Evaluation of strongyloidiasis in kennel dogs and keepers by parasitological and serological assays

Gonçalves, Ana Lúcia Ribeiro; Machado, Gleyce Alves; Gonçalves-Pires, M.R.F.; Ferreira-Júnior, A.; Silva, D.A.O.; Costa-Cruz, Júlia Maria

doi:10.1016/j.vetpar.2007.03.016

Cited by 36 publications

(36 citation statements)

References 33 publications

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“…Thus, keeping rats infected with S. ratti would be much easier than mantaining monkeys (Campos et al 1988) or dogs (Gonçalves et al 2007) with S. stercoralis. Therefore, S. ratti larvae can be an adequate substitute antigen of S. stercoralis using ELISA (Costa-Cruz et al 1997, 2003.…”

Section: Discussionmentioning

confidence: 99%

IgG1, IgG4, and IgE antibody responses in human strongyloidiasis by ELISA using Strongyloides ratti saline extract as heterologous antigen

et al. 2007

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The aim of this study was to evaluate total IgG, IgG1, IgG4, and IgE antibody responses in human strongyloidiasis by enzyme-linked immunosorbent assay (ELISA) using Strongyloides ratti saline extract as heterologous antigen for a possible clinical utility of the assay. A total of 40 serum samples of patients who were shedding Strongyloides stercoralis larvae in feces (group I), 30 sera from patients with other intestinal parasites (group II), and 30 sera from subjects with negative results in three parasitological assays (group III) were analyzed to detect total IgG, IgG1, IgG4, and IgE to Strongyloides spp. by ELISA and expressed in ELISA index. Levels of total IgG anti-Strongyloides spp. were significantly higher in patients of group I than in groups II (p=0.0005) and III (p<0.0001). Levels of specific IgG1, IgG4, and IgE of group I were also significantly higher than in groups II and III, respectively. There was a significant positive correlation between specific IgE and IgG4 (r=0.6524; p=0.0084) and IgG1 and IgG4 (r=0.5398; p=0.0171). It can be concluded that the detection of specific IgE, IgG1, and IgG4 subclasses rather than total IgG antibodies to Strongyloides spp. using the S. ratti antigen showed to be an additional tool for improving the serodiagnosis of human strongyloidiasis.

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Section: Discussionmentioning

confidence: 99%

IgG1, IgG4, and IgE antibody responses in human strongyloidiasis by ELISA using Strongyloides ratti saline extract as heterologous antigen

et al. 2007

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“…Other than S. stercoralis and S. fuelleborni , two more species, S. myopotami and S. procyonis , are reported to infect animal hosts and may be responsible for zoonotic infections [25]. The adult female worm is a slender, almost transparent worm that measures 2.2 to 2.5 mm long, has a diameter of 50 µm, and lives in tunnels between enterocyte in the small intestine.…”

Section: Biology Of the Parasitementioning

confidence: 99%

Strongyloidiasis—An Insight into Its Global Prevalence and Management

et al. 2014

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Background Strongyloides stercoralis, an intestinal parasitic nematode, infects more than 100 million people worldwide. Strongyloides are unique in their ability to exist as a free-living and autoinfective cycle. Strongyloidiasis can occur without any symptoms or as a potentially fatal hyperinfection or disseminated infection. The most common risk factors for these complications are immunosuppression caused by corticosteroids and infection with human T-lymphotropic virus or human immunodeficiency virus. Even though the diagnosis of strongyloidiasis is improved by advanced instrumentation techniques in isolated and complicated cases of hyperinfection or dissemination, efficient guidelines for screening the population in epidemiological surveys are lacking.Methodology and ResultsIn this review, we have discussed various conventional methods for the diagnosis and management of this disease, with an emphasis on recently developed molecular and serological methods that could be implemented to establish guidelines for precise diagnosis of infection in patients and screening in epidemiological surveys. A comprehensive analysis of various cases reported worldwide from different endemic and nonendemic foci of the disease for the last 40 years was evaluated in an effort to delineate the global prevalence of this disease. We also updated the current knowledge of the various clinical spectrum of this parasitic disease, with an emphasis on newer molecular diagnostic methods, treatment, and management of cases in immunosuppressed patients.ConclusionStrongyloidiasis is considered a neglected tropical disease and is probably an underdiagnosed parasitic disease due to its low parasitic load and uncertain clinical symptoms. Increased infectivity rates in many developed countries and nonendemic regions nearing those in the most prevalent endemic regions of this parasite and the increasing transmission potential to immigrants, travelers, and immunosuppressed populations are indications for initiating an integrated approach towards prompt diagnosis and control of this parasitic disease.

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“…There is no gold-standard method for diagnosis of S. stercoralis (1,(7)(8)(9). In our study direct fecal smears and the Baermann method were preferred because they are cheap, easy, and less time-consuming.…”

Section: Resultsmentioning

confidence: 89%

First clinical Strongyloides stercoralis case in a dog in Turkey*

Umur¹,

Yücel²,

Bölükbaş³

et al. 2017

Turk J Vet Anim Sci

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IntroductionCanine strongyloidiasis is a zoonotic infection caused by the intestinal nematode Strongyloides stercoralis (1). The parasite is found generally in dogs and cats and also in humans worldwide, especially in tropical regions (2,3).S. stercoralis is an interesting nematode in several ways: only female nematodes are parasitic and it can multiply parthenogenetically in the host, and it has two life cycles, a free-living period and a parasitic period (3,4).Parasite morphology varies between the free-living and parasitic periods of the life cycle. The parasitic female is small and slender, nearly 2 mm in length. The tip of the tail is bluntly shaped and the esophagus is elongated and filariform, nearly filling the anterior half of the body length (4,5).Development of the larva is rapid under ideal conditions; the infective larval stage may be reached in about 2 days. Based on environmental conditions, some of the larvae develop into the parasitic form while others develop into free-living worms. The infective larvae (L 3 ) are transmitted via oral and percutaneous routes and also the transmammary pathway, but there is no placental infection in dogs (4,6,7).Infection usually occurs in shelters, where most puppies are affected, especially since a large number of dogs are hosted in small units, and in humid and hot seasons, sometimes due to poor hygienic conditions (7).

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Evaluation of strongyloidiasis in kennel dogs and keepers by parasitological and serological assays

Cited by 36 publications

References 33 publications

IgG1, IgG4, and IgE antibody responses in human strongyloidiasis by ELISA using Strongyloides ratti saline extract as heterologous antigen

IgG1, IgG4, and IgE antibody responses in human strongyloidiasis by ELISA using Strongyloides ratti saline extract as heterologous antigen

Strongyloidiasis—An Insight into Its Global Prevalence and Management

First clinical Strongyloides stercoralis case in a dog in Turkey*

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