Evaluation of Stress-related Behavioral and Biological Activity of Ocimum sanctum Extract in Rats

Amelioration effect of water extract from Ganoderma resinaceum FQ23 solid-state fermentation fungal substance with high-yield ergothioneine on anxiety-like insomnia mice

“…9(d) that the serum CRH, ACTH and CORT levels of the mice in the IC group were significantly up-regulated. With an increase in the GSW dose, the levels of CRH, ACTH and CORT in the anxiety-like insomnia mice significantly decreased, which is consistent with the HPA axis regulation mechanism of Ocimum sanctum extract 12 improving sleep. This indicates that GSW can help reduce the level of HPA axis hormones in anxiety-like insomnia mice.…”

“…1 Insomnia reduces the antioxidant capacity 2 and is associated with the dysregulation of the serotonin (5-HT) and gamma-aminobutyric acid (GABA) systems, [3][4][5][6][7][8][9][10] as well as increased hormone levels in the hypothalamic-pituitary-adrenal axis (HPA axis). [11][12][13][14] In addition, brain-derived neurotrophic factor (BDNF) signaling helps maintain sleep-related neural activity and plays an important role in brain development and synaptic plasticity. [14][15][16][17] Currently, the drugs commonly used to treat insomnia are benzodiazepines, 11 but their long-term use can cause side effects such as addiction, treatment rebound and withdrawal symptoms.…”

“…[14][15][16][17] Currently, the drugs commonly used to treat insomnia are benzodiazepines, 11 but their long-term use can cause side effects such as addiction, treatment rebound and withdrawal symptoms. 10 It is worth noting that the food and drug resources with the function of improving sleep include Ocimum sanctum, 12 ginsenoside, 10 Ziziphus jujube seed 18 and Ganoderma lucidum (G. lucidum), 19,20 which are rich in a variety of active ingredients and play a wide role in physiological regulation, thus having the potential to assist or replace drugs in the treatment of insomnia. Therefore, it is necessary to give fully consider the role of novel food and medicine resources in the prevention and treatment of insomnia symptoms.…”

Ocimum tenuiflorum extract (HOLIXERTM): Possible effects on hypothalamic–pituitary–adrenal (HPA) axis in modulating stress

“…An ethanol extract of leaves of Ocimum sanctum was reported to prevent the noise-stress induced increase in corticosterone in Wistar rats at an intraperitoneal dose of 100 mg/kg body weight [ 43 ]. When restraint-stressed rats, were evaluated in elevated plus maze test, tail suspension test, and forced swimming test after treatment with ethanol extract of Ocimum tenuiflorum leaves, 200 mg/kg body weight dose had better antistress effects [ 44 ]. Aqueous extract of Ocimum tenuiflorum leaves at a dose of 100 mg/kg body weight has shown antistress effects in rats subjected to restraint stress [ 14 , 45 ].…”