Evaluation of some biological activities of the tubers of Corydalis solida (L.) Clairv. ssp. incisa Liéden growing in Turkey

Kılıç, Mehtap; Kaya, Erdal; Aysal, Ayhan Ibrahim; Şener, Bilge

doi:10.1016/j.sajb.2019.08.055

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…LC-QTOF-MS analysis parameters of G coded sub-fractions [Column: TC-C18 170Å (4.6 mm × 150 mm × 5 μm; Column oven: 30 °C; Injection amount: 10 μl; Analysis time: 82 min; Mobile phase A: 0.1% acetic acid (v/v); Mobile phase B: Acetonitrile; Flow: 0.65 ml/ min; Flow program; 0 min-5% B, 4 min-5% B, 12 min-10% B, 15 min-10% B, 28 min-20% B, 48 min-40% B, 60 min-60% B, 65 min-70% B; 66 min-90% B; 72 min-90% B; 72.10 min-5% B; UV: 260 nm (20 Hz); Ionization mode: Negative; Drying gas temperature: 200 °C; Drying gas flow, nitrogen: 14 L/min; Nebulizer: 40 psi; Sheath gas temperature: 375 °C; Sheat gas flow, nitrogen: 11 L/min; Capillary voltage: 1100 V; Nozzle voltage: 2000 V; Mass reading range: 30-1700 amu; Reference ions: 980.0147, 1033.9881. Data evaluation and identification were done using Agilent Masshunter Software and Metlin Metabolite database and m/z values, fragment ions and retention time (if standards are available) (Kılıc et al, 2019).…”

Section: Characterization Of Sub-fractions By Lc-qtof-ms Analysismentioning

confidence: 99%

Investigation of Antidiabetic Effect of Pistacia atlantica Leaves by Activity-Guided Fractionation and Phytochemical Content Analysis by LC-QTOF-MS

Pekacar

Orhan

2022

Front. Pharmacol.

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In this study, the antidiabetic, antiobesity, antioxidant, and antihyperlipidemic effects potential of Pistacia atlantica Desf. leaves were evaluated by in vitro methods. The effects of the leaves of the plant on pancreatic lipase, pancreatic cholesterol esterase, and PTP1B enzymes were investigated for the first time and it was observed that leaf methanol extract (IC50: 123.67 ± 0.40 μg/ml) and n-hexane sub-extract (IC50: 61.03 ± 0.11 μg/ml) had much stronger effects on pancreatic cholesterol esterase enzyme than simvastatin (IC50: 142.30 ± 5.67 μg/ml). The methanolic extract of P. atlantica leaves exerted strong inhibitory effect on the enzymes (α-amylase and α-glucosidase) effective on carbohydrate digestion. It was thought that the methanol extract could provide significant benefits against oxidative stress in diabetes mellitus since it showed antioxidant activities (DPPH radical scavenging activity and reducing power) as strong as reference compounds (ascorbic acid and quercetin). Qualitative and quantitative analyzes of rutin (0.328 ± 0.000 g/100 g dry extract), methyl gallate (5.245 ± 0.014 g/100 g dry extract), quercetin-3-O-glucoside (0.231 ± 0.000 g/100 g dry extract), and gallic acid (0.528 ± 0.127 g/100 g dry extract) in methanol extract were performed by RP-HPLC. The phytochemical content of the active sub-fraction obtained from the leaf methanol extract by activity-guided fractionation and column chromatography studies was characterized by LC-QTOF-MS. The presence of trigalloylglucose, digalloylglucose, and methyl gallate in the G6 coded sub-fraction obtained by chromatographic techniques from the ethyl acetate sub-extract, which has the highest inhibitory effect on α-amylase and α-glucosidase enzymes, was determined by LC-QTOF-MS. In addition to the G5 coded subfraction, a strong α-glucosidase enzyme inhibitory activity was also observed in the G6 coded sub-fraction, and methyl gallate, methyl digallate, 2″-O-galloyl-quercetin-3-O-hexoside, and myricetin-3-O-hexoside were identified in this sub-fraction. This study displayed that the methanol extract of P. atlantica leaves could be a potential source for bioactive compounds with antidiabetic effects by showing inhibitory effects on enzymes involved in carbohydrate digestion.

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Section: Characterization Of Sub-fractions By Lc-qtof-ms Analysismentioning

confidence: 99%

Investigation of Antidiabetic Effect of Pistacia atlantica Leaves by Activity-Guided Fractionation and Phytochemical Content Analysis by LC-QTOF-MS

Pekacar

Orhan

2022

Front. Pharmacol.

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“…In recent studies, it has been reported that some Corydalis species can be used against Alzheimer's disease. It has been proven that isoquinoline alkaloids isolated from various Corydalis species have acetylcholinesterase inhibitory effects [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Comparative morphological and anatomical investigations on Corydalis caucasica subsp. abantensis Lidén and Corydalis integra Barbey & Fors.-Major (Papaveraceae) from Turkey

Olcay¹,

Kültür²

2021

jrp

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In this study morphological and anatomical features of Corydalis caucasica subsp. abantensis and Corydalis integra which spreading naturally in the same area in Turkey were investigated. The morphological features that can be used to distinguish these two taxa from each other are given in a comparative table. Morphological data were obtained by using herbarium samples collected from different localities and their measurements were given comparatively. In anatomical study, cross and superficial sections from the leaves and cross sections from the stem and roots of the samples were taken and examined under the light microscope; thereby the anatomical structures were determined. Determined anatomical structures were measured and the data obtained were written comparatively. As a result, the morphological features of these two taxa were examined and information that would facilitate identification of these taxa was obtained. The anatomical properties of these two taxa, which were not encountered in any study before, have been elucidated for the first time.

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Anti-cholinergic activities of Turkish Corydalis DC. species

Kılıç¹,

Şener

Kaya³

2021

Phytochemistry Letters

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Evaluation of some biological activities of the tubers of Corydalis solida (L.) Clairv. ssp. incisa Liéden growing in Turkey

Cited by 4 publications

References 12 publications

Investigation of Antidiabetic Effect of Pistacia atlantica Leaves by Activity-Guided Fractionation and Phytochemical Content Analysis by LC-QTOF-MS

Investigation of Antidiabetic Effect of Pistacia atlantica Leaves by Activity-Guided Fractionation and Phytochemical Content Analysis by LC-QTOF-MS

Comparative morphological and anatomical investigations on Corydalis caucasica subsp. abantensis Lidén and Corydalis integra Barbey & Fors.-Major (Papaveraceae) from Turkey

Anti-cholinergic activities of Turkish Corydalis DC. species

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