Evaluation of solvents’ effect on solubility, intermolecular interaction energies and habit of ascorbic acid crystals

Hassan, Sadaf ul; Adam, Fatmawati; Bakar, Mohd Rushdi Abu; Mudalip, Siti Kholijah Abdul

doi:10.1016/j.jscs.2018.07.002

Cited by 38 publications

(31 citation statements)

References 31 publications

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“…Ascorbic acid has a higher solubility in pure water than absolute ethanol, thereby more hydrogen bonding establishment form with water molecules. Also, the higher solubility could promote more free electron transfer for fast nucleation of Au 0 monomers that lead to slow growth of GNPs [30]. Due to these facts, the growth rate of GNPs was inversed to the polarity index value of ethanol-water solvent mixture.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Various Size Gold Nanoparticles by Chemical Reduction Method with Different Solvent Polarity

et al. 2020

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Complicated and strict protocols are followed to tune the size of gold nanoparticles (GNPs) in chemical synthesis methods. In this study, we address the polarity of solvents as a tool for tailoring the size of GNPs in the chemical reduction method. The effects of varying polarity index of the reaction medium on synthesizing gold nanoparticles by chemical reduction method have been investigated. Ethanol as a polar solvent, ethanol-water mixture as reaction medium, L-ascorbic acid as reducing agent, and polyvinylpyrrolidone as stabilizer were used to synthesize GNPs. The polarity index of the reaction medium was adjusted by changing the volume ratio of ethanol to water. UV-Vis, dynamic light scattering (DLS), and transmission electron microscopy (TEM) characterizations reveal that the growth of nanoparticles was gradually increased (~22 to 219 nm hydrodynamic diameter) with decreasing value of polarity index of the reaction medium (~8.2 to 5.2). Furthermore, the high polarity index of the reaction medium produced smaller and spherical nanoparticles, whereas lower polarity index of reaction medium results in bigger size of GNPs with different shapes. These results imply that the mechanistic of the growth, assembly, and aggregation phenomena of ligand or stabilizer-capped GNPs strongly rely on the polarity of solvent molecules. Using the proposed methodology, wide size range of GNPs with different morphology sizes can be synthesized by simply modulating the volume percentage of organic solvent in the reaction medium.

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Section: Resultsmentioning

confidence: 99%

Synthesis of Various Size Gold Nanoparticles by Chemical Reduction Method with Different Solvent Polarity

et al. 2020

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“…Solvents of increasing polarity: DMSO < EtOH < MeOH were investigated for their drug-loading efficiency into PVA filaments. Model drugs FS and 5-ASA are both polar; dissolving in solvents of higher polarity allows for generation of a larger concentration gradient for drug diffusion into the polymer (PVA) filament, therefore giving higher drug-loading in the presence of solvents of a higher polarity [32,33].…”

Section: Solvent Choice Optimizationmentioning

confidence: 99%

3D-Printed Solid Dispersion Drug Products

2019

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With the well-known advantages of additive manufacturing methods such as three-dimensional (3D) printing in drug delivery, it is disappointing that only one product has been successful in achieving regulatory approval in the past few years. Further research and development is required in this area to introduce more 3D printed products into the market. Our study investigates the potential of fixed dose combination solid dispersion drug products generated via 3D printing. Two model drugs—fluorescein sodium (FS) and 5-aminosalicyclic acid (5-ASA)—were impregnated onto a polyvinyl alcohol (PVA) filament, and the influence of solvent choice in optimal drug loading as well as other influences such as the physicochemical and mechanical properties of the resultant filaments were investigated prior to development of the resultant drug products. Key outcomes of this work included the improvement of filament drug loading by one- to threefold due to solvent choice on the basis of its polarity and the generation of a 3D-printed product confirmed to be a solid dispersion fixed dose combination with the two model drugs exhibiting favourable in vitro dissolution characteristics.

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“…In a biochemical reaction, the high temperature can decrease the solubility of the compound. According to Hassan et al (2019) mention that, solubility values can be decreased with the decreasing of solvent polarity and increase of van der waals interaction [13]. The different polarity of the solvent interacts with the different thermal condition will give a different mixture of bioactive compound extract.…”

Section: B Response Surface Analysis Of Bcbmentioning

confidence: 99%

Central Composite Design as a Tools for Optimization of Antioxidant Activity on Cocoa Shell Extract

Yusof¹,

Gani²,

Zaidan³

et al. 2019

IJEAT

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This study seeks to analyze and optimize the antioxidant activity thru beta carotene bleaching assay influenced by different extraction condition on extracts obtained from Malaysia Cocoa Shell. The condition was optimized by response surface methodology with five levels of the model. There are three variables involved in this study, namely: ethanol concentration (70-90 v/v %), temperature (45-65 ºC), and ultrasound irradiation time (30-60 min). The optimum condition obtains for temperature, duration of extraction and solvent concentration were 55 ºC, 45 minutes and 63.18% respectively at a constant frequency of 40 kHz. In this condition, the antioxidant activity experimental was 98.91±0.5% and predicted 98.44%. The ANOVA shows the coefficient of determination (R2 ) and the lack of fit test was 0.9846 and 0.6105 respectively. The desirability function from T-test data, modeled equation fits the data, reveals that the design can be used to predicting future observation within the design range.

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Evaluation of solvents’ effect on solubility, intermolecular interaction energies and habit of ascorbic acid crystals

Cited by 38 publications

References 31 publications

Synthesis of Various Size Gold Nanoparticles by Chemical Reduction Method with Different Solvent Polarity

Synthesis of Various Size Gold Nanoparticles by Chemical Reduction Method with Different Solvent Polarity

3D-Printed Solid Dispersion Drug Products

Central Composite Design as a Tools for Optimization of Antioxidant Activity on Cocoa Shell Extract

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