Evaluation of store lesion in platelet obtained by apheresis compared to platelet derived from whole blood and its impact on the in vitro functionality

Quintero, Maribel; Nunez, Maria; Mellado, S.; Maldonado, Mónica; Wehinger, Sergio

doi:10.1016/j.transci.2015.05.020

Cited by 6 publications

(3 citation statements)

References 51 publications

(52 reference statements)

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“…Several processing and storage conditions of PLT concentrates (PCs), such as PLTs obtained by apheresis or from buffy‐coat PCs (BCPCs) and the use of various additive solutions, may influence the quality of PCs …”

mentioning

confidence: 99%

Influence of platelet preparation techniques on in vitro storage quality after psoralen‐based photochemical treatment using new processing sets for triple‐dose units

Lotens¹,

Valensart²,

Najdovski³

et al. 2018

Transfusion

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BACKGROUND: The INTERCEPT Blood System (IBS)for platelets (PLTs) uses a combination of psoralen and ultraviolet-A light to inactivate pathogens that may contaminate PLT concentrates (PCs). However, no data are available on the quality of IBS-treated PLTs from different apheresis and buffy-coat PC preparation platforms using the new triple storage (TS) set. STUDY DESIGN AND METHODS:The objective of this study was to evaluate the TS set on three different preparation platforms compared with the large-volume (LV) set, as control. PLT in vitro metabolic and activation parameters were studied over 7 days.RESULTS: Several statistical differences are observed between the two sets, particularly for pH, oxygen pressure (pO 2 ), carbonic gaz pressure (pCO 2 ), and bicarbonate. The three different preparation techniques influence PLT parameters, and the difference is statistically significant for all the studied parameters, except for pCO 2 . The TS set has the advantage of shorter compound adsorption device time, higher PLT recoveries, and less PLT activation. ABBREVIATIONS: APC = apheresis platelet concentrate; ATP = adenosine triphosphate; BC = buffy-coat; BCPC = buffy-coat platelet concentrate; CAD = compound adsorption device; ELISA = enzymelinked immunosorbent assay; HCO 3 = bicarbonate; IBS = INTERCEPT Blood System; LDH = lactate dehydrogenase; LV = large volume; PAS = platelet additive solution; PC(s) = platelet concentrate(s); PI = pathogen inactivation; PLT = platelet; TACSI PL = Terumo automated centrifuge and separator integration platelet; TS = triple storage; UV = ultraviolet.From the

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mentioning

confidence: 99%

Influence of platelet preparation techniques on in vitro storage quality after psoralen‐based photochemical treatment using new processing sets for triple‐dose units

Lotens¹,

Valensart²,

Najdovski³

et al. 2018

Transfusion

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“…Preparation of PCs, either by apheresis or from whole blood, leads to platelet activation. This activation persists during storage and results in platelet storage lesion . Black et al showed increased markers for platelet storage lesion at Day 5 of storage.…”

Section: Discussionmentioning

confidence: 99%

Analyses of sphingosine‐1‐phosphate in the context of transfusion: how much is in stored blood products and in patient blood?

et al. 2019

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BACKGROUND: Sphingosine-1-phosphate (S1P) is a bloodborne lipid that regulates vascular tone and endothelial permeability. S1P concentrations are reduced in critically ill patients. As hematopoietic cells produce S1P, this study intends to investigate S1P concentrations in blood products during storage and in patient plasma after blood transfusion. STUDY DESIGN AND METHODS: S1Pconcentrations were measured in 83 red blood cell (RBC) units and 73 platelet concentrates (PCs) before and after storage. In addition, 26 critically ill patients who received one or two RBC units were recruited to measure S1P plasma levels before and three times within 24 hours after transfusion.ABBREVIATIONS: ICUs = intensive care units; PCs = platelet concentrates; QCs = quality controls; S1P = sphingosine-1-phosphate.From the

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“…Several processing and storage conditions of PCs, such as PLTs obtained by apheresis or from whole blood and the use of different additive solutions (ASs), were found to be important for PSL . Established variables to detect PSL of PCs include monitoring of cell counts (e.g., PLTs, residual white blood cells [WBCs]), pH values, hypotonic shock response, or P‐selectin (CD62P) surface exposure on PLTs by flow cytometry (FCM) as a surrogate marker for their activation and alpha degranulation .…”

mentioning

confidence: 99%

Analysis of platelet‐derived extracellular vesicles in plateletpheresis concentrates: a multicenter study

et al. 2017

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Evaluation of store lesion in platelet obtained by apheresis compared to platelet derived from whole blood and its impact on the in vitro functionality

Cited by 6 publications

References 51 publications

Influence of platelet preparation techniques on in vitro storage quality after psoralen‐based photochemical treatment using new processing sets for triple‐dose units

Influence of platelet preparation techniques on in vitro storage quality after psoralen‐based photochemical treatment using new processing sets for triple‐dose units

Analyses of sphingosine‐1‐phosphate in the context of transfusion: how much is in stored blood products and in patient blood?

Analysis of platelet‐derived extracellular vesicles in plateletpheresis concentrates: a multicenter study

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