Evaluation of Synergistic Interactions on Antioxidant and Anticancer Efficacy of Methanol Extracts of some Egyptian Spices in Combination

Farouk, Amr; Ramadan, Manal M.; Fekry, Reda M.; Salem, Marwa T.; Mohammad, Ayman A.; Ali, Mamdouh M.; Mohammed, Noha

doi:10.3923/ijbc.2017.9.16

Cited by 6 publications

(3 citation statements)

References 38 publications

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“…Furthermore, the recorded activity was better than that of the positive control, ascorbic acid (EC 50 = 10.25 µg/mL). Gupta et al [ 25 ] and Mansour et al [ 26 ] in their studies also reported high DPPH radical scavenging activity for C. zeylanicum methanol extracts, though the values were expressed as % DPPH inhibition. Kim et al [ 11 ] reported C. zeylanicum water extract to possess a higher DPPH radical scavenging activity compared to other spice extracts.…”

Section: Resultsmentioning

confidence: 99%

“…The combinations of M. piperita methanol extract with either C. zeylanicum or S. aromaticum extracts were antagonistic using the DPPH method. A study by Mansour et al [ 26 ] reported synergistic antioxidant effects from a combination of C. zeylanicum and S. aromaticum methanol extracts with the DPPH assay. Similarly, Purkait et al [ 23 ] reported synergy from combining the two oils using the DPPH assay.…”

Section: Resultsmentioning

confidence: 99%

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Optimization of Antioxidant Synergy in a Polyherbal Combination by Experimental Design

et al. 2022

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Culinary herbs and spices are known to be good sources of natural antioxidants. Although the antioxidant effects of individual culinary herbs and spices are widely reported, little is known about their effects when used in combination. The current study was therefore undertaken to compare the antioxidant effects of crude extracts and essential oils of some common culinary herbs and spices in various combinations. The antioxidant interactions of 1:1 combinations of the most active individual extracts and essential oils were investigated as well as the optimization of various ratios using the design of experiments (DoE) approach. The 2,2- diphenyl-1- picrylhydrazyl (DPPH), 2,2- azinobis (3- ethylbenzothiazoline- 6- sulphonic acid) (ABTS), and ferric reducing antioxidant power (FRAP) assays were used to determine the antioxidant activity, and MODDE 9.1® software (Umetrics AB, Umea, Sweden) was used to determine the DoE. The results revealed synergism for the following combinations: Mentha piperita with Thymus vulgaris methanol extract (ΣFIC = 0.32 and ΣFIC = 0.15 using the DPPH and FRAP assays, respectively); Rosmarinus officinalis with Syzygium aromaticum methanol extract (ΣFIC = 0.47 using the FRAP assay); T. vulgaris with Zingiber officinalis methanol extracts (ΣFIC = 0.19 using the ABTS assay); and R. officinalis with Z. officinalis dichloromethane extract (ΣFIC = 0.22 using the ABTS assay). The DoE produced a statistically significant (R2 = 0.905 and Q2 = 0.710) model that was able to predict extract combinations with high antioxidant activities, as validated experimentally. The antioxidant activities of the crude extracts from a selection of culinary herbs and spices were improved when in combination, hence creating an innovative opportunity for the future development of supplements for optimum health.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Optimization of Antioxidant Synergy in a Polyherbal Combination by Experimental Design

et al. 2022

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“…Recent studies by Britto [65] and Diez [66] have established the synergistic antimicrobial effects of certain herbs in combination, while research conducted by Bag [67] and Mansour [68] has illustrated the synergistic antioxidant activity of herbs and spices. There are several herbs used in the prakshape that have synergistic effects.…”

Section: Direct Synergistic Effectsmentioning

confidence: 99%

Prakshape condiment in Chavanprash: Harnessing Synergy of the Ages

2023

Curr Res Cmpl Alt Med

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Towards the conclusion of the tedious process of preparing chavanprash, a powdered herb combination known as prakshape is introduced. Many of these herbs have already been utilized in the initial stage of creating the decoction, which is the basis of chavanprash. The perplexing aspect is the necessity to incorporate the same herbs once more as prakshape during the final step, highlighting the intriguing nature of this addition and its associated benefits. The inclusion of prakshape proves to be ingenious for multiple reasons. Firstly, the incorporation of powdered herbs in prakshape ensures that the entire herb, along with all its phytochemical components, becomes part of the formulation. In contrast, the decoction process only extracts water -soluble components into the solution. This inclusion allows for a broader range of active compounds to be present in the final product. Secondly, the addition of prakshape serves to reintroduce volatile and heat-labile compounds that may have been lost during the extended heating process. Additionally, the inclusion of bamboo (Bambusa arundinacea) manna particles in prakshape contributes to an enhanced drug-delivery system. From a pharmacological standpoint, the incorporation of prakshape ingredients reinforces the therapeutic effects of the formulation and promotes synergy among the herbs. The principles underlying the use of prakshape can further be utilized for the development of new awaleha and ksheerpak formulations, potentially yielding more potent effects.

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