Evaluation of temporomandibular joint disc displacement as a risk factor for osteoarthrosis

Dias, Iêda Maria Ávila Vargas; Cordeiro, Patricia Cataldo de Felipe; Devito, Karina Lopes; Tavares, M L F; Leite, Isabel Cristina Gonçalves; Tesch, Ricardo de Souza

doi:10.1016/j.ijom.2015.09.016

Cited by 76 publications

(52 citation statements)

References 30 publications

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“…Temporomandibular joint osteoarthritis (TMJ‐OA) is one of the most common forms of temporomandibular disorder (TMD), which frequently associates with condylar erosion and flattening, disk perforation, pain during functional activities and TMJ palpation, joint sounds, mouth opening deviation, jaw hypomobility, and worsened mastication . Despite being defined as a local inflammatory disease, its development could be due to either local factors, including microtrauma or macrotrauma secondary to disk displacement, or systemic factors, including systemic inflammatory disorders such as rheumatoid arthritis, psoriatic arthritis or reactive arthritis . Actually, many factors have been proposed as responsible for the TMJ‐OA development, such as genetic factors, over‐loading, unilateral chewing, bruxism and internal derangements; however, the molecular basis of the TMJ‐OA aetiopathogenesis remains unclear …”

Section: Introductionmentioning

confidence: 99%

Th1/Th17/Th22 immune response and their association with joint pain, imagenological bone loss, RANKL expression and osteoclast activity in temporomandibular joint osteoarthritis: A preliminary report

Monasterio

Castillo

Rojas

et al. 2018

J of Oral Rehabilitation

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It is well accepted that the presence of cytokines belonging to the Th1/Th17/Th22 axis of immuno-inflammatory response in the joint environment, such as IL-1β, IL-17 and IL-22, respectively, are associated with pathogenesis of several synovial joint degenerative disorders. During temporomandibular joint osteoarthritis (TMJ-OA), IL-1β and IL-17 have been implicated in the inflammation and resorption of sub-chondral bone; however, the role of Th22 response in the TMJ-OA pathophysiology has not been established. This study aimed to compare the expression of Th1/Th17/Th22-type cytokines, chemokines and chemokine receptors in synovial fluid samples obtained from TMJ-OA or disk displacement with reduction (DDWR) patients. In addition, it aimed to associate these levels with joint pain, imagenological signs of bone degeneration, RANKL production, osteoclastogenesis and osteoclast-induced bone resorption. Higher levels of IL-1β, IL-17 and IL-22 were expressed in TMJ-OA compared with DDWR subjects, and these increased levels significantly correlated with RANKL expression, joint pain and articular bone degeneration. Higher levels of CCR5, CCR6 and CCR7, as well as their respective ligands CCL5 and CCL20, responsible for recruitment of IL-1β, IL-17 and IL-22-producing cells, were over-expressed in TMJ-OA compared with DDWR subjects. Osteoclastogenesis and osteoclast-induced bone resorption were significantly greater in presence of synovial fluid from TMJ-OA compared with DDWR subjects. These data demonstrate that cytokines, CCLs and CCRs associated with the Th1/Th17/Th22 axis of immuno-inflammatory response are involved in TMJ-OA pathogenesis. These findings suggest that IL-22 is involved in the RANKL expression in TMJ-OA, which in turn induces differentiation of osteoclasts and subsequent resorption of sub-chondral bone.

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Section: Introductionmentioning

confidence: 99%

Th1/Th17/Th22 immune response and their association with joint pain, imagenological bone loss, RANKL expression and osteoclast activity in temporomandibular joint osteoarthritis: A preliminary report

Monasterio

Castillo

Rojas

et al. 2018

J of Oral Rehabilitation

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“…Arthritis, ie articular tissue inflammation, in the temporomandibular joint (TMJ) is a disorder due to either local or systemic factors. Examples of local factors are micro‐ or macrotrauma secondary to disc displacement or degenerative joint disease and infection . Systemic factors may be systemic inflammatory disorders such as rheumatoid arthritis (RA), psoriatic arthritis (PsA) or reactive arthritis.…”

