Evaluation of symmetric dimethylarginine in cats with acute kidney injury and chronic kidney disease

Loane, Samantha; Thomson, J M; Williams, Timothy; McCallum, Katie

doi:10.1111/jvim.16497

Cited by 6 publications

(5 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Resultsmentioning

confidence: 99%

“…Although diagnosis should never be limited to a single renal biomarker, aberrant sSDMA results because of delayed analysis might complicate the diagnosis and staging of CKD. The extent of these clinical errors in a subsample of animals with normal (<18 μg/dL) and increased sSDMA concentrations (≥18 μg/dL) 30,31 is summarized in Table 2. Age in years 6.5 ( F I G U R E 2 Visualization of the (pre-)analytical conditions that were subjected to a pairwise comparison of means and to an equivalence test (on the left side of the figure).…”

Section: Effect Of Preanalytical Storage Time and Temperature On Ssdm...mentioning

confidence: 99%

“…The results are based on comparison with the "true values" as assessed by the CL (T0 RT ) and based on the sSDMA cut-off concentration of 18 μg/dL. Patients with diagnosed acute kidney injury (AKI; n = 5) were omitted from this table because suitability of SDMA for diagnosing and grading AKI has not yet been fully assessed 30,31. Abbreviations: CKD, chronic kidney disease; IRIS, International Renal Interest Society; RT, room temperature; sSDMA, serum symmetric dimethylarginine.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Effect of storage temperature and time on measurement of serum symmetric dimethylarginine concentration using point‐of‐care and commercial laboratory analyzers in cats and dogs

Brans

Marynissen

Mortier

et al. 2023

Veterinary Internal Medicne

View full text Add to dashboard Cite

BackgroundStability of serum symmetric dimethylarginine (sSDMA) during short‐ and long‐term storage has not been assessed for the immunoassay of the Point‐of‐Care IDEXX Catalyst DX (POC) analyzer and the Enzyme Multiplied Immunoassay Technique of IDEXX commercial laboratory (CL). Also, the agreement between both analyzers is questioned.ObjectivesTo determine (a) the effect of storage time and temperature on sSDMA measured by POC and CL; (b) the agreement between sSDMA measured by POC and CL; and (c) the imprecision of the POC.AnimalsSerum of cats (n = 17) and dogs (n = 18) with a range of SDMA concentrations (6 to >100 μg/dL).MethodsBased on an equivalence trial with predefined equivalence range (−3.0 to +3.0 μg/dL) and using T0 as baseline, stability was evaluated after 24 hours at 22°C and 4°C (POC); after 7 days at 4°C (POC and CL) and after 10 and 24 months at −24°C and −80°C (CL). Bland‐Altman plots enabled method comparison. Imprecision of the POC was assessed by duplicate sSDMA measurements at T0.ResultsThe POC analyzer produced equivalent sSDMA measurements if samples were stored for 24 hours at 4°C (95% confidence interval [CI]: −2.5‐2.0 μg/dL), but not when stored for 24 hours at room temperature (RT; 95% CI: −4.1 to 0.5 μg/dL) or after 7 days at 4°C (95% CI: −3.6‐1.0 μg/dL). The CL analyzer was less affected by preanalytical variation with clinically similar results obtained when samples were stored for 7 days at 4°C (95% CI: −2.2 to 2.4 μg/dL) and for at least 24 months at −24°C (95% CI: −1.7 to 2.9 μg/dL) and −80°C (95% CI: −1.5 to 3 μg/dL). A relevant mean difference of −2.3 μg/dL between both analyzers was found. Duplicate POC measurements were equivalent (95% CI: −2.6 to 2.0 μg/dL).ConclusionsDelayed analysis may significantly change sSDMA depending on storage and measurement conditions. Interchangeable use of assays should be done with caution because analytical variation could be interpreted as clinically relevant change.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Effect Of Preanalytical Storage Time and Temperature On Ssdm...mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Effect of storage temperature and time on measurement of serum symmetric dimethylarginine concentration using point‐of‐care and commercial laboratory analyzers in cats and dogs

Brans

Marynissen

Mortier

et al. 2023

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…O biomarcador sérico Dimetilarginina simétrica (SDMA) é um aminoácido cujas elevações nas concentrações séricas indicam proteólise que é exclusivamente excretada pelos rins (Hall et al, 2014). Cerca de 90% de sua excreção é renal e o aumento das concentrações séricas podem indicar a redução na TFG (Loane et al, 2022). De acordo com Dahlem et al (2017), a molécula pode indicar tanto a LRA quanto a DRC; porém, não foi possível diferenciar o tipo de acometimento renal.…”

