Evaluation of Spatially Fractionated Radiotherapy (GRID) and Definitive Chemoradiotherapy With Curative Intent for Locally Advanced Squamous Cell Carcinoma of the Head and Neck: Initial Response Rates and Toxicity

Peñagarícano, José; Moros, Eduardo G.; Ratanatharathorn, Vaneerat; Yan, Yulong; Corry, Peter M.

doi:10.1016/j.ijrobp.2009.03.030

Cited by 85 publications

(122 citation statements)

References 29 publications

Supporting

Mentioning

112

Contrasting

Unclassified

Order By: Relevance

“…Their grids had 1 cm hole diameters with center‐to‐center spacing of 1.8 cm. However, in the clinical report by Peñagarícano et al (20) which was based on MLC system for grid therapy, the hole spacing was 1 cm. All the clinical reports of grid therapy referred to curative or palliative advanced tumors (mostly stage III/IV) with sizes larger than 6 cm.…”

Section: Methodsmentioning

confidence: 97%

“…The clinical responses of the patients from different publications, which were treated with grid therapy, have been used to validate the results of the model introduced in this investigation 7 , 9 , 10 , 18 , 19 , 20 . Since the correlation of the responses of the grid therapy with the radiation sensitivity of tumors that were needed from each publication, we focused on the total responses of the treatments, based on the tumor histology and treatment site.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Is grid therapy useful for all tumors and every grid block design?

Gholami

Nedaie

Longo

et al. 2016

J Applied Clin Med Phys

View full text Add to dashboard Cite

Grid therapy is a treatment technique that has been introduced for patients with advanced bulky tumors. The purpose of this study is to investigate the effect of the radiation sensitivity of the tumors and the design of the grid blocks on the clinical response of grid therapy. The Monte Carlo simulation technique is used to determine the dose distribution through a grid block that was used for a Varian 2100C linear accelerator. From the simulated dose profiles, the therapeutic ratio (TR) and the equivalent uniform dose (EUD) for different types of tumors with respect to their radiation sensitivities were calculated. These calculations were performed using the linear quadratic (LQ) and the Hug‐Kellerer (H‐K) models. The results of these calculations have been validated by comparison with the clinical responses of 232 patients from different publications, who were treated with grid therapy. These published results for different tumor types were used to examine the correlation between tumor radiosensitivity and the clinical response of grid therapy. Moreover, the influence of grid design on their clinical responses was investigated by using Monte Carlo simulations of grid blocks with different hole diameters and different center‐to‐center spacing. The results of the theoretical models and clinical data indicated higher clinical responses for the grid therapy on the patients with more radioresistant tumors. The differences between TR values for radioresistant cells and radiosensitive cells at 20 Gy and 10 Gy doses were up to 50% and 30%, respectively. Interestingly, the differences between the TR values with LQ model and H‐K model were less than 4%. Moreover, the results from the Monte Carlo studies showed that grid blocks with a hole diameters of 1.0 cm and 1.25 cm may lead to about 19% higher TR relative to the grids with hole diameters smaller than 1.0 cm or larger than 1.25 cm (with 95% confidence interval). In summary, the results of this study indicate that grid therapy is more effective for tumors with radioresistant characteristics than radiosensitive tumors.PACS number(s): 87.55.‐x

show abstract

Section: Methodsmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

Is grid therapy useful for all tumors and every grid block design?

Gholami

Nedaie

Longo

et al. 2016

J Applied Clin Med Phys

View full text Add to dashboard Cite

show abstract

“…An additional approach which has the potential to offer further improvement is spatially fractionated radiation therapy (GRID). GRID describes the delivery of a single high dose fraction to a large treatment area which has been divided into several smaller fields with steep dose gradients thus reducing the overall toxicity of the treatment [3,4]. In this review, we consider spatially fractionated radiotherapy approaches focusing on GRID and IMRT, and present complementary evidence from different studies which support the role of radiation induced signaling effects in the overall radiobiological rationale for these treatments.…”

Section: Introductionmentioning

confidence: 99%

High dose bystander effects in spatially fractionated radiation therapy

et al. 2015

View full text Add to dashboard Cite

Traditional radiotherapy of bulky tumors has certain limitations. Spatially fractionated radiation therapy (GRID) and intensity modulated radiotherapy (IMRT) are examples of advanced modulated beam therapies that help in significant reductions in normal tissue damage. GRID refers to the delivery of a single high dose of radiation to a large treatment area that is divided into several smaller fields, while IMRT allows improved dose conformity to the tumor target compared to conventional three-dimensional conformal radiotherapy. In this review, we consider spatially fractionated radiotherapy approaches focusing on GRID and IMRT, and present complementary evidence from different studies which support the role of radiation induced signaling effects in the overall radiobiological rationale for these treatments.

show abstract

“…Der ungewöhnliche radiotherapeutische Ansatz Köhlers und Harings fand nachträglich mit der Einführung von Hochvoltgeräten Anerkennung und eine breitere klinische Anwendung in den Fünfziger und Sechziger Jahren [32,[49][50][51]; auch zu Beginn der Telekobalt-Therapie wurden Siebbestrahlungen durchgeführt [51]. Noch heute wird die Methode der räumlichen Fraktionierung klinisch angewandt [52]. Mit zwei Ausnahmen [53,54] wird aber Köhlers Gittertherapie in den uns bekannten Abhandlungen über die Geschichte der Rönt-genologie nicht erwähnt [1,24,[55][56][57][58][59] ,,La radiothérapie est à la fois le fruit le plus inattendu et le plus précieux de la découverte de Roentgen."…”

Section: Erprobung Der Gittertherapieunclassified