Evaluation of the accuracy of frozen section in different anatomical sites

Santana, Rafael P.; Morais, Nivaldo S.; Samary, Yves Renan S.; Bezerra, Artur Lício Rocha; Takano, Daniela Mayumi

doi:10.5935/1676-2444.20180053

Cited by 5 publications

(6 citation statements)

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“…In our current research, we observed complete agreement (100% concordance) without any disagreement in the frozen section analysis, mirroring Santana et al's study [ 29 ] where they reported a 99% concordance rate and only 1% disagreement among 101 breast specimens.…”

Section: Discussionsupporting

confidence: 89%

Diagnostic Utility of Fine-Needle Aspiration Cytology (FNAC) and Frozen Section Against Histopathology in Evaluating Benign and Malignant Breast Lesions

Sharma,

Ojha,

2024

Cureus

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Introduction: Breast lesions, particularly lumps, pose concerns for females, varying between benign and malignant conditions. Accurate differentiation solely through clinical assessment is challenging, necessitating a definitive diagnostic strategy. Fine-needle aspiration cytology (FNAC) is integral in the "triple approach" to breast evaluation, offering simplicity, reliability, and cost-effectiveness. However, FNAC has limitations, occasionally failing to yield definitive diagnoses due to inherent constraints. Contrarily, frozen-section analysis, a long-standing intraoperative diagnostic method, plays a crucial role in swift diagnosis during surgeries. Despite technological advancements, frozen sections serve specific diagnostic purposes, confirming carcinoma when FNAC is inconclusive and evaluating resected margins. However, freezing artifacts may affect tissue assessment, emphasizing the continued reliance on histopathology for guiding treatment decisions. Objectives: This study was conducted at KVG Medical College and Hospital, Sullia, Karnataka, India. It aimed to analyze the morphological characteristics of benign and malignant breast lesions using FNAC, frozen section, and histopathology and evaluate the sensitivity, specificity, and predictive values of FNAC and frozen section against histopathology as the reference standard. Methods: A cross-sectional investigation was carried out at a tertiary care hospital's Department of Pathology, on 60 female patients who presented with palpable breast masses over a span of two and a half years. FNAC was conducted, and the observations were classified into five categories as per the International Academy of Cytology guidelines. In addition, intraoperative frozen-section analysis was undertaken. A comparative analysis was conducted between the FNAC and intraoperative frozen-section findings, juxtaposed with the subsequent histopathological diagnoses. Results: FNAC revealed 51.7% malignant, 45% benign, and 3.3% inadequate cases; the frozen-section analysis indicated 51.6% malignant, 45% benign, and 3.3% deferred cases; histopathology showed 53.3% malignant, 45% benign, and 1.6% borderline cases. FNAC demonstrated 93.9% sensitivity, 100% specificity, 100% positive predictive value (PPV), 93.1% negative predictive value (NPV), and 96.7% accuracy. The frozen-section analysis exhibited 96.9% sensitivity, 100% specificity, 100% PPV, 96.4% NPV, and 98.3% accuracy. Conclusion: Intraoperative frozen-section analysis displays superior diagnostic utility compared to preoperative FNAC. However, histopathology remains the definitive gold standard. Integrating all three diagnostic modalities is crucial for precise diagnosis and effective patient management.

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Section: Discussionsupporting

confidence: 89%

Diagnostic Utility of Fine-Needle Aspiration Cytology (FNAC) and Frozen Section Against Histopathology in Evaluating Benign and Malignant Breast Lesions

Sharma,

Ojha,

2024

Cureus

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“…In these studies, R0 based on frozen section analysis was used for decision-making. However, frozen sections can provide false negative diagnosis and are time-consuming [33,34]. In the current study, we sampled for frozen sections in 36.1% of cases and reached a low sensitivity of 61.1%.…”

Section: Discussionmentioning

confidence: 84%

Clinical selection strategy for and evaluation of intra-operative brachytherapy in patients with locally advanced and recurrent rectal cancer

Dijkstra

Mul

Hemmer

et al. 2021

Radiotherapy and Oncology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Em relação aos resultados discordantes, os números encontrados evidenciaram 3,88% do total de casos, uma taxa dentro do esperado, visto que foi notada uma variação entre 2,00% a 6,18% em outras investigações [2][3][4][5][6][7]13,17 . Esses resultados foram compostos em sua maior parte por diagnósticos falso negativos (02,01%) que falso positivos (01,87%), assim como o constatado por Silva RDP et al 2 e Hatami H et al 5 .…”

Section: Discussionunclassified

A Acurácia Diagnóstica Das Patologias Cirúrgicas Nos Exames Por Congelação.

Silva

Panjwani

Barbosa

et al. 2023

Braz. J. Implantol. Health Sci.

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Introdução: O exame por congelação é uma forma rápida de avaliação histopatológica de fragmentos teciduais durante o intra-operatório, tratando-se de uma importante ferramenta no auxílio ao cirurgião à tomada de decisão. Objetivo: Aferir a acurácia diagnóstica dos exames por congelação em diferentes sítios anatômicos efetuados no serviço de patologia de um hospital universitário. Material e métodos: Estudo de natureza exploratória, com abordagem quantitativa do tipo documental. A amostra compreende 803 laudos médicos dos exames de congelação e os definitivos em parafina no período de primeiro de janeiro de 2015 a primeiro de janeiro de 2020, disponíveis no Laboratório de Anatomia Patológica do Hospital Universitário Professor Alberto Antunes (HUPAA), sendo excluídos 106 laudos com dados que estiveram indisponíveis por qualquer motivo. Resultados: Observou-se que, das 697 peças cirúrgicas que compõem esta pesquisa, 540 (77,47%) tiveram como indicação o diagnóstico da lesão e 157 (22,53%) a avaliação de margens. Os sítios anatômicos mais analisados foram a mama em 177 casos, linfonodo em 120 e pele em 106 casos. Em relação ao maior número de resultados discordantes, de modo global, a mama vem em primeiro lugar com 08 casos, seguida de ovário e anexos com 05 casos e, em relação aos sítios específicos, o peritônio apresentou 10,00% dos seus casos, enquanto que ovário e anexos 08,47%. Os exames anatomopatológicos por congelação apresentaram uma taxa referente a acurácia total de 91,10%, tendo a mama, de forma específica, 94,93%, intra-abdominal 93,75% e linfonodo 93,33%. Conclusão: É alta a taxa de acurácia observada e os números estão em consonância com diversos estudos similares, o que reforça a importância do exame e a qualidade dos procedimentos realizados pelo serviço em questão.

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Evaluation of the accuracy of frozen section in different anatomical sites

Cited by 5 publications

References 0 publications

Diagnostic Utility of Fine-Needle Aspiration Cytology (FNAC) and Frozen Section Against Histopathology in Evaluating Benign and Malignant Breast Lesions

Diagnostic Utility of Fine-Needle Aspiration Cytology (FNAC) and Frozen Section Against Histopathology in Evaluating Benign and Malignant Breast Lesions

Clinical selection strategy for and evaluation of intra-operative brachytherapy in patients with locally advanced and recurrent rectal cancer

A Acurácia Diagnóstica Das Patologias Cirúrgicas Nos Exames Por Congelação.

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