Section: Introductionmentioning

confidence: 99%

Clinical diagnosis of temporomandibular joint arthritis

Alstergren

Pigg

Kopp

2018

J of Oral Rehabilitation

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Evidence-based clinical diagnostic criteria for temporomandibular joint (TMJ) arthritis are not available. To establish (i) criteria for clinical diagnosis of TMJ arthritis and (ii) clinical variables useful to determine inflammatory activity in TMJ arthritis using synovial fluid levels of inflammatory mediators as the reference standard. A calibrated examiner assessed TMJ pain, function, noise and occlusal changes in 219 TMJs (141 patients, 15 healthy individuals). TMJ synovial fluid samples were obtained with a push-pull technique using the hydroxycobalamin method and analysed for TNF, TNFsRII, IL-1β, IL-1ra, IL-1sRII, IL-6 and serotonin. If any inflammatory mediator concentration exceeded normal, the TMJ was considered as arthritic. In the patient group, 71% of the joints were arthritic. Of those, 93% were painful. About 66% of the non-arthritic TMJs were painful to some degree. Intensity of TMJ resting pain and TMJ maximum opening pain, number of jaw movements causing TMJ pain and laterotrusive movement to the contralateral side significantly explained presence of arthritis (AUC 0.72, P < .001). Based on these findings, criteria for possible, probable and definite TMJ arthritis were determined. Arthritic TMJs with high inflammatory activity showed higher pain intensity on maximum mouth opening (P < .001) and higher number of painful mandibular movements (P = .004) than TMJs with low inflammatory activity. The combination TMJ pain on maximum mouth opening and Contralateral laterotrusion <8 mm appears to have diagnostic value for TMJ arthritis. Among arthritic TMJs, higher TMJ pain intensity on maximum mouth opening and number of mandibular movements causing TMJ pain indicates higher inflammatory activity.

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“…Do występujących symptomów można zaliczyć problemy kliniczne w mięśniach żucia, upośledzenie zakresu ruchu żuchwy oraz pojawiający się ból. [53][54][55][56] Schorzenie można diagnozować za pomocą CBCT, w obrazie którego występuje zazwyczaj erozja kości kłykcia, spłaszczenie i osteofity. 57 Badania dotyczące związku obecności wysięku stawowego u osób chorujących na zapalenie kości i stawów oraz ssż (diagnozowanych przy użyciu rezonansu magnetycznego) wraz z przemieszczeniem krążka stawowego bez zablokowania (PKBZ) wykazały, że w większości przypadków nie stwierdza się obecności wysięku stawowego.…”

Section: Choroba Zwyrodnieniowa Stawów (Ang Osteoarthritis -Oa)unclassified

Relationship of temporomandibular disorders with selected systemic diseases

Gruca¹,

Tysiąc-Miśta²,

Czelakowska³

et al. 2019

Prosthodontics

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Schorzenia skroniowo-żuchwowe (ang. temporomandibular disorders, TMD) są zespołem zaburzeń charakteryzujących się między innymi bólem mięśni w obrębie twarzy, głowy i szyi, bólami stawu skroniowo-żuchwowego (ssż), objawami akustycznymi czy też zaburzeniami toru oraz zakresu ruchów żuchwy. Zaburzenia w obrębie narządu żucia mogą w pewnym okresie życia dotyczyć nawet 50-75% populacji. Etiologia TMD nie jest do końca znana. Występowanie schorzeń jest zdeterminowane występowaniem wielu czynników, m.in. czynnikami wrodzonymi, zewnętrznymi, emocjami. Celem tego poglądowego artykułu jest zgłębienie informacji o TMD, jako schorzeniu pojawiającym się w przebiegu wielu chorób i zaburzeń stanu organizmu. Należy

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Evaluation of temporomandibular joint disc displacement as a risk factor for osteoarthrosis

Cited by 76 publications

References 30 publications

Th1/Th17/Th22 immune response and their association with joint pain, imagenological bone loss, RANKL expression and osteoclast activity in temporomandibular joint osteoarthritis: A preliminary report

Th1/Th17/Th22 immune response and their association with joint pain, imagenological bone loss, RANKL expression and osteoclast activity in temporomandibular joint osteoarthritis: A preliminary report

Clinical diagnosis of temporomandibular joint arthritis

Relationship of temporomandibular disorders with selected systemic diseases

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