Evaluation of the Ability of PAMPA Membranes to Emulate Biological Processes through the Abraham Solvation Parameter Model

Abstract

Two parallel artificial membrane permeability assay (PAMPA) systems intended for emulating skin permeability have been characterized through the solvation parameter model of Abraham using multilinear regression analysis. The coefficients of the obtained equations have been compared to the ones already established for other PAMPA membranes using statistical tools. The results indicate that both skin membranes are similar to each other in their physicochemical properties. However, they are different from other PAMPA membranes (e.g., intestinal absorption and blood–brain PAMPAs), mainly in terms of hydrophobicity and hydrogen bonding properties. Next, all PAMPA membranes have been compared to relevant biological processes also characterized through the solvation parameter model. The results highlight that skin-PAMPA membranes are a very good choice to emulate skin permeability.

Abraham Model Descriptors for Vitamin K4: Prediction of Solution, Biological and Thermodynamic Properties

“…We note that the Abraham model enables estimation of many other important pharmaceutical properties besides solubility. Expressions have been reported for human skin permeations from aqueous solutions [28,29], human and animal air-to-blood partition coefficients [30], air-to-lung and blood-to-lung partition coefficients [31], air-to-muscle and blood-to-muscle distribution coefficients [32], Draize rabbit eye test compatibility and eye irritation thresholds in humans [33], human intestinal absorption of neutral molecules and ionic species [34,35]; air-tofat and blood-to-fat distribution coefficients of drugs and volatile organic compounds [36], in vivo blood-to-rat brain distribution coefficients [37], in vitro air-to-rat/human brain partition coefficients of volatile organic compounds [38], solute permeabilities from select parallel artificial membrane permeability assay (PAMPA) models [39,40], and water-tomuscle protein partition coefficients [41,42]. The Abraham model correlations have also been used to assist researchers identify organic solvents that can mimic blood [43] and fatty tissue [44] for extraction and leaching studies to test the safety of medical devices that come into direct contact with a patient's body fluids and tissues.…”