Evaluation of The Analgesic and Anti-Inflammatory Activity of The Aqueous Extract of Anvillea radiata from South West Algeria

Abstract

Anvillea radiata is used in traditional medicine for the treatment of chest colds, indigestion, and gastrointestinal disorders. Our plant has hypoglycaemic, antitumor, anti-inflammatory, and antibacterial activity and is used for the treatment of dysentery.We have investigated the analgesic and anti-inflammatory activity of the aqueous extract of Anvillea radiata. In analgesic activity, we have used mice of the strain NMRI Albinos, weighing between 26 and 38 g (in vivo study). Acetic acid was used to induce writhes in mice, and the evaluation of the analgesic activity shows that the aqueous extract at 150 mg/kg of our plant induces a decrease in the number of abdominal cramps caused by 1% acetic acid. The aqueous extract of our plant has an analgesic effect almost equal to that of Diclofenac; in fact, the latter causes a pain inhibition of 30.28 1.1% and that of Anvillea radiata of 28.71 2.1% for a concentration of 150 mg/ kg. Our results of this research indicated that Anvillea radiata inhibited inflammation, which could explain its use in traditional medicine.