Evaluation of standard liver volume formulae for Chinese adults

Shi, Zhonghua; Yan, Lü-Nan; Li, Bo; Wen, Tianfu

doi:10.3748/wjg.15.4062

Cited by 24 publications

(14 citation statements)

References 158 publications

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“…All of the data were collected from the Chinese Liver Transplant Registry: http://www.cltr.org. The inclusion and exclusion criteria used here have been previously described [21]. We informed the donors and their families of the possible risks of donor hepatectomy.…”

Section: Methodsmentioning

confidence: 99%

Donor Safety in Living Donor Liver Transplantation: A Single-Center Analysis of 300 Cases

2013

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AimTo evaluate the safety to donors of living-donor liver transplantation.MethodsThis study included 300 consecutive living liver tissue donors who underwent operations at our center from July 2002 to December 2012. We evaluated the safety of donors with regard to three aspects complications were recorded prospectively and stratified by grade according to Clavien’s classification, and the data were compared in two stages (the first 5 years’ experience (pre-January 2008) and the latter 5 years’ experience (post-January 2008); laboratory tests such as liver function and blood biochemistry were performed; and the health-related quality of life was evaluated.ResultsThere was no donor mortality at our center, and the overall morbidity rate was 25.3%. Most of the complications of living donors were either grade I or II. There were significantly fewer complications in the latter period of our study than in the initial period (19.9% vs 32.6%, P<0.001), and biliary complications were the most common complications, with an incidence of 9%. All of the liver dysfunction was temporary; however, the post-operative suppression of platelet count lasted for years. Although within the normal range, eight years after operation, 22 donors showed lower platelet levels (189×109/L) compared with the pre-operative levels (267×109/L) (P<0.05). A total of 98.4% of donors had returned to their previous levels of social activity and work, and 99.2% of donors would donate again if it was required and feasible. With the exception of two donors who experienced grade III complications (whose recipients died) and a few cases of abdominal discomfort, fatigue, chronic pain and scar itching, none of the living donors were affected by physical problems.ConclusionWith careful donor selection and specialized patient care, low morbidity rates and satisfactory long-term recovery can be achieved after hepatectomy for living-donor liver transplantation.

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Section: Methodsmentioning

confidence: 99%

Donor Safety in Living Donor Liver Transplantation: A Single-Center Analysis of 300 Cases

2013

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“…The physiological parameters for the average Chinese and average Caucasian were derived from the literature (Brown et al 1997;NHFPC 2007NHFPC , 2014 and are presented in Table S2 in the supplementary materials 2. Several reports from the literature indicate that Chinese have significantly smaller livers than Caucasians (Chan et al 2006;Shi et al 2009;Yuan et al 2008). The physiological parameters provided by the National Health Commission of the People's Republic of China (NHFPC) also show that the Chinese liver volume is 1.3-fold lower than the Caucasian liver volume.…”

Section: Development Of a Pbk Model For Lasiocarpine And Riddelliine mentioning

confidence: 99%

Use of an in vitro–in silico testing strategy to predict inter-species and inter-ethnic human differences in liver toxicity of the pyrrolizidine alkaloids lasiocarpine and riddelliine

et al. 2019

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Lasiocarpine and riddelliine are pyrrolizidine alkaloids (PAs) known to cause liver toxicity. The aim of this study was to predict the inter-species and inter-ethnic human differences in acute liver toxicity of lasiocarpine and riddelliine using physiologically based kinetic (PBK) modelling based reverse dosimetry of in vitro toxicity data. The concentration-response curves of in vitro cytotoxicity of lasiocarpine and riddelliine defined in pooled human hepatocytes were translated to in vivo dose-response curves by PBK models developed using kinetic data obtained from incubations with pooled tissue fractions from Chinese and Caucasian individuals, providing PBK models for the average Chinese and average Caucasian, respectively. From the predicted in vivo dose-response curves, the benchmark dose lower and upper confidence limits for 5% effect (BMDL 5 and BMDU 5) were derived and subsequently compared to those previously obtained in rat to evaluate inter-species differences. The inter-species differences amounted to 2.0-fold for lasiocarpine and 8.2-fold for riddelliine with humans being more sensitive than rats. The inter-ethnic human differences varied 2.0-fold for lasiocarpine and 5.0-fold for riddelliine with the average Caucasian being more sensitive than the average Chinese. In conclusion, the present study provides the proof-of-principle to predict inter-species and inter-ethnic differences in in vivo liver toxicity for PAs by an alternative testing strategy integrating in vitro cytotoxicity data with PBK modelling-based reverse dosimetry.

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“…The donor selection process includes health screening, blood tests, virological examination, imaging examination and psychological assessment. The inclusion and exclusion criteria were reported previously [ 3 ].…”

Section: Methodsmentioning

confidence: 99%

Donor Safety in Adult-Adult Living Donor Liver Transplantation: A Single-Center Experience of 356 Cases

2016

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BackgroundAs an important means to tackle the worldwide shortage of liver grafts, adult-adult living donor liver transplantation (A-ALDLT) is the most massive operation a healthy person could undergo, so donor safety is of prime importance. However, most previous research focused on recipients, while complications in donors have not been fully described or investigated.Material/MethodsTo investigate donor safety in terms of postoperative complications, the clinical data of 356 A-ALDLT donors in our center from January 2002 to September 2015 were retrospectively analyzed. These patients were divided into a pre-2008 group (before January 2008) and a post-2008 group (after January 2008). Donor safety was evaluated with regard to the type, frequency, and severity of postoperative complications.ResultsThere were no donor deaths in our center during this period. The overall complication rate was 23.0% (82/356). The proportion of Clavien I, II, III, and IV complications was 51.2% (42/82), 25.6% (21/82), 22.0% (18/82), and 1.2% (1/82), respectively. In all the donors, the incidence of Clavien I, II, III, and IV complications was 11.8% (42/356), 5.9% (21/356), 5.1% (18/356), and 0.3% (1/356), respectively. The overall complication rate in the post-2008 group was significantly lower than that in the pre-2008 group (18.1% (41/227) vs. 32.6% (42/129), P<0.01). Biliary complications were the most common, with an incidence of 8.4% (30/356).ConclusionsThe risk to A-ALDLT donors is controllable and acceptable with improvement in preoperative assessment and liver surgery.

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Evaluation of standard liver volume formulae for Chinese adults

Cited by 24 publications

References 158 publications

Donor Safety in Living Donor Liver Transplantation: A Single-Center Analysis of 300 Cases

Donor Safety in Living Donor Liver Transplantation: A Single-Center Analysis of 300 Cases

Use of an in vitro–in silico testing strategy to predict inter-species and inter-ethnic human differences in liver toxicity of the pyrrolizidine alkaloids lasiocarpine and riddelliine

Donor Safety in Adult-Adult Living Donor Liver Transplantation: A Single-Center Experience of 356 Cases

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