Evaluation of systolic and diastolic properties of hypertensive heart failure using speckle-tracking echocardiography with high volume rates

Minatoguchi, Shingo; Kawasaki, Masanori; Tanaka, Ryuhei; Yoshizane, Takashi; Ono, Katsushige; Saeki, Makio; Nagaya, Maki; Sato, Hidemaro; Nishigaki, Kazuhiko; Noda, Toshiyuki; Zile, Michael R.

doi:10.1007/s00380-017-0995-2

Cited by 11 publications

(6 citation statements)

References 29 publications

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“…The initial search produced 103 studies and with one identified through other sources, 104 studies were screened and then relevant studies were assessed and evaluated for inclusion (Figure 1). Eight studies were included for quantitative synthesis (Table 1) [17,[19][20][21][22][23][24][25][26]. Excluded were studies that focused on HFpEF in animal models [23].…”

Section: Resultsmentioning

confidence: 99%

Assessing cardiac contractility in hypertension with heart failure with preserved ejection fraction: the value of left ventricular strain

Rabkin

2023

Exploration of Medicine

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Aim: Hypertension (HTN) is a major cause of heart failure but the precise pathways by which HTN leads to heart failure are not resolved. Newer echocardiographic techniques permit assessment of myocardial contraction in different orientations defining left ventricular (LV) shortening as percentage longitudinal, circumferential and radial strain. Methods: A systematic search was conducted of Medline and Embase. The search was conducted from the inception of each database on June 30, 2022. Search terms “left ventricular strain” or speckle tracking AND heart failure with preserved ejection fraction or diastolic dysfunction AND HTN. Results: Six studies were identified and subject to detailed review. LV ejection fraction (LVEF) was not significantly different in patients with heart failure with preserved ejection fraction (HFpEF) and HTN compared to individuals with or without HTN. Global longitudinal strain (GLS) and global circumferential strain (GCS) were significantly (P < 0.0001) different (lower) in patients with HFpEF and HTN compared to patients with HTN without HFpEF and control individuals without HTN or other conditions. In contrast, global radial strain (GRS) was not significantly (P < 0.054) different in patients with HFpEF and HTN compared to individuals without HTN or other conditions. GRS was significantly (P < 0.01) different in individuals with HFpEF and HTN compared to individuals with HTN. Conclusions: Assessment of LV strain is an important advance in the assessment of LV function in patients with HTN and HFpEF as it identifies patients with reduced LV strain while there was no difference in LVEF. GLS and GCS provide the best separation between patients with HFpEF and HTN compared to individuals with HTN without HFpEF. This study advances the possibility of redefining the classification of heart function and heart failure for patients with HTN by either classifying patients mainly by LV strain or sub-classifying patients with HTN and HFpEF by LV strain.

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Section: Resultsmentioning

confidence: 99%

Assessing cardiac contractility in hypertension with heart failure with preserved ejection fraction: the value of left ventricular strain

Rabkin

2023

Exploration of Medicine

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“…The full text review eliminated 32 reports, and 4 articles were added by ‘hand searching’ and examination of bibliographies of existing papers, eventually, 19 articles could be included in the systematic review. 18 studies had a control group and one study compared patients with hypertension with and without left ventricular hypertrophy [ 19 , 20 , 21 , 22 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ] ( Supplementary Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…For studies of left ventricular strain, the patient characteristics of the studies demonstrate a range of mean ages, from 29 to 70 years (Table 1 , Ref. [ 19 , 20 , 21 , 22 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ]). The majority of studies had a mean age in the 50 years age group.…”

Section: Resultsmentioning

confidence: 99%

“…In order to explore whether left ventricular hypertrophy impacted the changes in left ventricular strain, an analysis was conducted on the subset of studies that evaluated LV strain in patients with hypertension with and without LVH (Table 3 , Ref. [ 20 , 25 , 26 , 29 , 30 , 33 , 36 , 37 ]). Most, but not all, studies, used the same definition of LVH.…”

Section: Resultsmentioning

confidence: 99%

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Assessing Myocardial Strain and Myocardial Work as a Marker for Hypertensive Heart Disease: A Meta-Analysis

Rabkin

2023

Rev. Cardiovasc. Med.

