2020
DOI: 10.1016/j.lfs.2020.118066
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Evaluation of the ameliorative effects of oral administration of metformin on epileptogenesis in the temporal lobe epilepsy model in rats

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Cited by 17 publications
(4 citation statements)
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“…The sclerotic hippocampus has an abnormal neuronal activity initiation region, which spreads to the frontal cortex [21].Some projections from the ventral hippocampus and ventral cingulate to the NAcSh, while efferent fibers mainly project to the VTA and frontal cortex [22,23]. Stereotactic ablations of the NAcSh have been applied to treat drug addiction, and refractory psychiatric disorders have also been identified as effective targets [24,25].When treatment of drug refractory epilepsy (DRE) with neuropsychological disorders, seizures were significantly alleviated [6,26]. In some studies, in which the NAc was electrically stimulated in a rat model combined with pilocarpine to initiate seizures, highfrequency stimulation of the NAc significantly prolonged the incubation period of seizures and inhibited their severity [13,27].…”
Section: Discussionmentioning
confidence: 99%
“…The sclerotic hippocampus has an abnormal neuronal activity initiation region, which spreads to the frontal cortex [21].Some projections from the ventral hippocampus and ventral cingulate to the NAcSh, while efferent fibers mainly project to the VTA and frontal cortex [22,23]. Stereotactic ablations of the NAcSh have been applied to treat drug addiction, and refractory psychiatric disorders have also been identified as effective targets [24,25].When treatment of drug refractory epilepsy (DRE) with neuropsychological disorders, seizures were significantly alleviated [6,26]. In some studies, in which the NAc was electrically stimulated in a rat model combined with pilocarpine to initiate seizures, highfrequency stimulation of the NAc significantly prolonged the incubation period of seizures and inhibited their severity [13,27].…”
Section: Discussionmentioning
confidence: 99%
“…Mossy fiber sprouting is considered a major feature of aberrant tissue remodeling after neural loss caused by epilepsy in both humans and animal models [ 23 , 24 ]. Recent studies also suggest that reduced mossy fiber sprouting is a potential mechanism of action of several anti-epilepsy therapies, which may reduce hippocampal neuronal injury [ 25 27 ]. Importantly, we found new evidence for a lower Timm score in NBP-treated epilepsy rats, which is likely associated with the reduced frequency of seizure onset.…”
Section: Discussionmentioning
confidence: 99%
“…AMPK activation by metformin also exhibits an anti-inflammatory effect in kainateinduced status epilepticus by inhibiting IL-1beta production and reducing the expression of glial fibrillary acidic protein (GFAP) and S100beta markers of astrogliosis, as well as by increasing secretion of the anti-inflammatory cytokine IL-10 [71]. In this model, metformin exerted a neuroprotective role against the kainate-induced epileptogenic process by preventing neuronal cell death, aberrant neurogenesis, and mossy fiber sprouting [72].…”
Section: Epilepsymentioning
confidence: 93%