Evaluation of the agreement between a point‐of‐care lactate meter and a handheld laboratory analyzer in cats treated in emergency practice

Acierno, Mark J.; Dedeaux, Andrea

doi:10.1111/vec.12911

Cited by 1 publication

(2 citation statements)

References 19 publications

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“…Currently, no studies have validated the HHLM for whole canine blood as used in this study, though good analytic performance has been shown when used for the analysis of canine plasma 6 and feline 7 whole blood. The method comparison and precision studies performed on the HHLM indicated adequate analytical performance of this machine in measuring lactate concentrations in canine whole blood samples (bias 0.26, CV 5.39%).…”

Section: Discussionmentioning

confidence: 99%

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Effect of time until sample analysis on lactate in dogs with shock

Rizzo

Rozanski

deLaforcade

2020

Veterinary Clinical Pathol

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IntroductionLactate concentrations can increase with hypoperfusion in dogs and could be used as a prognostic indicator in sick dogs. In a busy emergency service, sample evaluation could be delayed. However, sample evaluation delays have been shown to cause lactate concentration increases in healthy dogs. In sick dogs, the magnitude of increased lactate is unknown. The goal of this study was to prospectively evaluate the effect of room temperature storage times on lactate measurements in dogs presenting to an emergency service.MethodsWe evaluated the precision and accuracy of the NOVA Lactate Plus, using standard procedures. To assess the impact of time on lactate concentrations in sick dogs, we prospectively enrolled dogs presenting to an emergency service. Lactate concentrations were measured at six time points using samples stored at room temperature. A Friedman test, followed by a Wilcoxon rank test with a Bonferroni correction was used to evaluate time points.ResultsForty‐five dogs were enrolled in this prospective observational study. The Lactate Plus and table‐top analyzer compared favorably, with an R2 of .98, and a mean bias of 0.26 in 50 canine samples. Precision was acceptable, with a percent coefficient of variation of 5.39. Statistically significant increases in lactate concentrations were found at all time points over baseline (P = .008).ConclusionsIn as little as 7.5 minutes, lactate concentrations increased significantly in samples stored at room temperature. Dogs with lower initial lactate concentrations had had higher increases in lactate concentration percentages over 90 minutes.

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Section: Discussionmentioning

confidence: 99%

“…Agreement between the HHLM and the TTA was determined using the Bland‐Altman method, similar to the process used in a study performed by Acierno et al in 2019 7 . Statistical analyses were performed using STATA 14.2 software for MAC (StataCorp).…”

Section: Methodsmentioning

confidence: 99%