Evaluation of the ability of orally administered aspirin to mitigate effects of 3-methylindole in feedlot cattle

Abstract

Cattle given a single orally administered dose of aspirin on feedlot entry had higher MDG in the backgrounding unit and for the overall feeding period, but this finding could not be attributed to mitigation of effects of 3MI. This may have been influenced by low peak 3MI production and slow rates of gain.

Feedlot Acute Interstitial Pneumonia

“…31,33 It has been claimed, however, that aspirin treatment of cattle with clinical signs of AIP is associated with longer survival. 34 Removal of MGA from the diets of heifers has been reported to decrease rates of AIP.…”

Time-dependent changes in plasma concentrations of 3-methylindole and blood concentrations of 3-methyleneindolenine-adduct in feedlot cattle

“…However, an association between serum 3MI concentration and MDG was not detected in another study. 37 We did not find a significant association between maximum plasma 3MI concentration on days 0 through 9 with MDG. However, maximum blood 3MEIN-adduct concentration from the same time period was associated with significant improvements in MDG.…”