Ho Chi Minh City is changing and expanding quickly, leading to environmental consequences that seriously threaten human health. PM 2.5 pollution is one of the main causes of premature death. In this context, studies have evaluated strategies to control and reduce air pollution; such pollution-control measures need to be economically justi ed. The objective of this study was to assess the socioeconomic damage caused by exposure to the current pollution scenario, taking 2019 as the base year. A methodology for calculating and evaluating the economic and environmental bene ts of air pollution reduction was implemented. This study aimed to simultaneously evaluate the impacts of both short-term (acute) and long-term (chronic) PM 2.5 pollution exposure on human health, providing a comprehensive overview of economic losses attributable to such pollution. Spatial partitioning (inner-city and suburban) on health risks of PM 2.5 and detailed construction of health impact maps by age group and sex on a spatial resolution grid (3.0 km × 3.0 km) was performed. The calculation results show that the economic loss from premature deaths due to short-term exposure (approximately 38.86 trillion VND) is higher than that from long-term exposure (approximately 14.89 trillion VND). As the government of HCMC has been developing control and mitigation solutions for the Air Quality Action Plan towards short-and mediumterm goals in 2030, focusing mainly on PM 2.5 , the results of this study will help policymakers develop a roadmap to reduce the impact of PM 2.5 during 2025-2030.