Section: Avaliação Laboratorial Do Paciente Crítico Com Lraunclassified

Uso de preditores clínicos e laboratoriais em cães em estado crítico na determinação de lesão renal aguda

Castro,

Duque,

Fioravanti

et al. 2024

Pubvet

View full text Add to dashboard Cite

Um paciente crítico consiste naquele que necessita de cuidados intensivos e que necessita de acompanhamento clínico e laboratorial adequado para garantir a vida. Nesses pacientes, existe uma condição com risco de vida, o que é importante para prevenir o agravamento das complicações e aumentar as taxas de sobrevivência e remissão. A lesão renal aguda (LRA) é a síndrome mais frequentemente observada entre esses pacientes. O principal objetivo da terapia intensiva é prevenir o desenvolvimento de LRA em pacientes gravemente enfermos, uma vez que pode reduzir a função renal, diminuir a taxa de filtração glomerular (TFG), o débito urinário (DU), a produção de urina e a disfunção dos túbulos renais. A maior limitação é a detecção precoce da LRA, uma vez que os exames tradicionais para avaliação renal apresentam limitações para confirmar a síndrome. O uso de biomarcadores tem se mostrado promissor na sua detecção, como a enzima urinária gama glutamil transferase (GGTu). O GGTu tem sido amplamente estudado, pois parece ser capaz de detectar danos aos túbulos renais e determinar LRA. Esta revisão tem como objetivo correlacionar função renal e morfologia por meio de painéis diagnósticos em pacientes críticos para identificação de LRA.

show abstract

“…Hence, these biomarkers cannot predict the renal function based on their concentration before decompression [ 11 ]. In AKI in cats, however, SDMA is useful when there is a sedimented AKI [ 12 ]. In the face of these findings, it is believed that in feline UO, SDMA may work as a biomarker for the early detection of chronic kidney disease (CKD) cats in which an irreversible kidney injury has been established after a long time of UO.…”

Section: Introductionmentioning

confidence: 99%

Symmetric dimethylarginine correlates with the urea, creatinine, potassium, and clinical scores in feline urethral obstructions

Nóbrega,

Dinallo,

Geraldes

et al. 2024

J Vet Sci

View full text Add to dashboard Cite

Background A urethral obstruction (UO) is an emergency commonly observed in male cats, which can result in significant clinical and laboratory alterations, leading to complications and death. Objectives This study aimed to correlate symmetric dimethylarginine (SDMA) with the urea, creatinine, potassium, and bicarbonate levels in cats with UO. In addition, the correlation between clinical score and time of obstruction was evaluated. Methods Thirty male cats were selected and allocated into a control group (CG, n = 13) and an obstruction group (OG, n = 17). The laboratory analyses were conducted before treatment (M0) and at different times after treatment (12 h [M12], 24 h [M24], and 48 h [M48]). Correlations were established between SDMA and creatinine, urea, bicarbonate, potassium, time of obstruction, and the clinical score. Results A strong correlation (r > 0.6) was observed between SDMA and creatinine, urea, and potassium in the OG. Furthermore, there was substantial agreement (kappa value) between SDMA and creatinine at M24. A higher clinical score was associated with a longer time of obstruction. In the OG, at M48, the SDMA and creatinine levels were 50% and 41.2% higher, respectively. Conclusions A correlation was observed between SDMA and creatinine in obstructed cats, and significant agreement between these values was observed 24 h after the unblocking treatment. A correlation among SDMA, urea, and potassium was observed. Approximately 9% more cats continued to have elevated SDMA levels after 48 h of treatment compared to creatinine. This suggests a slightly lower sensitivity of the latter biomarker but does not exclude the possibility of congruent and normalized values after a longer evaluation period.

show abstract

Evaluation of symmetric dimethylarginine in cats with acute kidney injury and chronic kidney disease

Cited by 6 publications

References 53 publications

Effect of storage temperature and time on measurement of serum symmetric dimethylarginine concentration using point‐of‐care and commercial laboratory analyzers in cats and dogs

Effect of storage temperature and time on measurement of serum symmetric dimethylarginine concentration using point‐of‐care and commercial laboratory analyzers in cats and dogs

Uso de preditores clínicos e laboratoriais em cães em estado crítico na determinação de lesão renal aguda

Symmetric dimethylarginine correlates with the urea, creatinine, potassium, and clinical scores in feline urethral obstructions

Contact Info

Product

Resources

About