background. Pseudoexfoliation syndrome (PEX) is the most frequently identifiable cause of secondary open-angle glaucoma, known as pseudoexfoliation glaucoma. The exact pathophysiology and etiology of PEX and associated glaucoma remains obscure.

Cited by 5 publications

References 25 publications

Pseudoexfoliation Syndrome—Clinical Characteristics of Most Common Cause of Secondary Glaucoma

Pseudoexfoliation Syndrome—Clinical Characteristics of Most Common Cause of Secondary Glaucoma

Management of open‐angle glaucoma by primary eye‐care practitioners: toward a personalised medicine approach

Glaucoma

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