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Background: The main objective of this study was to determine whether myocardial strain and myocardial work are altered in hypertension and whether the strain is independent of hypertension-induced left ventricular hypertrophy. Methods: Two systematic literature searches were conducted using Medline and EMBASE through to June 30, 2022. In the first, search terms left ventricular strain or speckle tracking AND hypertension and left ventricular hypertrophy were used in conjunction with Boolean operators to identify articles reporting left ventricular strain in patients with hypertension. In the second, the terms Global cardiac or myocardial work AND hypertension were used to identify articles. Publication bias was assessed by examination of funnel plots and calculation of the Failsafe N and Duval and Tweedie’s Trim and fill. The results were presented as Forrest plots. Results: Global longitudinal strain (GLS) was significantly lower in patients with hypertension compared to those without hypertension with a mean difference of 2.0 0.1 (standard error of mean(SEM)) in the fixed effect model. Global circumferential strain (GCS) was significantly lower in hypertension. The mean difference between the hypertensive and non-hypertensive groups was 1.37 0.17. Global radial strain (GRS) was significantly ( p 0.05) greater in hypertension. However, this difference was significant in only 3 and of borderline significance in 3 of 14 studies where GRS was measured. The mean difference between the hypertensive and non-hypertensive groups was 1.5 0.5 using the fixed effects model. There was a significant relationship between GLS and GCS as well as between GCS and GRS but no significant relationship between GLS and GRS. There was no significant difference in left ventricular ejection fraction (LVEF) between the hypertension and no hypertension groups. There was no significant relationship between LVEF and either GLS or GCS but a significant negative correlation was found between LVEF and GRS. GLS was further reduced in persons with hypertension and left ventricular hypertrophy (LVH) compared to hypertension without LVH. In contrast, there were no or minimal differences in GCS and GRS for individuals with hypertension and LVH compared to those without LVH. Global myocardial work index (GWI) and Global constructive work (GCW) were significantly greater in patients with hypertension compared to controls. Global wasted work (GWW) indicated significantly less wasted work in controls compared to hypertension. In contrast, Global work efficiency (GWE) was significantly lower in hypertension compared to the control. Conclusions: There was a significant reduction in GLS and GCS in hypertension while GRS was increased. The reduction in GLS in hypertension was not dependent on the presence of LVH. GLS was further reduced in per...

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“…It enables us to evaluate myocardial deformity and thereby the assessment of global and regional functions. There has been a technological transition of myocardial deformation analysis from tissue Doppler imaging to two-dimensional (2D) 1 and the latest three-dimensional (3D) speckle tracking echocardiography (STE) methods. 2 Despite significant improvements in available HF treatment regimens, the 12-month all-cause mortality of 17% in hospitalized patients and 7% in stable or ambulatory patients remains high.…”

Section: Introductionmentioning

confidence: 99%

The three‐dimensional speckle tracking echocardiography in distinguishing between ischaemic and non‐ischaemic aetiology of heart failure

et al. 2020

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Aims The aim of this pilot study was to compare selected three-dimensional speckle tracking echocardiography (3D STE) parameters in patients with ischaemic and non-ischaemic aetiology of heart failure (HF) and to identify indices that can differentiate the two pathologies. Methods and results Forty patients with left ventricular ejection fraction (LVEF) ≤ 40% were included to the study: 20 patients (age 63 ± 9.0 years, LVEF 29.0 ± 11.3%) with ischaemic cardiomyopathy and 20 patients (age 64.0 ± 11.0 years, LVEF 27.3 ± 7.5%) with non-ischaemic cardiomyopathy. All patients underwent two-dimensional (2D) and three-dimensional (3D) transthoracic echocardiography. Standard echocardiographic parameters, global longitudinal strain, and rotational parameters of left ventricle (LV) were assessed using 3D speckle tracking (3D STE). There were no differences in standard and STE parameters between the two groups. Among rotational parameters, the LV apical rotation (4.9 ± 3.5°vs. 2.3 ± 2.4°, P = 0.0022) was significantly higher in patients with ischaemic HF. Among all echocardiographic parameters, a cutoff value of 3.28°(area under the curve 0.78; 95% confidence interval, 0.62 to 0.93) was able to distinguish the ischaemic and non-ischaemic aetiology of HF with a sensitivity of 80% and specificity of 75%. Conclusions This is the first study that compares 3D STE parameters between patients with ischaemic and non-ischaemic cardiomyopathy. It was proved that the apical rotation was significantly higher in patients with ischaemic cardiomyopathy. Our findings suggest that 3D STE might be useful in non-invasive differentiation between ischaemic and non-ischaemic aetiology of HF.

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Evaluation of systolic and diastolic properties of hypertensive heart failure using speckle-tracking echocardiography with high volume rates

Cited by 11 publications

References 29 publications

Assessing cardiac contractility in hypertension with heart failure with preserved ejection fraction: the value of left ventricular strain

Assessing cardiac contractility in hypertension with heart failure with preserved ejection fraction: the value of left ventricular strain

Assessing Myocardial Strain and Myocardial Work as a Marker for Hypertensive Heart Disease: A Meta-Analysis

The three‐dimensional speckle tracking echocardiography in distinguishing between ischaemic and non‐ischaemic aetiology of heart failure

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