EVALUATION OF TECHNETIUM-99m-(Tc-99m)-LABELED LIPOSOMES VERSUS Tc-99m-SULFUR COLLOID (SC) AND Tc-99m-HUMAN SERUM ALBUMIN (HSA) FOR LYMPHOSCINTIGRAPHY IN A RABBIT MODEL.

Phillips, William T.; Andrews, Trevor; Liu, H. L.; Klipper, Robert; Landry, Al; Blumhardt, Ralph; Goins, Beth

doi:10.1097/00003072-199903000-00037

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A blue dye-encapsulated liposomes as a potential system could maintain blue staining in lymph nodes for more than a week after subcutaneous injection in living animals [ 106 ]. The team further prepared blue liposomes containing glutathione by combining 99m Tc with blue dye, which could be traced in both directions by lymphatic channels and radiation detection instruments, and used for lymphatic scintigraphy and intraoperative lymph node identification [ 107 ]. However, clinical trials of this system are essential to further demonstrate their efficacy.…”

Section: Nanoparticle For Lymph Node Specific Imaging and Identificationmentioning

confidence: 99%

Advances in nanomedicines for lymphatic imaging and therapy

He,

Tang,

Zheng

et al. 2023

J Nanobiotechnol

View full text Add to dashboard Cite

Lymph nodes play a pivotal role in tumor progression as key components of the lymphatic system. However, the unique physiological structure of lymph nodes has traditionally constrained the drug delivery efficiency. Excitingly, nanomedicines have shown tremendous advantages in lymph node-specific delivery, enabling distinct recognition and diagnosis of lymph nodes, and hence laying the foundation for efficient tumor therapies. In this review, we comprehensively discuss the key factors affecting the specific enrichment of nanomedicines in lymph nodes, and systematically summarize nanomedicines for precise lymph node drug delivery and therapeutic application, including the lymphatic diagnosis and treatment nanodrugs and lymph node specific imaging and identification system. Notably, we delve into the critical challenges and considerations currently facing lymphatic nanomedicines, and futher propose effective strategies to address these issues. This review encapsulates recent findings, clinical applications, and future prospects for designing effective nanocarriers for lymphatic system targeting, with potential implications for improving cancer treatment strategies.

show abstract

Section: Nanoparticle For Lymph Node Specific Imaging and Identificationmentioning

confidence: 99%