Evaluation of the acute toxicity of ellagic acid and gallic acid incorporated in Poloxamer407® gel, in Zophobas morio larvae

Campelo, Jamilly Erica Sousa; Nascimento, Matheus Oliveira do; Carvalho, André Luis Menezes; Santos, Hayana Sara Pereira; Almeida, José Otavio Carvalho Sena de; Alves, Michel Mualem de Moraes; Arcanjo, Daniel Dias Rufino; Tavares Neto, José Moreira; Muratori, Maria Christina Sanches; Costa, Amilton Paulo Raposo

doi:10.1016/j.tiv.2023.105727

Toxicology in Vitro

2024

DOI: 10.1016/j.tiv.2023.105727

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Evaluation of the acute toxicity of ellagic acid and gallic acid incorporated in Poloxamer407® gel, in Zophobas morio larvae

Jamilly Erica Sousa Campelo,

Matheus Oliveira do Nascimento,

André Luis Menezes Carvalho

et al.

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Cited by 2 publications

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Anti‐Inflammatory Activity and Acute Toxicity Of Pereskia aculeata, In Zophobas morio Larvae

e Silva,

Nunes,

Prado da Silva

et al. 2024

Chemistry & Biodiversity

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Pereskia aculeata has been widely investigated due to its anti‐inflammatory potential. Among the metabolites found in this species are the phytosterols beta‐sitosterol (β‐SIT) and stigmasterol (STIG). The objective of the study was to evaluate the anti‐inflammatory and toxicity activities of the hexane partition of P. aculeata (PHEX), as well as β‐SIT and STIG. PHEX was prepared and the phytosterols were quantified. In terms of toxicity against L929 fibroblast cells, PHEX showed toxicity up to 200 µg/mL; STIG and β‐SIT showed toxicity up to 25 µg/mL. PHEX inhibited 66% of nitric oxide radicals, while STIG and β‐SIT inhibited 33.73% and 34.94%, respectively. In an anti‐inflammatory test against Zophobas morio larvae, all samples significantly reduced hemocyte levels. Additionally, the LD50 values were calculated: 229.6 mg/kg for PHEX, 101.5 mg/kg for STIG, and 103.8 mg/kg for β‐SIT. In conclusion, the study indicates that the phytosterols present in PHEX may contribute to its anti‐inflammatory activity.

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Anti‐Inflammatory Activity and Acute Toxicity Of Pereskia aculeata, In Zophobas morio Larvae

e Silva,

Nunes,

Prado da Silva

et al. 2024

Chemistry & Biodiversity

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Gallic acid: A promising bioactive agent for food preservation and sustainable packaging development

Rahmawati,

Pratama,

Pratama

et al. 2024

Case Studies in Chemical and Environmental Engineering

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Evaluation of the acute toxicity of ellagic acid and gallic acid incorporated in Poloxamer407® gel, in Zophobas morio larvae

Cited by 2 publications

References 18 publications

Anti‐Inflammatory Activity and Acute Toxicity Of Pereskia aculeata, In Zophobas morio Larvae

Anti‐Inflammatory Activity and Acute Toxicity Of Pereskia aculeata, In Zophobas morio Larvae

Gallic acid: A promising bioactive agent for food preservation and sustainable packaging development

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