Abstract:The aim of this study was to use 3D modeling to differentiate not only among the four different types of lactose alpha-lactose monohydrate, spray-dried lactose, agglomerated lactose and lactose anhydrous but also between products from different manufacturers. Further "box-counting" fractal analysis of SEM images was done to gain additional information on tableting characteristics and tablet properties which can be found in the fractal structure. Twelve different materials from different manufacturers were anal… Show more
“…The fractal dimension exhibited a major decrease in value during swelling and was highly correlated with the swelling ratio, thus indicating that the fractal dimension provided an interesting quantitative parameter related to surface roughness. For solid pharmaceutical dosage forms, D f values derived from surface imaging techniques have been employed to characterize the surface morphology of particles, mainly focusing on 2D static measurements, such as scanning electron microscopy and atomic force microscopy . Information on surface roughness and shape for particles and tablets has been gained from the values of fractal dimensions.…”
Section: Introductionmentioning
confidence: 99%
“…For solid pharmaceutical dosage forms, Df values derived from surface imaging techniques have been employed to characterize the surface morphology of particles, mainly focusing on 2D static measurements, such as scanning electron microscopy and atomic force microscopy. [16][17][18][19] Information on surface roughness and shape for particles and tablets has been gained from the values of fractal dimensions. However, there are few publications focusing on fractal analysis for 3D structures and its relationship with drug dissolution from controlled release dosage forms.…”
The fractal dimension can be used as a quantitative indicator reflecting the drug release performance and be regarded as a key indicator for the quality control of oral controlled drug delivery systems.
“…The fractal dimension exhibited a major decrease in value during swelling and was highly correlated with the swelling ratio, thus indicating that the fractal dimension provided an interesting quantitative parameter related to surface roughness. For solid pharmaceutical dosage forms, D f values derived from surface imaging techniques have been employed to characterize the surface morphology of particles, mainly focusing on 2D static measurements, such as scanning electron microscopy and atomic force microscopy . Information on surface roughness and shape for particles and tablets has been gained from the values of fractal dimensions.…”
Section: Introductionmentioning
confidence: 99%
“…For solid pharmaceutical dosage forms, Df values derived from surface imaging techniques have been employed to characterize the surface morphology of particles, mainly focusing on 2D static measurements, such as scanning electron microscopy and atomic force microscopy. [16][17][18][19] Information on surface roughness and shape for particles and tablets has been gained from the values of fractal dimensions. However, there are few publications focusing on fractal analysis for 3D structures and its relationship with drug dissolution from controlled release dosage forms.…”
The fractal dimension can be used as a quantitative indicator reflecting the drug release performance and be regarded as a key indicator for the quality control of oral controlled drug delivery systems.
Bradford Scholars -how to deposit your paper
Overview
Copyright check• Check if your publisher allows submission to a repository.• Use the Sherpa RoMEO database if you are not sure about your publisher's position or email openaccess@bradford.ac.uk.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.