Evaluation of Spray-Drying as a Method to Prepare Microparticles for Controlled Drug Release

Spray-drying Nanocapsules in Presence of Colloidal Silica as Drying Auxiliary Agent: Formulation and Process Variables Optimization Using Experimental Designs

“…Colloidal silica is well known as a technical agent in spray-drying for increasing the particles densities (32,33). It should be noted that increasing the silica fraction led to a moderate increase in the density.…”

Nanoparticle-coated organic-inorganic microparticles: experimental design and gastrointestinal tolerance evaluation

“…Microparticles can be prepared by several physical and chemical methods including solvent evaporation, spray-drying and in situ polymerization 1 . The spray-drying technique has been successfully employed in the preparation of microparticulate delivery systems [6][7][8][9][10][11] . This method exhibits advantages such as a rapid and one-step process, it is applicable to heat-sensitive materials and presents an easy industrial transposition 12 .…”

Microencapsulation of budesonide with dextran by spray drying technique for colon-targeted delivery: anin vitro/in vivoevaluation in induced colitis in rat

“…After preparing chemical conjugates of budesonide with dextran using succinate (Varshosaz et al, 2009) and glutarate (Varshosaz et al, 2010a) spacers and studying their effectiveness in acetic acid induced colitis in rats (Varshosaz et al, 2010b), we tried to see if physical methods like microencapsulation of budesonide in dextran is also suitable for colon specific delivery of this drug or not. Different microspheres for sustained release formulations have been prepared by spray drying method (Palmieri et al, 1994;Billon et al, 2000;Moretti et al, 2001). Spray drying of drug with polysaccharidic polymers which are degraded by colonic microflora is a simple one-step method for preparing microparticles for colon-specific drug delivery.…”