Evaluation of the analgesic efficacies of Dexketoprofen Trometamol and Dexketoprofen Trometamol + Thiocolchicoside combinations in the impacted third molar surgery: Randomised clinical trial

Abstract

BackgroundPostoperative pain is one of the most common complications. The aim of this study is to evaluate the analgesic efficacies of dexketoprofen trometamol and two different dosages of dexketoprofen trometamol + thiocolchicoside combination in the impacted third molar tooth operation.Material and MethodsThis randomized, double-blind study included 75 patients who did not have any disease. Patients were assigned to 3 groups. Group 1 received 25 mg dexketoprofen trometamol + 4 mg thiocholchicoside, Group 2 received 25 mg dexketoprofen trometamol +8 mg thiocholchicoside, and Group 3 received 25 mg dexketoprofen trometamol. In each group, the analgesic medication was administered twice a day, starting 1 hour before the operation. The level of pain was assessed with VAS.ResultsPatient age varied from 18 to 36 years. Of all patients, 59.2% (n=42) were female and 40.8% (n=29) were male. Drug side effects were observed in 28.17% (n=20) of the patients. Mean 24th hour VAS score was lower in dexketoprofen trometamol + 8 mg thiocolchicoside group compared to dexketoprofen trometamol group (p<0.05). There was no statistically significant difference between the three groups regarding drug side effects (p>0.05).ConclusionsDexketoprofen trometamol + 8 mg thiocolchicoside combination has higher analgesic efficacy compared to dexketoprofen trometamol. More studies are needed to interpret the analgesic and anti-inflammatory effects of thiocholchicoside + dexketoprofen trometamol combination. Key words:Analgesic, dexketoprofen trometamol, thiocolchicoside, third molar surgery.

New Studies on Dexketoprofen

“…Cigerim L. and Kaplan V. conducted a randomized, double-blind clinical trial in which they assessed the efficacy of DEX and DEX in combination therapy with thiocolchicoside in two different proportional combinations in the treatment of pain after extraction of an impacted third molar [31].…”

Postoperative pain, edema and trismus following third molar surgery – A comparitive study between submucosal and intravenous dexamethasone

“…[ 6 ] Pain pathway is relayed through dorsal horn neurons in the spinal cord, which relay to the higher centers where the pain is assimilated. [ 7 ] As the inflammation progress the intestitial fluid accumulation due to transudation from injured blood vessels and obstruction of lymphatic drainage by fibrin and fibrinogen clots derived from plasma and adjacent injured vessels leads to postoperative edema. Facial edema is difficult to quantify accurately because it involves 3 dimensions of measurement with an irregular, convex surface and can manifest itself internally as well as externally.…”

Efficacy of Different Drugs for Migraine Treatment

“…The force of agony is diminished by increasing the dexketoprofen trometamol and dexketoprofen trometamol + 4 mg in thiocolchicoside bunches for 3 days, and in the dexketoprofen trometamol + 8 mg thiocolchicoside bunch for as long as 24 hours. Dexketroprofen + 8 mg in the thiocalcicoside bunch started to diminish torment levels contrasted and the other two gatherings, as the impact was progressively articulated in the wake of taking the subsequent portion [4]. At long last, dexactoprofen gives a pain relieving adequacy like COX-2 inhibitors when trometamol is utilized to treat intense torment, when begun early, is very much endured, and when utilized as a major aspect of a multimodal routine, Serious agony implantation [5].…”