Evaluation of the ability of paracetamol to produce chromosome aberrations in man

Hantson, P.; Saint-Georges, L. de; Mahieu, Paul; Léonard, Évelyne; Crutzen-Fayt, M.C.; Léonard, A.

doi:10.1016/s0165-1218(96)90071-3

Cited by 12 publications

(7 citation statements)

References 14 publications

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“…However, certain clastogenic potential was detected only in human lymphocyte cultures treated with 200 μg/mL of paracetamol. Clearly, our findings support those of Hantson et al (1996). The majority of aberrations found in our study were chromatid breaks.…”

Section: Resultssupporting

confidence: 88%

“…That could be connected to inhibition of DNA synthesis by paracetamol (Lister and McLean, 1997;Hongslo, 1990). On the other hand, despite decreased mitotic index, Hantson et al (1996) found no significant increase in chromosome aberrations in volunteers administered 3 g of paracetamol, in patients treated with intravenous infusion of a total of 28 g of paracetamol, as well as in self-poisoned patients who had ingested more than 15 g of paracetamol. In our in vitro study, the tested concentrations of paracetamol were quite higher than therapeutic.…”

Section: Resultsmentioning

confidence: 72%

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Cytogenetic Evaluation of Paracetamol Effects in Human Lymphocytes Culture

Ibrulj

Rahmanović

Haverić

et al. 2007

Drug and Chemical Toxicology

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Paracetamol is a common analgesic and antipyretic drug. It has been recognized as one of the most ordinary medications taken in overdoses. We examined the possible genotoxic effects of high paracetamol concentrations expected to occur after overdose. Paracetamol was added to the cultures at the beginning of the cultivation period. Separate cultures for three tested concentrations of paracetamol (50 microg/mL, 100 microg/mL, and 200 microg/mL) were set. Effects of paracetamol were evaluated by micronucleus cytokinesis-block assay, chromosome aberration analysis, and nuclear division index. Results demonstrate that paracetamol concentration of 200 microg/mL expresses certain genotoxic effects in human peripheral blood lymphocytes.

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Section: Resultssupporting

confidence: 88%

Section: Resultsmentioning

confidence: 72%

Cytogenetic Evaluation of Paracetamol Effects in Human Lymphocytes Culture

Ibrulj

Rahmanović

Haverić

et al. 2007

Drug and Chemical Toxicology

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“…Similar ndings have been reported by Aragon et al (2005). The mechanism for this type of defects could be the ability of vanadium to inhibit microtubule polymerization (Hantson et al, 1996;Ramirez et al, 1997) and induction of 2'deoxyguanosine hydroxylation and to cause DNA breaks by means of free radical mediated reactions as well as single-stranded breaks (Shi et al, 1996;Usende et al, 2018b). This is further explained by the increased expression of anti-P 53 immunostain observed in SMV treated group.…”

Section: Discussionsupporting

confidence: 63%

Reproductive Hormones Imbalance, Germ Cell Apoptosis, Abnormal Sperm Morphophenotypes and Ultrastructural Changes in Testis of African Giant Rats (Cricetomys gambianus, Waterhouse, 1840) Exposed to Sodium Metavanadate Intoxication

Usende

Oyelowo

Adikpe

et al. 2021

Preprint

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Environmental exposure to vanadium has been on the increase in recent time. This metal is a known toxicant. The current study was conducted to investigate the reproductive toxicity of sodium metavanadate (SMV) in male African giant rats. Administration of SMV was done intraperitoneally daily for 14 consecutive days at a dosage of 3mg/kg body weight. Sterile water was administered to the control group. We analyzed serum reproductive hormones, sperm reserve and quality as well as testicular ultrastructural changes following SMV treatment. Our results showed SMV exposed AGR group had statistically increased progesterone but decreased testosterone, FSH and LH concentrations. Also, SMV treated group had statistically decreased sperm motility and mass activity with increased percentage of abnormal morphophenotypes of spermatozoa and upregulation of P53 immunopositive cell. Ultrastructural study revealed vocuolation of germ and Sertoli cells, cytoplasmic and nucleus; and mitochondrial swelling and vacuolations were also observed. There was severe disintegration of the seminiferous tubules, atrophy and degeneration of myeloid cells and apoptosis of the Leydig, Sertoli and germ cells. In conclusion, intraperitoneal SMV exposure exerts severe adverse effects on some serum reproductive hormones, reduction of sperm reserve and quality, apoptosis and degenerative changes of the Leydig, Sertoli and germ cells which can lead to infertility.

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“…Treatment with megumine antimoniate for leishmaniasis caused a later increase in MN levels in blood cells, but no increases in chromosome aberrations [190].…”

Section: Antimonymentioning

confidence: 90%

Genetic Toxicology of Arsenic and Antimony

Rossman¹,

Klein²

2010

Biological Chemistry of Arsenic, Antimony and Bismuth

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Interest in the genetic toxicology of arsenic (As) is motivated by the fact that it is considered as a human carcinogen [1]. The genetic toxicology of arsenicals mainly pertains to that of the trivalent arsenical arsenite (As III ) (Chapter 8) and its trivalent monomethylated and dimethylated metabolites (MMA III and DMA III ) (Chapter 7). The corresponding pentavalent compounds are both less toxic and less genotoxic than the trivalent compounds. This is because the pentavalent compounds are less reactive than the trivalent compounds, which can enter cells more readily than the pentavlent compounds (Chapter 8). Once inside the cell, pentavalent compounds are immediately reduced to trivalent compounds, so the genetic toxicology is attributed to the trivalent species and their products. However, the thioarsenical metabolite dimethyldithioarsinic acid (DMDTA V ), which is pentavalent, shows cytotoxicity and genotoxicty that resembles DMA III rather than DMA V [2]. It must also be kept in mind that some cell lines are able to methylate arsenite. Although hepatocytes are not often used for assessing genotoxicity, rat hepatocytes have a higher rate of methylation than that of human hepatocytes [3]. Insignificant amounts or no methylation was seen in normal human keratinocytes [4], UROtsa cells (SV40-transformed human bladder epithelial line) [3], human lymphoblasts (M. Styblo, personal communication),

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Evaluation of the ability of paracetamol to produce chromosome aberrations in man

Cited by 12 publications

References 14 publications

Cytogenetic Evaluation of Paracetamol Effects in Human Lymphocytes Culture

Cytogenetic Evaluation of Paracetamol Effects in Human Lymphocytes Culture

Reproductive Hormones Imbalance, Germ Cell Apoptosis, Abnormal Sperm Morphophenotypes and Ultrastructural Changes in Testis of African Giant Rats (Cricetomys gambianus, Waterhouse, 1840) Exposed to Sodium Metavanadate Intoxication

Genetic Toxicology of Arsenic and Antimony

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