Evaluation of the activity of Tontelea micrantha extracts against bacteria, Candida and Mayaro virus

Abstract

The use of antimicrobials represents one of the most successful ways of chemotherapy in the medical clinic. These drugs were responsible for the control of several infectious diseases, which have been considered as the main cause of mortality and morbidity throughout the history of the humanity. [1] However, infectious diseases remain a major challenge to human health. Currently, it is estimated that about 1 billion people are diagnosed with mycoses annually, and more than 1.5 million die from complications of invasive fungal diseases. [2] Furthermore, infectious diarrhea and pneumonia account for 40% of child deaths worldwide, especially in underdeveloped regions. [3] Over the past 40 years, only two classes of antibiotics effective against Gram-negative bacteria have been approved for clinical use (e.g., oxazolidinones and cyclic lipopeptides) and the development of new antimicrobials in the future seems unpromising. [3] Currently, there is a scarce therapeutic arsenal for the treatment of fungal infections and the development of new antifungal drugs conflicts with the difficulty of finding compounds which are specific for fungal cells. [4] Similar situation happens with the development of new antivirals. Since viruses are obligate intracellular parasites, finding a drug that has an action against the virus but does not interfere with the basal functions of the cells is pointed out as the main challenge. [5] In this regard, considering the 15 largest companies in the pharmaceutical industry, only 5 of their drugs in the clinical or preclinical research phase are anti-infective agents. [3] The alarming increase in the microorganism's resistance to the currently available antimicrobials, caused mainly by the long-term exposure to subinhibitory concentrations of these

Investigation of studies involving the prospection of chemical compounds with antioxidant and antimicrobial potential from maytenus guianensis Klotzsch Ex Reissek in the north region: a brief review

“…Os membros desta família são conhecidos por apresentar compostos químicos com diversas atividades biológicas tais como, atividade analgésica, anti-inflamatória, antitumoral, antimicrobiana, antioxidante, anticolinesterásica, dentre outras (CLARICE et al, 2014;MENEZES, et al, 2014;RODRIGUES et al, 2019;CRUZ, et al, 2018;MAGALHÃES et al, 2011;FERREIRA et al, 2018;FERREIRA, et al, 2017;CAMARGO, 2022).…”