Evaluation of Sound Speed for Detection of Liver Fibrosis

Boozari, B.; Potthoff, Andrej; Mederacke, Ingmar; Hahn, Andreas; Reising, Ansgar; Rifai, K.; Wedemeyer, Heiner; Bahr, Matthias J.; Kubicka, Stefan; Manns, Michael P.; Gebel, M.

doi:10.7863/jum.2010.29.11.1581

Cited by 33 publications

(15 citation statements)

References 27 publications

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“…Boozari et al11 reported the usefulness of evaluation of sound speed for detection of liver fibrosis. Transient elastography by Fibroscan (Echosens, Paris, France) has been accepted as a noninvasive method for assessment of liver fibrosis.…”

Section: Discussionmentioning

confidence: 99%

“…Now our system is being upgraded to be able to calculate the specific point as Boozari et al11 did. For example, pancreatic cancer, neuroendocrine tumor, chronic pancreatitis have their own hardness, our system may give the differential diagnosis from the entirely different point of view if the upgrade mentioned above comes to realization.…”

Section: Discussionmentioning

confidence: 99%

“…However, different types of tissue have different sound properties11-14 and even the same type of tissue may not have similar properties from patient to patient. Therefore, these built-in assumptions are often inaccurate.…”

Section: Methodsmentioning

confidence: 99%

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Feasibility of Newly Developed Endoscopic Ultrasound with Zone Sonography Technology for Diagnosis of Pancreatic Diseases

et al. 2013

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Background/AimsTo confirm the feasibility of using newly developed endoscopic ultrasound (EUS) with Zone sonography™ technology (ZST; Fujifilm Corp.).MethodsSeventy-five patients with pancreatic disorders were enrolled: 45 with intraductal papillary mucinous neoplasm; 15 with ductal carcinoma; five with neuroendocrine tumors; three with serous cystic neoplasms; and seven with simple cysts. The endoscopes used were EG-530UR2 and EG-530UT2 (Fujifilm Corp.). Two items were evaluated: visualization depth among four frequencies and image quality after automatic adjustment of sound speed (AASS), assessed using a 5-scale Likert scale by two endosonographers blinded to disease status. Because sound speed could be manually controlled, besides AASS, image quality at sound speeds of 1,440 and 1,600 m/sec were also assessed.ResultsIn all cases, sufficient images were obtained in the range of 3 cm from the EUS probe. Judgments of image quality before AASS were 3.49±0.50, 3.65±0.48, respectively. After AASS, A and B scored 4.36±0.48 and 4.40±0.49 (p<0.0001). There were significant differences in the data before and after AASS and plus 60 m/sec, but no significant difference between the datasets were seen after AASS and at sound speeds manually set for minus 100 m/sec.ConclusionsEUS with ZST was shown to be feasible in this preliminary experiment. Further evaluation of this novel technology is necessary and awaited.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Feasibility of Newly Developed Endoscopic Ultrasound with Zone Sonography Technology for Diagnosis of Pancreatic Diseases

et al. 2013

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“…The literature reports that mechanical elastography has been used as an auxiliary method in conventional ultrasound imaging for differentiating malignant from benign focal lesions (O'Brian and Holmes, 2007). Preliminary studies of its use in liver tissue have aimed to standardize the technique and evaluate its diagnostic value in detecting focal and diffuse lesions, differentiating malignant and benign processes (Carvalho et al, 2012), and detecting degenerative and inflammatory processes (Orlacchio et al, 2012) in addition to quantifying fibrosis in human (Boozari et al, 2010) and canine (Rivero-Juárez et al, 2012) patients. For these reasons, many expectations have been generated regarding this new technique (Jaffer et al, 2012).…”

Section: Primary Applications Of Elastographymentioning

confidence: 99%

Elastography: Principles and considerations for clinical research in veterinary medicine cibele

Figueira¹,

Thassila²,

Maria³

2015

J. Vet. Med. Anim. Health

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Since the beginning of medicine, palpation has been the primary semiologic method used to detect abnormalities during clinical examination. The mechanical properties of soft tissues are usually related to changes in stiffness. However, changes in stiffness and echogenicity of soft tissues are not always correlated. Elastography has emerged in the last decade as a new method that, when used in association with ultrasonography, can provide information about the acoustic properties (echogenicity and texture) and mechanical attributes (stiffness) of a region of interest in a specific tissue. The objective of this article is to review the literature on the physical principles of elastography and to describe several features of the elastographic imaging process to provide a better understanding of this new technique and its potential utilization in the veterinary field.

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“…Liver fibrosis represents the pathologic basis of many chronic liver diseases; therefore, it is very important to provide an accurate assessment of the liver fibrosis degree for the diagnosis of disease, and in patients with chronic viral hepatitis, to select appropriate antiviral therapy and predict the prognosis [1, 2]. The “gold standard” method for quantifying fibrosis is still percutaneous liver biopsy, although it is an invasive technique and it has some disadvantages such as post-procedural abdominal pain and the risk of serious complication [3].…”

Section: Introductionmentioning

confidence: 99%

Real-Time Elastography: Noninvasive Diagnostic Tool in the Evaluation of Liver Stiffness in Patients with Chronic Viral Hepatitis, Correlation with Histological Examination

Ippolito

Schiavone

Franzesi

et al. 2018

Dig Dis

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Purpose: To determine the value of real-time elastography (RTE) in the assessment of liver stiffness in patients with chronic viral hepatitis, correlating RTE data with the extent of fibrosis based on biopsy findings (Ishak score). Methods: We evaluated 98 patients (45–75 years) with chronic viral hepatitis (51 HCV, 47 HBV) by using ultrasonography (US) study combined with RTE analysis. In the RTE images, relative tissue stiffness is expressed, according to color scale, with soft areas represented in green/red colors and hard areas in blue. We divided the patients into 2 groups based on the fibrosis degree: soft degree (D1, corresponding to F1–F3 Ishak score) and hard degree (D2, corresponding to F4–F6). Before RTE, all patients underwent a US-guided percutaneous liver biopsy (right lobe). Results: Quantitative RTE data were compared with liver biopsy by using the Spearman correlation coefficient in order to assess the correlation between the RTE (D) and fibrosis, according to Ishak score (F) at histology. At RTE, out of 98 patients 55 had degree D1 and 43 had degree D2; at histological analysis, we observed the following: 15 patients with F1, 28 with F2, 17 with F3, 16 with F4, 12 with F5, and 10 with F6. The Spearman’s coefficient showed significant correlation between D and F degree, obtaining rho = 0.573, p = 0.003. Conclusions: RTE analysis showed high diagnostic accuracy in the assessment of fibrosis, and it appears to be a useful diagnostic tool for noninvasive quantification of fibrosis in patients with chronic viral hepatitis.

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Evaluation of Sound Speed for Detection of Liver Fibrosis

Abstract: The SV of liver tissue depends on the fibrosis stage. An SV of 1589 m/s or higher detects cirrhosis with high sensitivity. Therefore, SV measurement appears to be a promising new method for noninvasive quantification of liver fibrosis.

Cited by 33 publications

References 27 publications

Feasibility of Newly Developed Endoscopic Ultrasound with Zone Sonography Technology for Diagnosis of Pancreatic Diseases

Feasibility of Newly Developed Endoscopic Ultrasound with Zone Sonography Technology for Diagnosis of Pancreatic Diseases

Elastography: Principles and considerations for clinical research in veterinary medicine cibele

Real-Time Elastography: Noninvasive Diagnostic Tool in the Evaluation of Liver Stiffness in Patients with Chronic Viral Hepatitis, Correlation with Histological Examination

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