Evaluation of sweating responses in patients with collagen disease using the quantitative sudomotor axon reflex test (QSART): a study protocol for an investigator-initiated, prospective, observational clinical study

Ashida, Miwa; Koga, Tomohiro; Morimoto, Shimpei; Yozaki, Mariko; Ehara, Daisuke; Koike, Yuta; Murota, Hiroyuki

doi:10.1136/bmjopen-2021-050690

Cited by 4 publications

(5 citation statements)

References 22 publications

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“…Quantitative sudomotor axon reflex test (QSART) is designed to stimulate the autonomic nervous system and evaluate how nerves that regulate sweat glands responds to stimulation. A SSc QSART protocol for skin symptoms (digital ulcers, pernio-like eruptions, subcutaneous calcifications, telangiectasia, nailfold capillary dilatation/bleeding and degree of skin sclerosis) and skin surface temperature is under investigation in Japan for a observational clinical study [59]. This study adopts two evaluation points, summer and winter, to observe effects of temperature on sweating.…”

Section: Vascular Functional Studies With Peripheral Arterial Tonomet...mentioning

confidence: 99%

Imaging techniques for assessment of vascular involvement in systemic sclerosis

Frech

2022

Current Opinion in Rheumatology

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Purpose of reviewVascular assessment in systemic sclerosis (SSc) is included in classification criteria for this disease, thus routinely used in the evaluation of patients in which this diagnosis is being considered. In this review, imaging techniques for assessment of vascular involvement in SSc hands and skin are discussed. Recent findingsLongitudinal use of imaging techniques has important implications for understanding the progressive vasculopathy and fibrotic transition in SSc. Nailfold and oral capillaroscopy as well as laser speckle contrast analysis are established techniques for vascular functional assessment, but longitudinal use is challenged by equipment costs and clinical time constraints. Ultrasound techniques are well described but require technical training. Advances in mobile infrared thermography and optical coherence tomography could potentially provide a point-of-care, quantitative outcome measure in clinical trials and practice.

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Section: Vascular Functional Studies With Peripheral Arterial Tonomet...mentioning

confidence: 99%

Imaging techniques for assessment of vascular involvement in systemic sclerosis

Frech

2022

Current Opinion in Rheumatology

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“…We analyzed the association of the ARSV with the severity of Raynaud's activity, defined by the RCS. The total scores were dichotomized as low scores (0–7) and high scores 8–16 (Figure 3a). Values for the subcomponents of attack, pain, color, and duration were dichotomized into those without symptoms (0) and those with symptoms (≥1) (Figure 3b).…”

Section: Resultsmentioning

confidence: 99%

“…This study was conducted according to the study protocol, 15 which is available at the Japan registry of clinical trials.…”

Section: Methodsmentioning

confidence: 99%

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Evaluation of sweating responses in patients with systemic connective tissue disorders using the quantitative sudomotor axon reflex test

Ashida

Morimoto

Yozaki

et al. 2022

J Cutaneous Imm & Allergy

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In systemic connective tissue disorders (SCTDs), eccrine sweat glands are frequently attacked by immune cells, as evidenced by pathological observations. Sweating re ects vascular activity through the autonomic nervous system, while few studies have reported sweating ability in SCTDs or the relationship between sweating ability and Raynaud's phenomenon caused by sympathetic hyperreactivity. We performed the quantitative sudomotor axon re ex test on 85 patients diagnosed with systemic sclerosis, mixed connective tissue disease, systemic lupus erythematosus, Sjogren's syndrome, and dermatomyositis. Evaluations were performed once in summer and once in winter. We investigated the relationship of the axon re ex sweat volume and the reaction time to Raynaud's phenomenon, skin symptoms, and patient background. Most patients did not show a decrease in sweating compared to healthy participants, but patients with systemic sclerosis who were positive for anti-RNA polymerase III antibodies showed little or no sweating. One in three patients showed less sweating in summer than in winter, which is the opposite of the normal seasonal variation. Although no relationship was observed between the sweat volume and the total Raynaud's condition scores, patients with pain had more sweating than those without pain. These results suggested the possible utility of measuring sweating on autonomic peripheral circulatory disorders.

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“…Autonomic dysfunction is an important factor of morbidity and mortality among children living with diabetes [ 23 , 24 ], the common evaluations include heart rate, blood pressure, sweating abnormalities, as well as the callus. However, some subjective questionnaires do not reflect any differences between the patients and healthy controls, whereas some objective function tests have not been used in children, owing to higher demand for cooperation or lack of specialized equipment [ 25 , 26 ]. Autonomic neuropathy in children with T1DM is likely underestimated due to suboptimal screening and subclinical neuropathy [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of sympathetic skin response for early diagnosis and follow-up of diabetic peripheral neuropathy in children

Jin,

Liu,

Liu

et al. 2023

BMC Pediatr

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Background The morbidity of type 1 diabetes mellitus (T1DM) in children is increasing and diabetic peripheral neuropathy (DPN) is one of the main microvascular complications of T1DM. The aim of this study was to explore sympathetic skin response (SSR) characteristics in children with T1DM and analyze the value of early diagnosis and follow-up in T1DM complicated with DPN. Methods Our prospective study enrolling 85 participants diagnosed with T1DM and 30 healthy controls (HCs) in the Children’s Hospital of Hebei Province from 2017 to 2020. Compared the outcomes of SSR and nerve conduction study (NCS) in T1DM, and evaluated the variations in SSR and NCS of different durations, as well as changes after six months of therapy. Results SSR latency of T1DM group showed statistical difference as compared to HCs (p < 0.05). The SSR test was more sensitive than the NCS test in the early diagnosis of T1DM with DPN (p < 0.05). The abnormal rates of SSR and NCS in long duration of disease were higher than those in short duration of disease (p < 0.05). Among 65 participants with diabetic neuropathy, the onset latencies of SSR were shortened and the NCS were improved after treatment (p < 0.05). Conclusions SSR could provide the accurate early diagnosis and follow-up of pediatric diabetic peripheral neuropathy.

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Evaluation of sweating responses in patients with collagen disease using the quantitative sudomotor axon reflex test (QSART): a study protocol for an investigator-initiated, prospective, observational clinical study

Cited by 4 publications

References 22 publications

Imaging techniques for assessment of vascular involvement in systemic sclerosis

Imaging techniques for assessment of vascular involvement in systemic sclerosis

Evaluation of sweating responses in patients with systemic connective tissue disorders using the quantitative sudomotor axon reflex test

Evaluation of sympathetic skin response for early diagnosis and follow-up of diabetic peripheral neuropathy in children

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