Evaluation of surgical margins according to the histological type of basal cell carcinoma

Godoy, Charles Antônio Pires de; Neta, Alice Lima de Oliveira; Leão, Sofia Silveira de Souza; Dantas, Raul Lima; Carvalho, Valeska Oliveira Fonseca; Silva, Samuel Freire da

doi:10.1590/abd1806-4841.20175076

Cited by 8 publications

(11 citation statements)

References 11 publications

(29 reference statements)

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“…In our study, the most histologically famous subtype was, the nodular (60%), then superficial (17.5%), fibrosing (12.5%), and pigmented (10%). This matches with Godoy et al (10) who found that nodular type of BCC is the predominant one, it accounts for 60%.…”

Section: Discussionsupporting

confidence: 91%

“…The range of our patient's age was from 38-79 years, with a mean of 56.42±8.8 years, this matches with Godoy et al (10) , who suggested that the incidence of 55-75 years, is nearly 100 times higher in patients younger than 20 years.…”

Section: Discussionsupporting

confidence: 91%

“…In this study we aim to clear basal cell carcinoma with a least adequate surgically free border, in order to gain a negative pathologic boundary with the least surgical margin (10) .…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of The Best Surgical Margin for Basal Cell Carcinoma

Ismail¹,

Abdelwabab

Yassin

et al. 2021

The Egyptian Journal of Hospital Medicine

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Background: Basal cell carcinoma (BCC) is one of the non-melanocytic malignancies of the skin, originating from the epidermal basal cells. It is considered the most common skin malignancy in humans. The treatment should remove the lesion with preserving the maximum level of healthy surrounding tissues. So, treatment is controversial between adequate safety margin and leaving satisfactory cosmetic results. Objective: In this study, we aim to evaluate the intact safety margin for BCC post-operative, being regarded as 3 mm or more before surgery (pathologically by routine and immunohistochemical staining using BerEP4). Patients and Methods: The study included 40 patients presented with basal cell carcinoma (BCC). All were assessed for the duration, size, type, and site of the lesion. The treatment of the primary lesion and recurrence time was reported for all cases. Different reconstructive types of local fascio-cutaneous flaps were performed. The excised specimens were referred to pathological verification of the diagnosis and evaluation of the boundaries, either free or infiltrated. Results: There was a statistically significant association between recurrence and tumor size (p=0.001), deep facial invasion (p<0.001), muscle invasion (p=0.001), ill-defined tumor borders (p<0.001), positive surgical margins, and safety margins size (p<0.001). Conclusion: Excision of BCC with 3 mm or more as a safety margin is enough to preserve healthy tissues and avoid the requirement for difficult procedures of reconstruction. The use of BerEP4 is a highly specific marker for detecting BCC cells that, can be missed by routine H&E staining.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

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Evaluation of The Best Surgical Margin for Basal Cell Carcinoma

Ismail¹,

Abdelwabab

Yassin

et al. 2021

The Egyptian Journal of Hospital Medicine

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“… 8 , 9 , 10 , 11 , 12 Head and neck tumors, especially in some topographic subregions and among less experienced professionals, appear to be associated more with compromised or inadequate margins compared to BCC in other sites. 11 , 12 , 13 , 14 Herein, our main objective was to evaluate the clinical and pathological factors associated with inadequate surgical margins in head and neck BCC through an institutional series in a tertiary oncological center.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with incomplete surgical margins in basal cell carcinoma of the head and neck

Girardi

Wagner

Martins

et al. 2021

Brazilian Journal of Otorhinolaryngology

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“…The "gold standard" in BCC diagnostics is the pathomorphological study for determination of neoplasm type that is not only prognostic marker but also indicator of treatment method selection [12]. According to data of M. C. Cameron al.…”

Section: Discussionmentioning

confidence: 99%

Clinical case of basal cell carcinoma therapy using 5 % imiquimod cream

et al. 2020

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A-research concept and design; B-collection and/or assembly of data; C-data analysis and interpretation; D-writing the article; E-critical revision of the article; F-final approval of the article Aim. To describe clinical case of the basal cell carcinoma treatment, determine personalized diagnostic algorithm of the patient management with further selection of the therapy method regarding visual, dermatoscopic and pathomorphological picture of disease. Materials and methods. The own observation of clinical case of local treatment of the patient with basal cell carcinoma by means of 5 % imiquimod cream was described. Results. Based on comprehensive examination of the patient with determination of features of visual, dermatoscopic and pathohistological picture the diagnosis "Basal cell carcinoma, nodular variant" was determined. Taking into account considerable traumatization and possibility of functional motor impairment after surgery it was determined to replace the treatment approach with the local use of 5 % imiquimod cream according to the standardized scheme. Step-by-step application of topical agent on the upper part of BCC affected area had also influence on the non-treated zone which began to regress by itself starting from the 9 th week. Spontaneous regress of BCC stipulates rare and unusual course of disease. Control clinical and pathomorphological examination did not reveal any neoplastic processes in skin after 12 weeks course of treatment with 5 % imiquimod cream and within 1 year of further observation. In case of BCC the possibility of using topical agents increases therapeutic potential and compliance between doctor and patient. Conclusions. Annual increase of quantity of new cases of non-melanoma skin tumours and variability of clinical implications enable the rise of oncological suspicion level among practicing physicians. Creation of personalized algorithm of diagnostics ensures making the diagnosis timely and selection of differential treatment approach. Neglecting the neoplasm with significant affected area size the topical use of 5 % imiquimod is the effective alternative to invasive intervention for treatment of patients with the basal cell carcinoma.

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Evaluation of surgical margins according to the histological type of basal cell carcinoma

Cited by 8 publications

References 11 publications

Evaluation of The Best Surgical Margin for Basal Cell Carcinoma

Evaluation of The Best Surgical Margin for Basal Cell Carcinoma

Factors associated with incomplete surgical margins in basal cell carcinoma of the head and neck

Clinical case of basal cell carcinoma therapy using 5 % imiquimod cream

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