Evaluation of Sperm Selection Technique Using Hyaluronic Acid Binding During Icsi; a Randomized Controlled Trial

Abstract

In-vitro sperm selection for intracytoplasmic sperm injection (Physiological ICSI or PICSI) is crucial as it has a direct influence on the paternal contribution of preimplantation embryogenesis. Men with oligozoospermia who require ICSI often demonstrate compromised DNA integrity and increased chromosomal aberrations of the sperms in their semen. Studies have shown that embryos resulting from ICSI in those men have higher risk of sex chromosome disomies, chromosomal aneuploidies, de novo numerical chromosomal aberrations and cytogenetically detectable structural chromosomal aberrations. Although the primary candidates for ICSI are oligozoospermic men, there is an increase in the use of ICSI; therefore, more couples are potentially exposed to those potential risks.