2014
DOI: 10.1016/j.fct.2013.11.001
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Evaluation of subchronic inhalation toxicity of methylcyclopentane in rats

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Cited by 12 publications
(4 citation statements)
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“…As the changes in liver weight appeared to be evidence of adaptive rather than adverse processes and the hematological changes were within the normal range, the no adverse effect concentration for both rats and mice was judged to be 7000 ppm (21000 mg/m 3 ), the highest concentration tested. Yang et al (2014) reported a study in which rats were exposed by inhalation, 6 hours/day and 5 days/week for 13 weeks, at levels of 290, 1300, or 5870 ppm (880, 3900, or 18000 mg/ m 3 ). Following the exposure period, the surviving animals were sacrificed and examined at the gross and microscopic levels.…”
Section: Repeated Dose Toxicity Studies Of Cyclohexanementioning
confidence: 99%
“…As the changes in liver weight appeared to be evidence of adaptive rather than adverse processes and the hematological changes were within the normal range, the no adverse effect concentration for both rats and mice was judged to be 7000 ppm (21000 mg/m 3 ), the highest concentration tested. Yang et al (2014) reported a study in which rats were exposed by inhalation, 6 hours/day and 5 days/week for 13 weeks, at levels of 290, 1300, or 5870 ppm (880, 3900, or 18000 mg/ m 3 ). Following the exposure period, the surviving animals were sacrificed and examined at the gross and microscopic levels.…”
Section: Repeated Dose Toxicity Studies Of Cyclohexanementioning
confidence: 99%
“…Of all adverse clinical signs observed, salivation and abdominal distension probably resulted from irritation of the oral mucosa and gastrointestinal track by ZnO AE100(+) . Salivation is often observed in gavage studies and may have been a reaction to the taste or mucosal irritation of the test article [ 17 18 19 20 ]. Fur loss and weakness were indications of stress and/or malnutrition induced by ZnO AE100(+) , which is supported by the decreases in body weight and feed consumption.…”
mentioning
confidence: 99%
“…** Significant difference from the control group at P < 0.01. system by TCS, which acts as a skin, eye, and respiratory system irritant in humans and experimental animals (Steinkjer and Braathen, 1988;EPA, 2008). It is well known that salivation is often observed after exposure to irritant substances by inhalation, and salivation may be a reaction to the irritation by TCS (Duffus, 1993;Yu et al, 2011;Yang et al, 2014). The limited acute inhalation toxicity data indicate that acute exposure to TCS causes respiratory system irritation when rats are exposed to 1.3 mg/L by inhalation for 2 h (Leutkemeier et al, 1974).…”
Section: Parametermentioning
confidence: 95%
“…known to occur commonly in rats (Boorman et al, 1990;Greaves, 1990;Haschek and Rousseaux, 1998;Kim et al, 2009;Yang et al, 2014).…”
Section: Tablementioning
confidence: 96%