Evaluation of Spatial Working Memory Function in Children and Adults with Fetal Alcohol Spectrum Disorders: A Functional Magnetic Resonance Imaging Study

Malisza, Krisztina L.; Allman, Ava-Ann; Shiloff, Deborah; Jakobson, Lorna S.; Longstaffe, Sally; Chudley, Albert E.

doi:10.1203/01.pdr.0000185479.92484.a1

Cited by 97 publications

(95 citation statements)

References 28 publications

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“…The first fMRI study that examined functional abnormalities in PAE subjects has just been published recently (Malisza et al 2005). The lack of published research probably reflects the difficulties of applying functional imaging approaches in the investigation of this disorder, which on the other hand has been clinically diagnosed for more than 30 years.…”

Section: Discussionmentioning

confidence: 99%

Occipital-temporal Reduction and Sustained Visual Attention Deficit in Prenatal Alcohol Exposed Adults

Peltier

et al. 2007

Brain Imaging and Behavior

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Visual attention problems have been reported in association with prenatal alcohol exposure (PAE). With related behavioral data documented in literature, further investigation of this PAE effect would benefit from integrating functional and anatomical imaging data to ascertain its neurobiological basis. The current study investigated the possible functional and anatomical bases for the PAE-related visual sustained attention deficit. Functional magnetic resonance imaging (fMRI) data were collected while the subjects performed a sustained visual attention task. High resolution, three dimensional anatomical images were also collected for morphometric evaluation. In the alcohol-affected subjects, we observed a significant white and gray matter volume reduction in the occipital-temporal area. Meanwhile, their fMRI activations in the same region resided more superiorly than that of the controls resulting in reduced activation in the ventral occipital-temporal area. The location of this PAE functional abnormality approximately matches that of the significant structural reduction. In addition to the well documented corpus callosum abnormalities observed in PAE subjects, the present results reveal a teratogenic effect on the occipital-temporal area. Furthermore, as the occipital-temporal area plays an important role in visual attention, the current observation suggests a neurobiological underpinning for the PAE related deficit in sustained visual attention.

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Section: Discussionmentioning

confidence: 99%

Occipital-temporal Reduction and Sustained Visual Attention Deficit in Prenatal Alcohol Exposed Adults

Peltier

et al. 2007

Brain Imaging and Behavior

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“…considerably lower activation levels in the regions of greatest activity in a typically developing child, including the right inferior frontal gyrus, right posterior parietal lobe, right dorsolateral prefrontal cortex and right middle frontal gyrus [105], the superior frontal and parietal lobes [106], the temporal lobe [107], and the basal ganglia [108].…”

Section: Altered Brain Network Recruitment and Activation In Task Permentioning

confidence: 98%

Radiological studies of fetal alcohol spectrum disorders in humans and animal models: An updated comprehensive review

Nguyen

Chong

Tieng

et al. 2017

Magnetic Resonance Imaging

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“…Although functional neuroimaging studies using positron emission tomography (PET) have demonstrated clear hippocampal activations during virtual tests of spatial navigation in typically developing children (Ghaem et al, 1997;Maguire et al, 1998), this has yet to be investigated in children with FASDs. In fact, apart from the study by Sowell et al (2007) and one examining spatial working memory in children with FASDs (Malisza et al, 2005), no study to our knowledge has yet examined the relation between learning and memory impairments and abnormalities in brain activation in children with FASDs.…”

Section: Introductionmentioning

confidence: 99%

Effects of prenatal alcohol exposure on hippocampal volume, verbal learning, and verbal and spatial recall in late childhood

Willoughby

Sheard

Nash

et al. 2008

J Int Neuropsychol Soc

158

164

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Children with prenatal alcohol exposure (PAE) show deficits in verbal learning and spatial memory, as well as abnormal hippocampal development. The relationship between their memory and neuroanatomic impairments, however, has not been directly explored. Given that the hippocampus is integral for the synthesis and retrieval of learned information and is particularly vulnerable to the teratogenic effects of alcohol, we assessed whether reduced learning and recall abilities in children with fetal alcohol spectrum disorders (FASDs) are associated with abnormal hippocampal volumes. Nineteen children with FASDs and 18 typically developing controls aged 9 to 15 years were assessed for verbal learning and verbal and spatial recall and underwent structural magnetic resonance imaging. Images were analyzed for total intracranial volume and for right and left hippocampal volumes. Results revealed smaller left hippocampi and poorer verbal learning and verbal and spatial recall performance in children with FASDs than controls, as well as positive correlations between selective memory indices and hippocampal volumes only in the FASD group. Additionally, hippocampal volumes increased significantly with age in controls only, suggesting that PAE may be associated with long-term abnormalities in hippocampal development that may contribute to impaired verbal learning and verbal and spatial recall. (JINS, 2008(JINS, , 14, 1022(JINS, -1033

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Evaluation of Spatial Working Memory Function in Children and Adults with Fetal Alcohol Spectrum Disorders: A Functional Magnetic Resonance Imaging Study

Cited by 97 publications

References 28 publications

Occipital-temporal Reduction and Sustained Visual Attention Deficit in Prenatal Alcohol Exposed Adults

Occipital-temporal Reduction and Sustained Visual Attention Deficit in Prenatal Alcohol Exposed Adults

Radiological studies of fetal alcohol spectrum disorders in humans and animal models: An updated comprehensive review

Effects of prenatal alcohol exposure on hippocampal volume, verbal learning, and verbal and spatial recall in late childhood

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