Evaluation of Temperature-Responsive Open Tubular Capillary Electrochromatographic Column Modified with Poly(N-isopropylacrylamide)

Liu, Zongjian; Geng, Fang; Ha, Xuefeng; Feng, Yusi; Che, Baoquan; Wu, Kechun; Li, Yujuan; Dai, Rongji; Zhang, Yukui; Deng, Yulin

doi:10.1007/s10337-012-2383-5

Cited by 14 publications

(11 citation statements)

References 21 publications

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“…Nevertheless, it should be declared that all of the above-stated discussions are based on assumptions and further studies are required to approve them through the identification of the degradation products. As a final discussion it can be said that, in comparison with the previously reported CE-based methods for the analysis of OCT-Ac [13][14][15], the proposed method is easy to use; as well as, it could separate OCT-Ac and degradation products with no need to any sample pretreatment or any organic solvents. These advantages along with the stability-indicating capacity make the proposed method applicable as a simple SIM to quantify OCT-Ac in the force-degraded samples without any interference and to investigate its degradation kinetics in aqueous solutions under stress conditions.…”

Section: Analysis Of Pharmaceutical Formulations and Force-degraded Smentioning

confidence: 99%

“…In another work, Jaworska et al [14] used a two-dimensional HPLC-CE method for the separation and identification of some OCT-Ac-related impurities in a pharmaceutical dosage form and possible degradation products formed under elevated temperature (37 °C, 12 weeks). In a recent study, Liu et al [15] investigated a temperature-responsive CEC method for the separation of OCT-Ac and thymopentin mixture using poly(N-isopropylacrylamide)-grafted capillary columns for improving the separation efficacy of the method.…”

Section: Introductionmentioning

confidence: 99%

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A Simple Stability Indicating CZE Method for the Analysis of Octreotide Acetate

Tamizi

Jouyban

2014

Chromatographia

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Section: Analysis Of Pharmaceutical Formulations and Force-degraded Smentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Simple Stability Indicating CZE Method for the Analysis of Octreotide Acetate

Tamizi

Jouyban

2014

Chromatographia

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“…Other papers have described techniques to produce sol‐gel matrices or cyclodextrin (CD)‐based chiral SPs . The use of in situ reaction procedures with sequential introduction of reactants leading to poly‐( N ‐isopropylacrylamide) modified surfaces, which are temperature‐responsive, has been documented . Similarly, block polymer modified surfaces have also been described.…”

Section: Preparation Approaches For Ot‐cec Coatingsmentioning

confidence: 99%

“…Selectivity could be conveniently adjusted by changing the ratio of two kinds of nanoparticles (optimized at 2:1 ratio of Fe 3 O 4 @SiO 2 –NH 2 to Fe 3 O 4 @SiO 2 –C 18 ). Liu and coworkers have also separated peptide drugs using a temperature‐responsive poly( N ‐isopropylacrylamide) that exhibited hydrophilic interaction below its lower critical solution temperature (LCST) and hydrophobic behavior above its LCST .…”

Section: Modes Of Separationmentioning

confidence: 99%

Open tubular‐capillary electrochromatography: Developments and applications from 2013 to 2015

et al. 2016

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Open tubular CEC (OT-CEC) separates analyte mixtures by a combination of electrophoretic, electro-osmotic, and/or chromatographic effects. OT-CEC research is an active and growing field, with studies encompassing a wide range of investigations related to new strategies for chemical modification of the inner surface of the capillary, leading to the introduction of novel stationary phase coatings. This review has examined the literature on OT-CEC from 2013 to August 2015 and highlights the developments in the fabrication of highly selective stationary phases, based on materials that include cyclodextrin chiral selectors, graphene and graphene oxide, metal-organic frameworks, molecularly imprinted polymers, nanoparticles, nanolatex particles, nanocomposites, in situ generated polymers, block polymers, tentacle-type polymers, polyelectrolyte multilayers, polysaccharides, phospholipids, and proteins. This review, while considering the development of novel OT-CEC coating materials, specifically examines different immobilization or coating methodologies and approaches and also discusses the separation mechanisms that occur with these new materials. These OT-CEC coatings are intended mainly to separate low molecular weight molecules relevant to the pharmaceutical, agricultural, and food industries as well as for use in environmental monitoring.

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“…Open tubular mode of CEC (OT‐CEC) with the thin layer stationary phase covalently bound or physically adsorbed to the inner capillary wall is also applied to separation of peptides. Temperature responsive FS OT‐CEC column grafted with poly( N ‐isopropylacrylamide), the best known temperature‐responsive polymer with a relatively low critical solution temperature of 32°C in aqueous solution, proved to be a suitable tool for fast separation of clinical drugs including two peptides, thymopentin, and octreotide acetate .…”

Section: Separations In Different Ce and Cec Modesmentioning

confidence: 99%

Recent developments in capillary and microchip electroseparations of peptides (2013–middle 2015)

Kašička

2015

Electrophoresis

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The review brings a comprehensive survey of recent developments and applications of high performance capillary and microchip electroseparation methods (zone electrophoresis, isotachophoresis, isoelectric focusing, affinity electrophoresis, electrokinetic chromatography, and electrochromatography) to analysis, micropreparation, purification, and physicochemical and biochemical characterization of peptides in the years 2013, 2014, and ca. up to the middle of 2015. Advances in the investigation of electromigration properties of peptides, in the methodology of their analysis, including sample preseparation, preconcentration and derivatization, adsorption suppression and EOF control, as well as in detection of peptides, are described. New developments in particular CE and CEC modes are presented and several types of their applications to peptide analysis are reported: conventional qualitative and quantitative analysis, determination in complex (bio)matrices, monitoring of chemical and enzymatical reactions and physical changes, amino acid, sequence, and chiral analysis, and peptide mapping of proteins. Some micropreparative peptide separations are shown and capabilities of CE and CEC techniques to provide important physicochemical characteristics of peptides are demonstrated.

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Evaluation of Temperature-Responsive Open Tubular Capillary Electrochromatographic Column Modified with Poly(N-isopropylacrylamide)

Cited by 14 publications

References 21 publications

A Simple Stability Indicating CZE Method for the Analysis of Octreotide Acetate

A Simple Stability Indicating CZE Method for the Analysis of Octreotide Acetate

Open tubular‐capillary electrochromatography: Developments and applications from 2013 to 2015

Recent developments in capillary and microchip electroseparations of peptides (2013–middle 2015)

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