Evaluation of the analgesic effects of capsaicin using a new rat model for tonic pain

Otsuki, Taisuke; Nakahama, Hiroshi; Niizuma, H; Suzuki, Jirô

doi:10.1016/0006-8993(86)91634-3

Cited by 49 publications

(30 citation statements)

References 31 publications

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“…A number of animal models of chronic pain have been developed to test and compare different types of drugs and to help better understand their mechanism of action and determine the involvement of a specific neurotransmitter. In some animal models central sensitization is produced by the injection of drugs, such as formalin, which induces spontaneous pain, or capsaicin which leads to hyperalgesia and/or allodynia (Otsuki et al, 1986). Other models use nerve injury to induce hyperalgesia and allodynia, which result in behavioural signs in rodents which are similar to the symptoms of neuropathic pain in humans.…”

Section: Introductionmentioning

confidence: 98%

Serotonin and noradrenaline reuptake inhibitors in animal models of pain

Mochizucki

2004

Hum. Psychopharmacol. Clin. Exp.

117

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Animal models of chronic pain serve as an experimental basis for testing new therapeutic interventions and for mechanistic investigations. In an animal model of chronic pain, based on the injection of formalin into the paw of a rodent, inhibitors of noradrenaline reuptake such as nisoxetine, nortriptyline and maprotiline and dual inhibitors of the noradrenaline and serotonin reuptake such as imipramine and milnacipran produce potent anti-nociceptive effects, whereas selective serotonin reuptake inhibitors, such as fluvoxamine, are much less potent. In another model, neuropathic pain resulting from the chronic constriction injury of the sciatic nerve was prevented by the dual uptake inhibitor, venlafaxine. The experimental model involving ligation of the 5th spinal nerve induces behavioural signs in rats and mice that are similar to the symptoms of human neuropathic pain. In this model amitriptyline, a non-selective serotonin and noradrenaline reuptake blocker, the preferential noradrenaline reuptake inhibitor, desipramine and the selective serotonin and noradrenaline reuptake inhibitors, milnacipran and duloxetine, produce a decrease in pain sensitivity whereas the selective serotonin reuptake inhibitor, fluoxetine, is ineffective. Antidepressants acting on the noradrenergic or both the noradrenergic and serotonergic systems thus appear to be more effective than those working on the serotonin system alone.

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Section: Introductionmentioning

confidence: 98%

Serotonin and noradrenaline reuptake inhibitors in animal models of pain

Mochizucki

2004

Hum. Psychopharmacol. Clin. Exp.

117

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“…Closely related are the weeks-long, chronic inflammatory pain models that use the intracapsular administration of urate crystals, Freund's adjuvant, capsaicin, or carrageenin [72][73][74]. Such long-term tonic pain in rats has been used to model human arthritis and to examine the safety and efficacy of various nonsteroid anti-inflammatory drugs (NSAIDs) [75], including the COX-1 and COX-2 inhibitors commonly used by patients for inflammatory pain [76].…”

Section: Long-duration Stimuli Tests (Tonic Pain)mentioning

confidence: 99%

Common animal models for spasticity and pain

Eaton¹

2003

JRRD

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Abstract-Animal models of spasticity and pain have allowed for the elucidation of possible mechanisms and the evaluation of potential therapeutic interventions for these serious clinical problems. Each model mirrors the clinical appearance of many features of the syndrome, but few reproduce the myriad patient reports of either intensity or relevant contributing factors, especially in models of chronic neuropathic pain. Often these models have been used to predict the potency and efficacy of pharmacologic agents that work in human pain states. Pain models have relied on measurements of the shifts in behavioral hypersensitivity to tactile and thermal stimuli, tests that are not used quantitatively in human patients. Even with the multiple peripheral and central models of spasticity and pain used in animals, only a few actually test human conditions: namely, diabetic neuropathy, chemotherapy, and immunotherapy for tumors. However, all these models have allowed for the comparison of certain behavioral, cellular, biochemical, and molecular mechanisms with human patient populations. Here we review the few extant models of spasticity, nerve injury, and central injury models of pain, and describe their features and use.

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“…It might also be possible to obtain the selectivity for pain conducting fibers, such as observed in intraneural administration of capsaicin [4], by con trolling the dose of ADR injected. Since adriamycin ganglionectomy is a less invasive and highly selective pain treatment, it may possibly be come an alternative for surgical ganglionectomy or rhizotomy.…”

Section: Discussionmentioning

confidence: 99%

Retrograde Adriamycin Sensory Ganglionectomy: Novel Approach for the Treatment of Intractable Pain

Kato¹,

Otsuki²,

Yamamoto

et al. 1990

Stereotact Funct Neurosurg

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Selective sensory ganglionectomy by means of retrograde suicide transport of adriamycin was performed on 3 patients with neuropathie pain in the areas of the trigeminal and intercostal nerves, producing significant pain relief, particularly from hyperalgesic pain. Adriamycin ganglionectomy is considered as a less invasive and highly selective pain treatment, which may possibly become an alternative for surgical ganglionectomy or rhizotomy.

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Evaluation of the analgesic effects of capsaicin using a new rat model for tonic pain

Cited by 49 publications

References 31 publications

Serotonin and noradrenaline reuptake inhibitors in animal models of pain

Serotonin and noradrenaline reuptake inhibitors in animal models of pain

Common animal models for spasticity and pain

Retrograde Adriamycin Sensory Ganglionectomy: Novel Approach for the Treatment of Intractable Pain

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