Evaluation of tauroursodeoxycholic acid in liver cells’ cultures by MEKC: Initial hints to comprehend its role in diabetes mellitus of obese individuals
Bruna Eduarda Santos Simões,
Mariana Roberta Rodrigues Muniz,
Thiago dosReis Araujo
et al.
Abstract:Genetic factors, diet, lifestyle, and other factors lead to various complications in the body, such as obesity and other chronic diseases. The inflammatory state caused by excessive accumulation of body fat affects the pathways related to the control of glycemic homeostasis, leading to a high demand for insulin, to subsequent failure of stressed β cells, and development of type 2 diabetes mellitus (T2DM). The study of new endocrine signalers, such as bile acids (BAs), becomes necessary as it allows the develop… Show more
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