Evaluation of [<sup>89</sup>Zr]-Oxalate as a PET Tracer in Inflammation, Tumor, and Rheumatoid Arthritis Models

Park, Ji Ae; Lee, Yong Jin; Lee, Jiwoong; Yoo, Roh Eul; Shin, Un Chol; Lee, Kyo Chul; Kim, Kyeong Min; Kim, Jung Young

doi:10.1021/acs.molpharmaceut.6b00411

Cited by 16 publications

(18 citation statements)

References 26 publications

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“…Turpentine oil was purchased from Daejung Chemicals & Metals Co., Ltd. (Korea). Three days after turpentine treatment, mice were used for in vivo MRI experiments [ 20 ]. For the in vivo anti-inflammatory study, mice were randomly divided into four groups: normal (n = 5), turpentine oil (n = 8), turpentine oil and GdL (3) (n = 8), and turpentine oil and RosA (n = 7).…”

Section: Methodsmentioning

confidence: 99%

Gd-Complex of a Rosmarinic Acid Conjugate as an Anti-Inflammatory Theranostic Agent via Reactive Oxygen Species Scavenging

et al. 2020

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Rosmarinic acid (RosA), an important polyphenol, is known for its antioxidant and anti-inflammatory activities. However, its application in theranostics has been rarely reported. Therefore, a new single-molecule anti-inflammatory theranostic compound containing RosA would be of great interest. A gadolinium (Gd) complex of 1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid (DO3A) and RosA (Gd(DO3A-RosA)(H2O)) was synthesized and examined for use as a single-molecule theranostic agent. Its kinetic stability is comparable to that of clinically used macrocyclic magnetic resonance imaging contrast agents. In addition, its relaxivity is higher than that of structurally analogous Gd-BT-DO3A. This agent was evaluated for inflammatory targeting magnetic resonance contrast and showed strong and prolonged enhancement of imaging in inflamed tissues of mice. The theranostic agent also possesses antioxidant and anti-inflammatory activities, as evidenced by reactive oxygen species scavenging, superoxide dismutase activity, and inflammatory factors. The novel RosA-conjugated Gd complex is a promising theranostic agent for the imaging of inflamed tissues, as well as for the treatment of inflammation and oxidative stress.

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Section: Methodsmentioning

confidence: 99%

Gd-Complex of a Rosmarinic Acid Conjugate as an Anti-Inflammatory Theranostic Agent via Reactive Oxygen Species Scavenging

et al. 2020

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“…Data suggest that exploring the use of 89 Zr-oxalate to label WBCs ex vivo or even in vivo may be worthwhile. 37…”

Section: Other Pet Imaging Compoundsmentioning

confidence: 99%

Currently Available Radiopharmaceuticals for Imaging Infection and the Holy Grail

Salmanoglu

Kim

Thakur

2018

Seminars in Nuclear Medicine

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Infection is ubiquitous. However, its management is challenging for both the patients and the health-care providers. Scintigraphic imaging of infection dates back nearly half a century. The advances in our understanding of the pathophysiology of disease at cellular and molecular levels have paved the way to the development of a large number of radiopharmaceuticals for scintigraphic imaging of infection. These include radiolabeling of blood elements such as serum proteins, white blood cells (WBCs), and cytokines, to name a few. Infectious foci have also been imaged using a radiolabeled sugar molecule by taking advantage of increased metabolic activity in the infectious lesions. Literature over the years has well documented that none of the radiopharmaceuticals and associated procedures that facilitate imaging infection are flawless and acceptable without a compromise. As a result, only a few compounds such as Tc-hexamethylpropyleneamineoxime,F-FDG, the oldest but still considered as a gold standard In-oxine, and, yes, evenGa-citrate in some countries, have remained in routine clinical practice. Nonetheless, the interest of scientists and physicians to improve the approaches to imaging and to the management of infection is noteworthy. These approaches have paved the way for the development of numerous, innovative radiopharmaceuticals to label autologous WBCs ex vivo or even those that could be injected directly to image infection or inflammation without direct involvement of WBCs. In this review, we briefly describe these agents with their pros and cons and place them together for future reference.

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“…This occurs even when plasma oxalate values are within the normal range and kidney function is good. Oxalates are known to collect at sites of inflammation 132 and injury 133 where they delay healing or cause further damage. Attachment at sites of injured, inactive, stagnant tissue evades cellular clearance mechanisms, allowing minute deposits to grow and serve as sites of ongoing accumulation, owing to semicontinuous occurrence of oxalate in body fluids.…”

Section: Bioaccumulation Of Oxalatementioning

confidence: 99%

Lost Seasonality and Overconsumption of Plants: Risking Oxalate Toxicity

Norton¹

2017

jevohealth

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In many plants, oxalate crystals are present. These relatively large microcrystals have the potential to inflict mechanical injury. On the other hand, ionic, soluble, and nano-crystal forms of oxalate are readily absorbed. Bioaccumulation in humans is well documented. Crystals and ionic oxalate are associated with pain and both functional and chronic disorders. Today's many health challenges have led people to select foods purported to be healthier, many of which are high in oxalate. Modern dietary approaches have placed great emphasis on the health benefits of vegetables, nuts, and spices. Many of these are high oxalate foods that are now distributed through a global food system in which seasons have been erased, making harm from dietary oxalate more likely now than ever before. Lack of awareness of this potential creates fertile ground for continued increases in human suffering and public health problems.

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Evaluation of [⁸⁹Zr]-Oxalate as a PET Tracer in Inflammation, Tumor, and Rheumatoid Arthritis Models

Cited by 16 publications

References 26 publications

Gd-Complex of a Rosmarinic Acid Conjugate as an Anti-Inflammatory Theranostic Agent via Reactive Oxygen Species Scavenging

Gd-Complex of a Rosmarinic Acid Conjugate as an Anti-Inflammatory Theranostic Agent via Reactive Oxygen Species Scavenging

Currently Available Radiopharmaceuticals for Imaging Infection and the Holy Grail

Lost Seasonality and Overconsumption of Plants: Risking Oxalate Toxicity

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Evaluation of [89Zr]-Oxalate as a PET Tracer in Inflammation, Tumor, and Rheumatoid Arthritis Models

Cited by 16 publications

References 26 publications

Gd-Complex of a Rosmarinic Acid Conjugate as an Anti-Inflammatory Theranostic Agent via Reactive Oxygen Species Scavenging

Gd-Complex of a Rosmarinic Acid Conjugate as an Anti-Inflammatory Theranostic Agent via Reactive Oxygen Species Scavenging

Currently Available Radiopharmaceuticals for Imaging Infection and the Holy Grail

Lost Seasonality and Overconsumption of Plants: Risking Oxalate Toxicity

Contact Info

Product

Resources

About

Evaluation of [⁸⁹Zr]-Oxalate as a PET Tracer in Inflammation, Tumor, and Rheumatoid Arthritis Models